Navigation Links
Drinking poses greater risk for advanced liver disease in HIV/hep C patients
Date:5/2/2014

PHILADELPHIAConsumption of alcohol has long been associated with an increased risk of advanced liver fibrosis, but a new study published online in Clinical Infectious Diseases from researchers at Penn Medicine and other institutions shows that association is drastically heightened in people co-infected with both HIV and chronic hepatitis C virus (HCV) infection. Even light ("nonhazardous") drinkingwhich typically poses a relatively low risk for uninfected personswas linked to an increased risk of liver fibrosis in the co-infected group.

Reasons for this are not fully understood, but preclinical studies have shown that the two viruses can induce liver cell death and that adding alcohol may accelerate that process and more quickly lead to severe liver fibrosis. Toxicity to the liver from antiretroviral drugs may also be exacerbated by alcohol.

"We've shown a much greater risk for coinfected compared to uninfected persons at all levels of alcohol consumptionfrom nonhazardous drinking up to hazardous/binge drinking and abuse/dependence," said senior author Vincent Lo Re III, MD, MSCE, assistant professor of Medicine and Epidemiology in the division of Infectious Diseases and department of Biostatistics and Epidemiology at Penn and an infectious disease physician at the Veteran Affairs Medical Center in Philadelphia. "This highlights how important it is for clinicians to be counseling co-infected patients on reducing alcohol consumption. More communication and education about the risks of alcohol may prompt patients to reduce drinking or quit altogether, which will help reduce the incidence of complications."

Few studies have investigated the association between alcohol and liver disease in HIV/HCV-co-infected patients, and none have compared risks to uninfected persons.

For the study, researchers, which included first author Joseph K. Lim, MD, of the Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, conducted a cross-sectional study among 7,270 participants from the Veterans Aging Cohort Study: 701 HIV/HCV co-infected; 1,410 HIV-mono-infected; 296 HCV-mono-infected; and 1,158 uninfected. Alcohol use was determined by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire and diagnoses of alcohol abuse/dependence and classified as nonhazardous drinking, hazardous/binge drinking, and alcohol-related diagnosis.

The team found that regardless of HIV or HCV status, the prevalence of advanced hepatic fibrosis increased as alcohol use category increased. However, the strongest associations were observed in co-infected patients across all alcohol categories compared with uninfected non-hazardous drinkers.

Co-infected individuals with nonhazardous drinking were 13 times more likely to have advanced liver fibrosis than uninfected persons who reported non-hazardous drinking. Co-infected patients with a history of hazardous/binge drinking were 17 times more likely, whereas those who had alcohol-related diagnosis were 21 times more likely, to have advanced liver fibrosis compared to their uninfected non-hazardous drinking counterparts.

"The difference between co-infected and uninfected groups was stark. Given the prevalence of drinking in co-infected individuals, it is important to determine the patterns of alcohol use, such as nonhazardous drinking and even binge drinking, which are not traditionally thought to contribute to liver fibrosis," said Lo Re.


'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Coached extracurricular activities may help prevent pre-adolescent smoking and drinking
2. National survey links teen binge drinking and alcohol brand references in pop music
3. The double whammy of multiple sex partners and drinking in HIV/STI prevention
4. Physical activity and occasional drinking found to be associated with decrease in vision impairment
5. Drinking alcohol several times a week increases the risk of stroke mortality
6. New research reinforces danger of drinking alcohol while pregnant
7. Interventions work to stem freshman drinking
8. Study finds troubling relationship between drinking and PTSD symptoms in college students
9. How To Give Up Alcohol Review
10. How This Program Helps People Control Or Quit Drinking Fast – Vinamy
11. Strong state alcohol policies protective against binge drinking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... June 26, 2017 , ... ... leakage is revolutionizing the way women look and feel about themselves and their ... of female sexual dysfunction and urinary leakage head on with a ground breaking ...
(Date:6/26/2017)... ... June 26, 2017 , ... New patients with missing teeth ... with or without a referral. Dr. Cotey is a trusted dentist who has placed ... replacement option. , Patients with missing teeth in Fitchburg, WI, are encouraged to find ...
(Date:6/25/2017)... (PRWEB) , ... June 25, 2017 , ... An increase ... and growing foliage and plants, and along with that; a humdinger of an allergy ... sufferers, it also means an increase in misery-causing grass and weed pollen. , ...
(Date:6/24/2017)... ... June 24, 2017 , ... ... genetic testing for medications in select Florida and Texas doctors' offices and clinics. ... This new application of genetic testing recognizes the role genes play in determining ...
(Date:6/24/2017)... Killeen, TX (PRWEB) , ... June 24, 2017 , ... ... can boost home security, such as getting a guard dog or having an alarm ... homes simply aren’t secure against forced entry. Yair Frenkel, owner of TX Premier Locksmith ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... LAGUNA HILLS, Calif. , June 20, ... data that validate the use of MMprofiler with SKY92, ... multiple myeloma (MM). In a poster presentation at the ... (EHA) in Madrid, Spain , SkylineDx ... identifying high-risk elderly patients. In a ...
(Date:6/16/2017)... , June 16, 2017 Datascope Corp. is voluntarily performing ... Corp. for a potential electrical test failure code.     ... PART NUMBER ... CS300 IABP 0998-UC-0446HXX; ... This ...
(Date:6/14/2017)... CALABASAS, Calif. , June 14, 2017 ... with the City of Fremont ... chain of the bio-pharma industry in California ... sharing technology, enabling executive networking, and fostering workforce development. ... the development and growth of start-ups, as well as ...
Breaking Medicine Technology: