Navigation Links
Drop in breast cancer rates directly tied to reduced hormone therapy
Date:11/30/2010

In a new UCSF study of more than 2 million mammogram screenings performed on nearly 700,000 women in the United States, scientists for the first time show a direct link between reduced hormone therapy and declines in ductal carcinoma in situ (DCIS) as well as invasive breast cancer. The researchers saw such a striking decrease, they believe they also have uncovered indirect evidence that hormones promote breast tumor growth.

The declines occurred in the age groups that most widely embraced then abandoned hormone therapy.

For nearly a decade, postmenopausal women have been strongly advised to refrain from long-term hormone therapy or to use the lowest dose possible for the shortest time to relieve hot flashes and night sweats. Numerous studies have suggested that women taking a combination of progestin and estrogen faced a higher risk of breast cancer and other potential health hazards.

The new findings suggest that hormones helped promote breast tumor growth of preexisting, clinically latent hormone-dependent cancers, not only increasing the incidents of invasive cancer, but also the risk of ductal carcinoma in situ (DCIS).

"We show that the incidence of breast cancer decreases if you take the hormones away,'' said senior author Karla Kerlikowske, MD. "The fact that we're continuing to see a decrease in invasive cancer means that the effects of stopping the hormones may be long-lasting.''

The study has been published online by the "Journal of Clinical Oncology.'' http://jco.ascopubs.org/content/early/2010/11/08/JCO.2010.29.5121.full.pdf+html?sid=b3f9dc48-1229-4ad7-877f-51e633bf1453

The use of hormone therapy surged in the 1980s and '90s an estimated six million American women found that the medications alleviated postmenopausal symptoms. But at the same time, there was a steady increase in the rate of breast cancer.

In mid-2002, following a landmark report of the Women's Health Initiative indicating that the risks of estrogen plus progestin therapy outweighed its benefits, hormone therapy fell into widespread disfavor. Women by the millions gave up hormones cold turkey or incrementally.

In the new UCSF study, scientists reviewed 2,071,814 screening mammography examinations performed between January 1997 and December 2008 on nearly 700,000 women between the ages of 40 and 79 as part of routine regular screening mammography.

They uncovered a clear pattern: women 50 to 69 years old had the highest level of hormone usage and showed the biggest reduction in invasive breast cancer when they stopped, from 40 cancers per 10,000 mammograms in 2002 to 31 cases in 2005, 35 cancers in 2006. Likewise, rates of DCIS markedly dropped in the same age group after hormone therapy ended.

There was a parallel drop in cancer among women older than age 70.

Strikingly, the scientists found that among women 40 to 49 years old, who were less likely to have been on hormone therapy, breast cancer rates did not change over the course of the decade studied.

The results corroborate previous declines in invasive cancer between 2000 and 2003 reported for women aged 50 to 69 by the same group of scientists as well as other researchers. To the authors, the statistics offer convincing evidence that hormone therapy cessation reduces breast cancer risk.

The scientists say major questions remain unanswered: does a halt in hormone therapy correlate to a delay in the clinical detection of tumors, leading to a short-term reduction in cancer rates, but not a long-term drop? Do the effects apply long term for all tumors influenced by hormone therapy?

"The study supports the idea that by giving the hormones we were promoting tumor growths by giving the hormones,'' said Kerlikowske, professor of medicine, and epidemiology and biostatistics at the UCSF Helen Diller Family Comprehensive Cancer Center, and co-director of the Women Veteran's Comprehensive Health Center at SFVAMC. "When the promoter is taken away, the incidence of breast cancer decreases.''

While scientists continue to investigate the relationship between hormones and cancer, Kerlikowske said that using hormone therapy on a short term basis is "probably OK. But long term, it is not OK.''


'/>"/>

Contact: Elizabeth Fernandez
EFernandez@pubaff.ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
2. Women With Breast Cancer History Should Consider MRI: Study
3. Women with personal history of breast cancer should be screened with MRI
4. Women Taking Certain Epilepsy Drugs Can Safely Breast-Feed, Study Suggests
5. Discovery halts breast cancer stem cells
6. Targeted breast ultrasound plays key role in evaluating breast abnormalities in women younger than 40
7. Cough Syrup Might Help With Dosing of Breast Cancer Drug
8. I-SPY 2 study speeds up treatment for breast cancer
9. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
10. Scientists identify potential new target for treating triple negative breast cancer
11. Erythropoietin counteracts breast cancer treatment with herceptin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... Coral Springs, FL (PRWEB) , ... February 13, 2016 , ... ... on the environmental impact of American businesses. , The increasingly modern world of ... rely more often on non-renewable energy sources such as oil and coal, which pollutes ...
(Date:2/13/2016)... Canada (PRWEB) , ... February 13, 2016 , ... In ... foot forward. They’ll groom themselves to perfection, go out of their way to be ... date – just take a look at any online dating profile. , A ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, ... Parishes. The purpose of these scholarships is to encourage applicants to pursue a ... seek employment within these two parishes. , “We have available jobs in St. ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a technology and information ... ISE Southeast Awards 2016. Finalists and winners of the ISE® Awards for both ... and Awards Gala on March 15, 2016 at the Westin Peachtree Plaza, Atlanta. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Maharashtra, February 12, 2016 ... Market research report titled Chronic Inflammation Global Clinical ... a snapshot of the global clinical trials landscape ... clinical trials by Region, Country (G7 & E7), ... point status and reviews top companies involved and ...
(Date:2/11/2016)... PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial results ... The Company also filed its Quarterly Report on Form 10-Q ... Securities and Exchange Commission today. --> ... --> --> Net sales for the ... 95%, to $5.4 million from $2.8 million for the three ...
(Date:2/11/2016)... Feb. 11, 2016  Governor Andrew M. Cuomo today ... 1,400 jobs throughout Western New York ... the SUNY Polytechnic Institute, includes a major expansion of ... Buffalo , as well as the ... in Dunkirk . The combined projects ...
Breaking Medicine Technology: