Navigation Links
Drop in Certain Visual Skills May Precede Alzheimer's
Date:10/12/2009

Decline in spatial understanding can occur 3 years before diagnosis, study finds

MONDAY, Oct. 12 (HealthDay News) -- The ability to perceive relationships between objects (visuospatial skills) may decline years before a person is diagnosed with Alzheimer's disease, a new study suggests.

It included 444 people who were dementia-free when they were enrolled in the study and underwent tests on a number of cognitive abilities, including visuospatial skills. The assessments were repeated at least once before the end of the study. After an average follow-up of 5.9 years, 134 participants had developed dementia. Of those, 44 underwent brain autopsies that confirmed they had Alzheimer's disease.

The researchers used data from the cognitive assessments to chart declines in various areas before participants were diagnosed with dementia. They found an inflection point (sudden change to a steeper slope of decline) in visuospatial abilities three years before clinical diagnosis of dementia.

Declines in overall cognition occurred the next year, while inflection points for verbal and working memory weren't seen until one year before diagnosis.

The findings appear in the October issue of the Archives of Neurology.

"There are several implications of this study," wrote David K. Johnson, of the University of Kansas, and colleagues. "Some of the earliest signs of preclinical disease may occur on tests of visuospatial and speeded psychomotor skills. Furthermore, the greatest rate of preclinical decline may occur on executive and attention tasks. These findings suggest that research into early detection of cognitive disorders using only episodic memory tasks, such as word lists or paragraph recall, may not be sensitive to either all of the earliest manifestations of disease or the most rapidly changing domain."

"In summary, converging longitudinal evidence suggests that after a sharp departure from the relatively flat course of normal aging, there is a preclinical period in Alzheimer's disease with insufficient cognitive decline to warrant clinical diagnosis using conventional criteria but that can be seen with longitudinal data from multiple domains of cognition and not just memory."

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Oct. 12, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Certain Types of Infertility Are Preventable
2. Photodynamic therapy effective for certain head and neck cancers
3. Uncertainty Surrounds Testing for Alzheimers
4. Survey finds just 40 percent of adults absolutely certain they will get H1N1 vaccine
5. Certain cancers more common among HIV patients than non-HIV patients
6. H1N1 Swine Flu Preparedness Uncertainty Results in Higher Business Disruption Risk
7. Trauma 411: Prolonged surgery should be avoided in certain cases
8. Pain Level May Predict Survival in Certain Cancer Patients
9. Bayer Statement on U.S. Food and Drug Administration Advice for Patients: Serious Errors with Certain Blood Glucose Monitoring Test Strips
10. Taking dex can improve high altitude exercise capacity in certain climbers
11. Certain Arthritis, Crohns Drugs May Raise Kids Cancer Risk: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
Breaking Medicine Technology: