Navigation Links
Drop of Flu Vaccine Under Tongue Bars Infection
Date:1/28/2008

Mouse study shows promise for human protection in future

MONDAY, Jan. 28 (HealthDay News) -- A drop of vaccine placed under the tongue might one day ward off the flu.

Not only would the new method, so far tested only in mice, be more convenient, it also appears to be more effective than the flu shot or nasal spray, the South Korean researchers noted.

"This has the potential to be widely accepted by people who are afraid of needles, but it's clearly an introductory study and needs to be further studied in humans," said Dr. William Reisacher, an assistant professor of otolaryngology at Weill Cornell Medical College in New York City.

And in developing countries, there is another advantage: indirect prevention of other diseases.

"Sublingual [under the tongue] vaccination elicits broad spectrums of systemic and mucosal immunity. This route is needle-free so that developing countries' people would most benefit to avoid contamination/infection by reused needles," said study senior author Mi-Na Kweon, chief of the Mucosal Immunology Section at the International Vaccine Institute in Seoul.

And according to Kweon, whose study was in this week's issue of the Proceedings of the National Academy of Sciences, "several clinical trials using sublingual route are now ongoing so that it might be not so far away for humans."

Most flu vaccines are delivered via injection, though recently a nasal spray (FluMist) has become available. The flu shot, which contains killed virus, is approved for use in people older than 6 months. The nasal spray is made with live but weakened flu viruses, and is approved for healthy people aged 2 to 49 who are not pregnant.

According to background information in the study, most environmental pathogens, such as the flu virus, enter the body through the respiratory, gastrointestinal and genital tracts.

The sublingual vaccine would provide protection at the point of entry, so to speak. And unlike other oral vaccines, it would avoid subjecting the vaccine to enzymes and acids in the stomach.

Sublingual therapy is already used for allergy drugs in children, primarily in Europe.

In this study, mice were given two doses of either live or inactivated flu virus two weeks apart. Both delivery methods were effective in stimulating the immune system.

When later exposed to a severe form of influenza virus, the animals were fully protected.

Delivering vaccine under the tongue also prevented viruses from traveling to the central nervous system, which is a rare but dangerous complication of the nasal spray.

"They basically showed that the vaccine was able to affect change in the immune system and protected against the flu," Reisacher said. "It's an effective way of exposing a vaccine to the immune system. With sublingual delivery, the vaccine is not absorbed that rapidly but it is maintained in the lining of the mouth -- the mucosa -- allowing the antigen to be exposed [to the immune system]."

More information

For more on current flu vaccines, visit the U.S. Centers for Disease Control and Prevention.



SOURCES: William Reisacher, M.D., assistant professor, otolaryngology, Weill Cornell Medical College, and director, allergy, New York Presbyterian Hospital, New York City; Mi-Na Kweon, Ph.D., chief, Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea; Jan. 28-Feb. 1, 2008, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
3. Vaccine Stops Alzheimers Brain Tangles
4. Human Papilloma Virus vaccines may decrease chances of oral cancer
5. U.S. Teens Fall Short on Vaccine Coverage
6. Nasal Anthrax Vaccine Proves Effective in Animal Study
7. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
8. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
9. Iomai Patch-Based Vaccine Cut Rate of Travelers Diarrhea by 75 Percent in Phase 2 Field Study
10. FDA approves expanded label for FluMist (influenza virus vaccine live, intranasal) to include childr
11. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drop of Flu Vaccine Under Tongue Bars Infection
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... upcoming Feb. 23 webinar, “Intel’s Direct-to-Employee Benefit Model: A Case Study for Plans ... Catholic health care system that’s partnering with Intel on value-based health benefits program ...
(Date:2/11/2016)... Australia (PRWEB) , ... February 11, 2016 , ... ... potential ?" motivational speaker, trainer and author Ray Clarke poses a question as ... personal fulfillment . In his book, "Being in the Being" (published by Partridge ...
(Date:2/11/2016)... City, FL (PRWEB) , ... February 11, 2016 ... ... announced the commencement of a master charity program created to assist the people ... 60 days, working closely with nonprofit organizations and community leaders. Their hope is ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... multi-specialty practice Village Family Practice , will be presenting at the 2016 ... in Las Vegas, Nev. , During his session, “ Coding for Care: ...
(Date:2/11/2016)... ... ... The annual list showcases the 20 Most Promising SharePoint Solution Providers in ... commitment to the SharePoint ecosystem. A panel of experts and members of CIOReview’s editorial ... and promote technology entrepreneurship. , The survey was made at the end of ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 Potrero Medical, Inc., ... pleased to announce the appointment of George M. Rapier, ... San Antonio, TX , WellMed is one of ... 200,000 patients and HMO members in Texas ... in 1990 out of his own internal medicine practice, he ...
(Date:2/11/2016)... , Feb. 11, 2016  NOIT™ Research LLC, a ... "Gift of Change" campaign to assist needy families in ... such unit sold between February 10, 2016 and March ... a needy family. The NOIT is an auditory stimulus ... individuals develop language skills. Beth Shier ...
(Date:2/11/2016)... , Feb. 11, 2016  MiMedx Group, Inc. ... utilizing human amniotic membrane and other birth tissues, human ... to develop and market advanced products and therapies, announced ... Markets, 2016 Global Healthcare Conference in New ... and CEO, Michael J. Senken , Chief Financial ...
Breaking Medicine Technology: