Navigation Links
Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells

Philadelphia, PA (PRWEB) July 28, 2014

An estimated 68,000 women and men in the U.S. die each year from metastatic breast and prostate cancers – an aggressive form of the disease that occurs when the cancer has spread to other parts of the body, such as the lungs, liver, bones, or brain. Now researchers at Drexel University College of Medicine have developed a compound directed at a target they identified that inhibits metastatic progression by blocking tumor cells from “re-seeding.” Their discovery has been accepted into a highly competitive drug development program at the National Cancer Institute and will now be headed to clinical trials.

The chemokine target was initially discovered and validated in 2004 by cancer biologist Alessandro Fatatis, MD, PhD, professor in the Departments of Pharmacology & Physiology and Pathology & Laboratory Medicine at Drexel. But it would be several years before he began working with medicinal chemist Joseph Salvino, PhD, also a pharmacology professor at Drexel, and the two discovered that Salvino could develop a compound aimed at Fatatis’ target to produce a new therapy to treat cancer patients.

The compound works by targeting circulating tumor cells which leak into the blood producing new lesions, most commonly in the skeleton, therefore precipitating the progression of the disease. “Cancer cells in the blood survive only a few hours,” explains Fatatis. “They need to rapidly find a new home. What this compound does is block tumor cells from seeding again and again and pushes them toward a natural death in the blood.”

The compound specifically targets the chemokine receptor CX3CR1, which is expressed on circulating tumor cells and implicated in metastasis to the bone.

“A significant additional benefit is that the new compounds are not toxic,” adds Salvino. “We’re not talking about chemotherapy. We aim to develop a medication that someone could safely take in combination with their normal standard of care.”

The National Cancer Institute reviewed the discovery and deemed it scientifically meritorious to accept into its highly competitive Experimental Therapeutics Program (NExT), which gives the scientists access to the Institute’s drug discovery, preclinical and clinical development resources up to stage 2 clinical trials. The funding for this project is not yet finalized, but similar programs funded through NExT had budgets of approximately five million dollars.

The trials, which should begin in the next three to five years, will focus on advanced breast cancer patients with evidence of metastatic disease. But both scientists believe their discovery could have implications for other types of cancer as well, particularly prostate cancer.

“This really is a translational scientist’s dream come true,” said Fatatis, who as a medical doctor in addition to a PhD stressed the personal significance of working on something that could be brought from the bench to the clinic with the potential to make a real difference for patients.

Salvino adds, “This is the true definition of scientific collaboration. It’s not one isolated scientist in a lab. This is the result of scientists with different areas of expertise getting together and figuring out how to really make an impact.”


About Drexel University College of Medicine
Drexel University College of Medicine has established some of the most highly innovative and rigorous academic programs available today, incorporating the University’s expertise in engineering and technology into traditional medical training. The College of Medicine is home to one of the nation’s leading centers for spinal cord research; one of the foremost centers for malaria study; and a highly regarded HIV/AIDS program with extensive NIH-funded research in prevention and therapeutic interventions. Drexel University College of Medicine has been designated a Vanguard National Center of Excellence in Women’s Health by the U.S. Department of Health & Human Services, and is highly respected in numerous other specialties including cardiology and pain management. Follow Drexel University College of Medicine on Facebook, YouTube, Twitter and Instagram.

Read the full story at

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine
2. Abington Memorial Hospital to Become Regional Medical Campus for Drexel University College of Medicine
3. Scientists test nanoparticle alarm clock to awaken immune systems put to sleep by cancer
4. Brain Tumor Causes and Risk Factors Elude Scientists
5. Brain tumor causes and risk factors elude scientists
6. Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date
7. NIH-supported scientists demonstrate very early formation of SIV reservoir
8. Scientists Snipped HIV Out of Human DNA
9. Scientists Discover New Way to Make Human Platelets
10. Scientists find new clues to brains wiring
11. Scientists Spot Gene Behind Rare but Fatal Disease in Children
Post Your Comments:
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: