Navigation Links
Dr. Roger Reeves, 2012 Sisley-Jérôme Lejeune Prize Winner, Significantly Advances Understanding of the Biology of Down Syndrome Leading to New Avenues of Research

Philadelphia, PA (PRWEB) September 12, 2013

The Jérôme Lejeune Foundation welcomes the results obtained by Professor Roger Reeves, recipient of the 2012 Sisley-Jérôme Lejeune Prize, recently published in the journal, Science Translational Medicine (Sept.4, 2013). This work marks another significant development in understanding intellectual disability, particularly Down syndrome, and pathways to the development of potential therapies to improve the lives of those affected by them. The Jérôme Lejeune Foundation continues its mission of supporting research into genetic intellectual disability, encouraged by the rapid pace of progress made by researchers in recent months.

In receiving the Sisley -Jérôme Lejeune award last November at the Museum of Medicine in Paris, Dr. Reeves announced to those present that his contributions were not completed, and that the best was yet to come. With his research team at Johns Hopkins University, and in partnership with researchers at the National Institutes of Health, he has announced the identification of a substance capable of normalizing the development of the cerebellum in a mouse model of Down syndrome with just a single injection. The result is improved memory and learning.

Dr. William Mobley, Chair of the Department of Neurosciences at the University of California, San Diego, and Chair of the Jérôme Lejeune Foundation USA Scientific Advisory Board commented that this is "Interesting and important work raising the possibility that Shh signaling deficits feature in the cerebellar and hippocampal abnormalities in a mouse model of DS”. Dr. Mobley believes that “The work will stimulate new studies as to how this signaling pathway is impacted”, and further commented that, “While the authors do not envision the agent they used in mice would be appropriate for clinical studies in humans, they point to the possibility that similar pathways may be therapeutically targeted in people with Down syndrome."

Dr. Reeves’ announcement follows other recent developments in this area of research. In July, Dr. Jeanne Lawrence of the University of Massachusetts announced that her lab had silenced the extra 21st chromosome in human induced pluripotent stem cells by introducing the XIST gene. In November a team of researchers at the University of Washington announced similar news of a technique to remove the extra 21st chromosome in their lab. Also, on the clinical front, in July, a Japanese pharmaceutical company launched a clinical trial to test a drug usually used for Alzheimer's disease for the benefit of people living with Down syndrome, and even more recently, a phase 2a study has just begun on a drug developed by the Irish pharmaceutical company, Elan, which is hoped will improve everyday cognitive function of individuals with Down syndrome.

The Sisley - Jérôme Lejeune Prize has been awarded to leading researchers since 2010. It is intended to acknowledge significant contributions and personal commitment to improving the lives of those living with genetic intellectual disabilities, and to bring notoriety and encouragement to them in their work. The first prize was given to Dr. Mara Dierssen of the Center for Genomic Regulation in Barcelona in 2010, Since then, American researchers have been the recipients. Dr. Wiliam Mobley from the University of California, San Diego in 2011 and Dr. Roger Reeves in 2012 . The fourth edition of the Sisley -Jérôme Lejeune Prize will be awarded on October 17 in Paris to two exceptional senior researchers, one French and the other American. Three young talented researchers will also be acknowledged.

The Jérôme Lejeune Foundation is the world’s largest private funder of research into Down syndrome and other genetic intellectual disabilities providing approximately $5 million annually to fund it’s own research program, clinical trials, and other researchers working in countries throughout the world to improve the lives of those living with genetic intellectual disabilities. Founded in Paris by the Lejeune family after the death of Jérôme Lejeune, the geneticist who discovered the genetic cause of Down syndrome, the Foundation’s mission is directed toward research, care and advocacy for those with genetic intellectual disabilities. The Foundation has offices in Paris and Philadelphia.

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Dentist in Arlington, VA, Dr. Michael Rogers Launches New Website
2. InnovaNet Group Expands West Coast Presence with the Addition of Roger Barata and Steve Kaplan
3. MentorMate Appoints Roger Ferguson as its Vice President of Professional Services
4. Jackson, MS Periodontist, Dr. Roger Parkes Brings Gum Disease Patients the FDA-cleared Laser Gum Disease Treatment
5. Fitness Franchise Fit Body Boot Camp Opens First Saskatchewan Location and Announces Lloydminster Personal Trainer Michele Rogers as Owner
6. Anne Miner, Hosts New Rogers Community TV series "Women of Courage"
7. Dr. Roger D. Weiss earns Hazeldens Dan Anderson Research Award
8. Nobel laureate Roger Tsien, Ph.D., keynotes Cedars-Sinai nanomedicine conference March 15, 16
9. Rogers Athletic Company Donates Fitness Equipment to Eagle Village
10. The Jerome Lejeune Foundation, USA Joins Advocacy Organizations Worldwide to Say: Down Syndrome - So What!
11. U.S. Army Veteran and Caregiver for Seniors is Grand Prize Winner of Caring Champion Contest
Post Your Comments:
(Date:11/27/2015)... ... ... The print component of “Supporting Our Caregivers” is distributed ... Minneapolis, South Florida, with a circulation of approximately 250,000 copies and an estimated ... media strategy and across a network of top news sites and partner media ...
(Date:11/27/2015)... ... 27, 2015 , ... Consistent with the Radiology Business ... Better Radiology Marketing Programs meeting will showcase some of the best 2015 ... Caesars Palace in Las Vegas with a pre-conference session on a collaborative approach ...
(Date:11/27/2015)... ... November 27, 2015 , ... The ... prided itself for not only fulfilling the needs of advisers and clients but ... affordable price and providing top-tier customer service. However, there's always room for improvement, ...
(Date:11/27/2015)... Chicago, IL (PRWEB) , ... November 27, 2015 ... ... some of the largest, most successful and prominent nonprofit healthcare organizations in the ... and governance involvement with various organizations, and helped advance the healthcare industry as ...
(Date:11/27/2015)... ... 27, 2015 , ... Indosoft Inc., developer and distributor of ... 11 LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making ... with a version of Asterisk that will receive not only security fixes, but ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 2015 --> ... online. The potential to save costs, improve treatment quality ... from fully exploited as yet. Here, particular emphasis is ... via mobile tablet or directly at the patients, bedside. ... ) -->      (Photo: ...
(Date:11/27/2015)... DUBLIN , Nov. 27, 2015 Research ... of the "Global Intrauterine Devices Market 2015-2019" ... --> In this report, the author ... intrauterine devices market for 2015-2019. To calculate the market ... of following type of products: Hormonal IUDs and copper ...
(Date:11/26/2015)... UTRECHT , Países Bajos, November 26, 2015 /PRNewswire/ ... con la terapia fotodinámica de Bremachlorin para el cáncer ... combina la inmunoterapia con la terapia fotodinámica de Bremachlorin ... Un nuevo enfoque combina la inmunoterapia con la ...   Clinical Cancer Research . --> ...
Breaking Medicine Technology: