Navigation Links
Drug-Coated Balloons Open Arteries Blocked by Narrowed Stents
Date:11/16/2011

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Nov. 16 (HealthDay News) -- Balloons coated with a drug used to open blocked stents in heart arteries restore blood flow and also reduce bleeding in some high-risk patients, new research shows.

Bare-metal stents, implanted to keep a blood vessel in the heart open during angioplasty, can narrow over time as scar tissue develops, which restricts blood flow and requires another procedure to widen the vessel, the researchers say. They were to present their findings Wednesday at the American Heart Association's annual meeting in Orlando, Fla.

"Drug-eluting [emitting] balloons is, in my opinion, the therapy of choice in case of bare-metal stent restenosis and should be also considered in treating patients with stenosis of native coronary arteries, especially with a high risk of bleeding," said the lead researcher of both studies, Dr. Mariusz Zadura, a senior cardiologist at the Heart and Diabetes Center of Mecklenburg-Vorpommern in Karlsburg, Germany.

"Drug-eluting balloons are as effective in the daily practice in real life conditions in treating bare metal stent restenosis," he added.

In the procedure, a catheter with a drug-coated balloon is passed through the narrowed stent to restore blood flow. The procedure leaves behind the drug, which acts to prevent the stent from renarrowing.

For the first study, Zadura's team studied the responses of 84 patients who had narrowed bare metal stents reopened. The balloons used in the procedure were coated with the drug paclitaxel, a cancer drug also used to prevent blocking of arteries.

In all, 91 stented arteries were treated. After six to nine months, the balloon kept 85 of the arteries open.

New blockages occurred in six stented arteries, but only three patients needed an additional procedure, the researchers noted.

In the second study, the team followed 63 patients who were at high risk of bleeding. These patients were being treated with anti-clotting drugs for other medical problems, such as mechanical heart valves, atrial fibrillation and pulmonary embolism.

These patients also had narrowed stented arteries. Over six to nine months, drug-coated balloons were effective in keeping 69 of 73 narrowed arteries open.

Although narrowing occurred in four stents, only two patients needed another procedure, the researchers reported.

Using the drug-eluting balloon is better than using drug-eluting stents, according to the researchers.

Patients treated with drug-eluting metal stents need daily aspirin and other anti-clotting drugs for at least one year, which can increase the risk of bleeding, the researchers said.

However, they said, patients treated with a drug-coated balloon only need to take dual anti-clotting therapy for one month.

Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, and a spokesman for the American Heart Association, said that "drug-eluting stents significantly attenuate scar formation and the need for repeat procedures; however, dependency on prolonged dual anti-clotting therapy and late-stent thrombosis have led to investigations of alternative treatments."

In recent years, drug-eluting balloons have emerged as an alternative to drug-eluting stents to address blocking of arteries and avoid the need for prolonged dual anti-clotting therapy. Paclitaxel is used to coat the balloons and minimize cell growth, he said.

"Drug-eluting balloon technology has been demonstrated to be safe and potentially efficacious in small studies," Fonarow said.

"Both these patient series showed very good efficacy and safety. These promising findings should be further evaluated in prospective randomized clinical trials," he said.

The studies received no external funding, Zadura said.

Because the research was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

For more information on angioplasty, visit the U.S. National Heart, Lung, and Blood Institute.

SOURCES: Mariusz Zadura, M.D., senior cardiologist, Heart and Diabetes Center of Mecklenburg-Vorpommern, Karlsburg, Germany; Gregg Fonarow, M.D., professor, cardiology, University of California, Los Angeles, and spokesman, American Heart Association; Nov. 16, 2011, presentation, American Heart Association annual meeting, Orlando, Fla.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. St. John Hospital 1st in Michigan to enroll patient in worldwide drug-coated balloon trial
2. Study Supports Selective Use of Drug-Coated Stents
3. Response time to open arteries for most critical patients still too slow
4. Environmental Toxins Linked to Hardening of Arteries
5. Study shows soy protein reduced progression of clogged arteries in women within 5 years of menopause
6. Smoking Harder on Womens Arteries Than Mens, Scans Show
7. Calcified Plaque in Arteries May Be Tied to Stroke, Dementia Risk
8. Ultrasound of Neck Arteries May Help Gauge Stroke Risk
9. Regular Exercise Helps Keep Leg Arteries Clear
10. Predicting perilous plaque in coronary arteries via fluid dynamics
11. Clogged Arteries Might Raise Risk of Dementia, Experts Warn
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug-Coated Balloons Open Arteries Blocked by Narrowed Stents 
(Date:6/27/2017)... ... 27, 2017 , ... A+ Orthodontics is now offering special ... on treating alignment and occlusion irregularities. Treatment often includes the use of braces ... Hollywood dentist , Dr. Garemani, along with Dr. Reza and the rest of ...
(Date:6/26/2017)... ... , ... Antoine Dental Center is now offering various types of dental implants to ... a support for prosthetic teeth, such as crowns, bridges, or dentures. An implant is placed ... lasting new root for the tooth. , Several types of dental implants are available, ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... is revolutionizing the way women look and feel about themselves and their sexual ... female sexual dysfunction and urinary leakage head on with a ground breaking medical ...
(Date:6/26/2017)... WI (PRWEB) , ... June 26, 2017 , ... New ... consultations from Dr. Angela Cotey, with or without a referral. Dr. Cotey is a ... benefits of this preferred tooth replacement option. , Patients with missing teeth in Fitchburg, ...
(Date:6/25/2017)... ... ... An increase in wetter weather in the Northern California area naturally means ... humdinger of an allergy season. A relief from drought conditions is most welcome, but ... weed pollen. , “Our patients have been reporting the typical allergy season symptoms, ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... LAWRENCE, Mass. , June 2, 2017  NxStage ... advancing renal care, today announced new findings demonstrating positive ... NxStage ® System One™. The data will be ... 2017, in Madrid, Spain . ... Knowledge to Improve Home Dialysis Network in ...
(Date:5/29/2017)... May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... which enables the functional selection of stem cells, today ... the first quarter ended March 31 st , 2017. ... accomplishments in the first quarter of 2017," said Dr. ... we announced the treatment of the first blood cancer ...
(Date:5/22/2017)... 22, 2017  Lilac Corp, the company that ... launch of a new website . The ... a clinical study that showed surprising clearance of ... in individuals suffering from HPV warts, precancerous, or ... are no other treatments that clear the virus. ...
Breaking Medicine Technology: