Navigation Links
Drug-Coated Balloons Keep Leg Arteries Open: Study
Date:2/13/2008

Small German trial could be a breakthrough treatment in vascular disease

WEDNESDAY, Feb. 13 (HealthDay News) -- Drug-coated stents haven't worked well for blocked leg arteries, but German doctors are reporting good initial results with drug-coated balloons, which are inserted at the end of catheters and are inflated to reopen the arteries.

Catheters whose balloons were coated with paclitaxel, one of the drugs commonly used for coronary artery stents, were better at keeping leg arteries open than conventional balloon catheters, said the study by researchers at the Eberhard-Karls University in Tuebingen.

Only two of the 48 persons with what is formally known as peripheral artery disease (PAD) who were treated with the coated balloons required second procedures to reopen arteries in the following six months, compared to 20 of the 54 people treated with conventional catheters, the report said.

The difference was evident after two years, when 28 of the 54 people treated with conventional balloons required reopening procedures, compared to seven of the 48 patients treated with coated catheters. Over that period, the drug-treated arteries remained more open than those treated with conventional devices.

No benefit was seen in a third group of patients who were treated with conventional catheters and had paclitaxel dripped into their arteries.

The average age of the study participants was 68; 24 percent were smokers, and 49 percent had diabetes.

The findings are published in the Feb. 14 issue of the New England Journal of Medicine.

"This is a really promising initial look at this technology," said Dr. Daniel Clair, chair of vascular surgery at the Cleveland Clinic. "It is very promising, but we need more data."

Drug-coated stents are not used routinely in the United States for PAD, Clair said. Two trials for PAD done in Europe showed initial advantages of drug-coated stents over the bare-metal kind, he said, but the differences had disappeared after two years, and a number of the stents implanted in leg arteries had fractured, he said.

Several aspects of the German trial raise questions, Clair added. The blockages treated in the study were relatively small, averaging 7.5 centimeters (about 3 inches), Clair noted, while the femoral artery, which is most often affected by PAD, is about 16 inches long.

"I would love to see this kind of trial done in the United States with longer lesions," Clair said.

That thought was echoed by Dr. Issam Moussa, director of endovascular services at New York Presbyterian/Weill Cornell Medical Center in New York City.

"This is obviously very promising, but my initial impression is that this is too good to be true," Moussa said. Drug-coated balloons have been tried for coronary arteries without success, he said, "because not much of the drug goes into the artery wall. My skepticism comes from that biological aspect."

But that view is balanced by "kind of an optimistic perspective," Moussa said. "If this [the German finding] really works, it would be a really big breakthrough. We should design a really big trial with hundreds of patients and more complicated lesions using this device to see if we can replicate the German results."

The German researchers got financial support for their study from a number of drug companies, including stent manufacturers.

More information

For more on PAD, consult the U.S. National Library of Medicine.



SOURCES: Daniel Clair, M.D., chair of vascular surgery, Cleveland Clinic; Issam Moussa, M.D., director of endovascular services, New York Presbyterian/Weill Cornell Medical Center, New York City; Feb. 14, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug-Coated Stents Go Head to Head
2. Study Finds Benefits With Drug-Coated Stents
3. Drug-Coated Stents No Riskier in Long Run Than Bare Metal Ones
4. Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases
5. New Device for Clearing Blocked Arteries in the Legs Receives FDA Clearance for Peripheral Use - Procedures Performed Across the US Within First 48 Hours
6. High-tech CT scans: not a bad choice to test for clogged arteries
7. New Computerized Scans Effective for Spotting Clogged Arteries
8. Super-Thin Drug-Free Coating Hides Stent as It Unblocks Heart Arteries
9. Penn study finds pro-death proteins required to regulate healthy immune function
10. New study shows promise in reducing surgical risks associated with surgical bleeding
11. Study, meta-analysis examine factors associated with death from heatstroke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug-Coated Balloons Keep Leg Arteries Open: Study
(Date:4/24/2017)... , ... April 24, 2017 , ... Michael Vick announced ... transforming the quarterback position. The former overall number one pick in the 2001 NFL ... career. He holds the record for the most career rushing yards by a quarterback ...
(Date:4/24/2017)... ... 2017 , ... As part of the nationwide Days of Remembrance effort led ... Holocaust and Nazi persecution, Center for Medicine after the Holocaust (CMATH) announced ... trip to Germany and Poland next week. , The Fourth Biennial CMATH Champions Trip ...
(Date:4/24/2017)... ... ... Bright Pink , a national non-profit organization focusing on the prevention and early detection of ... is proud to announce Katie Thiede as their new Chief Executive Officer. In January, founder ... of the Board and launched a national search to find a visionary new leader to ...
(Date:4/24/2017)... ... ... Veteran Theresa James awoke to the sound of her newly ex-husband breaking into ... depicts every parent’s worst nightmare, when her three children were violently taken from her. ... my divorce,” James said. “After the death of my children, I continued to journal. ...
(Date:4/24/2017)... ... April 24, 2017 , ... The ... public support to bring their novel lifesaving device for the everyday use of ... medical-grade sensors, specially designed to read a child’s vital signs, and detect unusual ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... Solentim, the developer of instrumentation for ... a major new product line called the VIPS™ ... has been developed for automatically seeding single cells ... of the process to generate clonally-derived cell lines. ... reliable solution when compared to traditional single cell ...
(Date:4/20/2017)... 2017  Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Urology, Uro/Gyn and Gynecology markets with innovative and ... joined the Company as Senior Vice President, Marketing ... Mr. Keswani will report directly to Darin ... organization is delighted that Ash has joined the ...
(Date:4/20/2017)... , April 20, 2017  Zimmer Biomet Holdings, Inc. ... healthcare, today announced that it will be participating in ... at the InterContinental Hotel in Boston, Massachusetts ... will present at 11:20 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
Breaking Medicine Technology: