Navigation Links
Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells
Date:7/28/2014

Philadelphia, PA (PRWEB) July 28, 2014

An estimated 68,000 women and men in the U.S. die each year from metastatic breast and prostate cancers – an aggressive form of the disease that occurs when the cancer has spread to other parts of the body, such as the lungs, liver, bones, or brain. Now researchers at Drexel University College of Medicine have developed a compound directed at a target they identified that inhibits metastatic progression by blocking tumor cells from “re-seeding.” Their discovery has been accepted into a highly competitive drug development program at the National Cancer Institute and will now be headed to clinical trials.

The chemokine target was initially discovered and validated in 2004 by cancer biologist Alessandro Fatatis, MD, PhD, professor in the Departments of Pharmacology & Physiology and Pathology & Laboratory Medicine at Drexel. But it would be several years before he began working with medicinal chemist Joseph Salvino, PhD, also a pharmacology professor at Drexel, and the two discovered that Salvino could develop a compound aimed at Fatatis’ target to produce a new therapy to treat cancer patients.

The compound works by targeting circulating tumor cells which leak into the blood producing new lesions, most commonly in the skeleton, therefore precipitating the progression of the disease. “Cancer cells in the blood survive only a few hours,” explains Fatatis. “They need to rapidly find a new home. What this compound does is block tumor cells from seeding again and again and pushes them toward a natural death in the blood.”

The compound specifically targets the chemokine receptor CX3CR1, which is expressed on circulating tumor cells and implicated in metastasis to the bone.

“A significan
'/>"/>

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine
2. Abington Memorial Hospital to Become Regional Medical Campus for Drexel University College of Medicine
3. Scientists test nanoparticle alarm clock to awaken immune systems put to sleep by cancer
4. Brain Tumor Causes and Risk Factors Elude Scientists
5. Brain tumor causes and risk factors elude scientists
6. Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date
7. NIH-supported scientists demonstrate very early formation of SIV reservoir
8. Scientists Snipped HIV Out of Human DNA
9. Scientists Discover New Way to Make Human Platelets
10. Scientists find new clues to brains wiring
11. Scientists Spot Gene Behind Rare but Fatal Disease in Children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... (PRWEB) November 28, 2014 The ... techniques such as Dynamic Neuromuscular Stabilization, Extracorporeal Shock ... analysis. After moving to upgraded facilities in 2011, ... clinic. Now, owner Dr. Lev Kalika has launched ... injury prevention lab in the country. , The ...
(Date:11/28/2014)... The holiday season is fast approaching. As ... new collection of fashionable party dresses. What’s more, the company ... these brand new outfits; the special offer is valid until ... online supplier and it has received a lot of requests ... specially designed to flatter various body shapes; they are available ...
(Date:11/28/2014)... Brosix is always making changes to its infrastructure architecture ... efficient, effective, and secure experience. Most recently, the company ... ability to setup local servers for each country or ... around the globe. , 2. The ability to setup ... require millions of users in one network. , 3. ...
(Date:11/28/2014)... Orlando, FL (PRWEB) November 28, 2014 ... management solutions, announced its Release v5.1 which provides ... and enhanced workflow options. , “As we ... we continue to provide more functionality and improved ... states Robert Gambotz, CEO for Novatus. “With the ...
(Date:11/28/2014)... 2014 Dr. Diane Walder, one of ... treatment to her practice called Ultrashape that is designed to ... inches in just six weeks. Ultrashape has been praised by ... in results when compared to other types of external fat ... it,” said Dr. Walder. , According to Dr. Walder, ...
Breaking Medicine News(10 mins):Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 2Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 3Health News:Trendy Party Dresses For The Coming Holiday Season From Balfleet.com 2Health News:Brosix Infrastructure Architecture Changes to Benefit Users 2Health News:Novatus Releases v5.1 with New Advanced Reporting Capabilities 2Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 2Health News:Dr. Diane Walder Introduces New Fat Reduction Treatment Called Ultrashape 3
... Madhya Pradesh government has decided to implement a new ... through several 'anganwadis' (mother and child care centres). ... years are in full swing in the 59,324 anganwadis. ... an official of the women and child welfare department. ...
... better for children suffering from asthma compared to ... effectiveness and safety of different medicines. ... children control asthma, clinical trials directly comparing them ... Medical. ,For the first time, researchers ...
... review in the current issue of the Cochrane Library journal ... (ED) - Cialis, Levitra and Viagra appear to be safe ... in a family of medications called phosphodiesterase type 5 (PDE-5) ... of ED. Experts have estimated that the diabetic men ...
... talk of HIV/AIDS falling on deaf ears? ‘Careless’ is perhaps too ... to be completely in-charge of their lives, yet throw caution to ... survey has shown that, nearly three out of four women, do ... ,The Body Shop and MTV got together for a ...
... Schering-Plough fungus-fighter drug - Noxafil, //which gained FDA approval ... with crippled immune systems, according to two studies financed ... were published in the New England Journal of Medicine. ... known generically as posaconazole, also seems to have fewer ...
... all set to tighten the screws on smoking and ... hearing starting on Jan 23, is scheduled in which ... before the committee. ,Under the original act ... sports and other popular events by tobacco companies is ...
Cached Medicine News:Health News:ED Drugs - Safe and Effective for Diabetic Men 2
(Date:11/26/2014)... , Inc. (NASDAQ: BIOS ) announced today that ... at the Bank of America Merrill Lynch 2014 Leveraged Finance Conference ... , Wednesday, December 3, 2014 , , , , Time: ... Location: , , , Boca Raton Resort and Club, Florida , ... BioScrip, Inc. is a leading national provider of infusion and ...
(Date:11/26/2014)... -- Zynerba Pharmaceuticals , Inc., a specialty pharmaceutical ... cannabinoid treatments, today announced that the company will present ... The conference will be held December 2 to 3, ... York . Zynerba,s Chairman and CEO, Armando ... December 2. To listen to a webcast ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3
... /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: SSRX ) ... focused on researching, developing, manufacturing and marketing biopharmaceutical products, ... quarter and first half ended June 30, 2011. ... Total net revenues increased by 29.0% over the ...
... 2011 Vycor Medical, Inc. ("Vycor" or the "Company") ... fiscal quarter ended March 31, 2011, the year ended ... 2010, June 30, 2010 and September 30, 2010 and ... Company,s periodic reports filed with the Securities and Exchange ...
Cached Medicine Technology:3SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 23SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 33SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 43SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 53SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 63SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 73SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 83SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 93SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 103SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 113SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 123SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 133SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 143SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 153SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 163SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 173SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 183SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 19Vycor Medical, Inc. Restatement of Financial Statements 2Vycor Medical, Inc. Restatement of Financial Statements 3
... Centuries of German Craftsmanship have ... in the world. Ocutek® now ... Only holders of the coveted ... eight-year apprenticeship, are qualified to ...
... of German Craftsmanship have produced ... the world. Ocutek® now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
... Craftsmanship have produced the finest ... Ocutek now makes them available ... the coveted Meisterbrief certificate, which ... qualified to become Ocutek instrument ...
1mm by 7mm horizontal punch. Flat serrated handle. Overall length 87mm....
Medicine Products: