Navigation Links
Dream team targets key driver for breast, ovarian, endometrial cancers
Date:5/27/2009

dical School, and co-leader Charles Sawyers, M.D., director, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center in New York. The Dream Team also includes research groups at Vanderbilt-Ingram Cancer Center, Vall d'Hebron Oncology Research Institute in Barcelona, and Herbert Irving Comprehensive Cancer Center at Columbia University.

The PI3K network normally promotes cell survival, growth and protein synthesis. When it is abnormally activated by genetic aberrations, it contributes to tumor progression, connects to other cancer-causing pathways and causes resistance to treatment.

The team will use its combined cell line studies, animal model research and data from drugs that have completed phase I clinical trials to identify potential biomarkers - specific genetic mutations in patients' tumors, for example - that will indicate whether a drug will work for specific groups of patients.

Clinical trials of the targeted drugs also will test the validity of candidate biomarkers. Mills, who also directs the Kleberg Center for Molecular Markers at M. D. Anderson, expects the first phase II clinical trial, for endometrial cancer, to open in about six months.

Mills leads the team's tumor cell line and screening core, which will analyze every tumor sample to detect cancer-related genetic mutations, study the effect of genetic aberrations on the PI3K pathway and on PI3K inhibitors used in clinical trials, and identify drug combinations to block the pathway and biomarkers related to those drugs.

Combinations will likely be needed both to stifle the PI3K pathway and to inhibit a second interacting pathway, the MAPK/RAS network. Early cell line and animal model evidence suggest both pathways must be blocked to effectively treat the three cancers.

Also on the Dream Team from M. D. Anderson are Donald Berry, Ph.D., head of the Division of Quantitative Biology; Cheryl Lyn Walker, Ph.D., professor in
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Billians HealthDATA GM Speaking on Dreamforce 07 Panel
2. Serta Brings Sweet Dreams and a Special Delivery to Deserving Women
3. The Emerald Dream Ball
4. Vote Online to Help One Lucky Family Win a Dream Home Makeover
5. Design-her Gals(TM) Announces the Ground-Breaking Virtual On-Line Walk for Wishes to Grant Dreams for Stage IV Breast Cancer Patients this Holiday Season Through Gal to Gal Foundation
6. This Holiday Season Some Dream of a White Christmas - The Accelerated Cure Project Dreams of Developing a Cure for Multiple Sclerosis
7. Gilbert Pritchard, Jr. Joins Board of Directors at Dreamerz Foods, Inc.
8. 9/11 Attacks Changed Way Americans Dream
9. Helping the Severely Wounded Learn How to Dream Again
10. Photo: Sweet Dreams From Turkey
11. 21 Days to Creating Your Dream Life Will be Unleashed on April 28, 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dream team targets key driver for breast, ovarian, endometrial cancers
(Date:7/13/2014)... According to the Kidney Disease Solution book review recently updated ... what to do to eliminate the root cause of ... review that readers can easily learn what foods to avoid ... Vkool also informs in its Kidney Disease Solution review that ... naturally. The book consists of a collection of natural remedies ...
(Date:7/13/2014)... Celebrity fitness trainer and former World Super ... with Aqua Health Labs for their flagship product PhytOriginal, ... The collaboration was recently announced live on ESPN Radio. ... actor, model, and a two time World Super Middleweight ... has prepared stars including Demi Moore, Hilary Swank and ...
(Date:7/13/2014)... July 13, 2014 If Dr. Lawrence Power ... has just launched at http://www.HealthYourself101.com will expand people’s ... , Power has set out to provide a health ... that’s actually – dare we say it? – entertaining to ... Power, “aims to engage the remote learner – the solitary ...
(Date:7/13/2014)... Recently, iFitDress.com, one of the most popular suppliers ... added a new selection of beautiful evening dresses ... a promotion for these evening gowns. Now, everybody can ... providing thousands of graceful gowns in its online store. ... France, Italy and many other countries. They are highly ...
(Date:7/12/2014)... (PRWEB) July 13, 2014 Recently, iFitDress.com, one ... new selection of red evening gowns . What’s more, ... to 56% off. , The company’s senior spokesman states, “We ... shopping on our website is an enjoyable shopping experience. In ... In our online store, low prices do not always mean ...
Breaking Medicine News(10 mins):Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 2Health News:Kidney Disease Solution Book Review Exposes Duncan Capicchiano's Newly Updated Kidney Disease Treatment Plan – Vkool.com 3Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:New and Beautiful Evening Dresses Unveiled by iFitDress.com 2Health News:Discounted Red Evening Gown Announced by iFitDress.com 2
... a hospitalization, patients are seen by a variety ... has primary responsibility for their care. However, faulty ... or other problems may keep the specialists, recommendations ... study by Martin Were, M.D., of the Regenstrief ...
... Ltd. will be unveiling a new diagnostic ultrasound system ... to be held from March 6th, 2009 in Vienna, ... with higher cost-effectiveness, flexibility, ease of use, and functionality. ... with the latest digital technologies engineered into a compact ...
... Legislation Report Card Ranks State Efforts: Finally, More "A,s" ... time, more U.S. states have received A grades than ... the 2009 Colorectal Cancer Legislation Report Card. Issued ... groups and medical professional societies, the report card was ...
... AP LIS to Interface with BioImagene,s Virtuoso(TM) ... 6 Impac Software, part of the ... solutions for anatomic pathology (AP) laboratories, and ... today announced the development of an interface ...
... headsets contaminated with bacteria that could infect patients ... new culprit has emerged in the spread of ... hospitals -- mobile phone headsets. , Turkish researchers ... in hospitals found that 95 percent were contaminated ...
... Valeant Pharmaceuticals (NYSE: VRX ) today announced that ... 12, 2009 at 9:00 a.m. Eastern Time, at the Hilton ... New Jersey 07078. The record date for stockholders entitled ... About Valeant , Valeant Pharmaceuticals International (NYSE: VRX ...
Cached Medicine News:Health News:Giving doctors the complete picture 2Health News:ALOKA Showcases a New Diagnostic Ultrasound System ProSound 4 at ECR 2009 in Vienna, Austria 2Health News:New Data Reveals That Gaps in Coverage for Those With Private Insurance Are Major Barriers to Colorectal Cancer Screening 2Health News:New Data Reveals That Gaps in Coverage for Those With Private Insurance Are Major Barriers to Colorectal Cancer Screening 3Health News:New Data Reveals That Gaps in Coverage for Those With Private Insurance Are Major Barriers to Colorectal Cancer Screening 4Health News:New Data Reveals That Gaps in Coverage for Those With Private Insurance Are Major Barriers to Colorectal Cancer Screening 5Health News:New Data Reveals That Gaps in Coverage for Those With Private Insurance Are Major Barriers to Colorectal Cancer Screening 6Health News:Impac Software and BioImagene Develop Workflow Solution for Digital Pathology and the Laboratory Information Systems 2Health News:Impac Software and BioImagene Develop Workflow Solution for Digital Pathology and the Laboratory Information Systems 3
(Date:7/11/2014)... -- Neurelis, Inc. ("Neurelis") today announced an agreement with ... by Biotie to purchase Neurelis, clearing the way for ... for pediatric and adult epilepsy patients who experience acute ... has advanced the development program for NRL-1 and worked ... required for NDA submission to the FDA.  Given the ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
(Date:7/10/2014)... JORDAN, Utah , July 10, 2014  BC ... solutions, and MiE America , Inc., a leading ... have entered into a long-term agreement naming BC Technical ... the US. MiE and BC Technical ... strategic agreement to establish BC Technical as the service ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... Inc. today announced that it has been awarded a ... $600,000 from the National Institute of Allergy and Infectious ...  The grant will be used to demonstrate the feasibility ... platelet recovery and improve survival in a mouse model ...
... TOPEX, Inc. announces the sale of its skin cancer ... energy SRT 100 superficial radiotherapy treatment system. Since TOPEX ... operating worldwide at hospital radiation oncology centers, dermatology and ... The low energy superficial radiotherapy system provides patients an ...
Cached Medicine Technology:Bolder BioTechnology Announces $600,000 Grant from NIH to Study Long-Acting IL-11 Analog in Treating Acute Radiation Syndrome 2TOPEX Sells Skin Cancer Business Operations to SENSUS Healthcare 2
Each solid state catheter kit below is supplied with adapter cable(s) for Polygraf ID and a Manometric Calibrator....
... water perfused manometric catheters for ... diagnostic tests. All Medtronic Water ... clear, medical grade PVC tubing. ... esophagus you will find a ...
... Catheters make motility testing simpler ... catheters set up in seconds ... with every sensor circumferential, Air-Charged ... anatomical irregularities. For advanced performance ...
Esophageal Stylet for LATITUDE® Air-Charged Catheter...
Medicine Products: