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Dr. Mei honored by mental health research charity for schizophrenia studies
Date:4/24/2008

Studies of how brain cell communication may be altered in schizophrenia have earned Dr. Lin Mei, chief of developmental neurobiology at the Medical College of Georgia, a 2008 Distinguished Investigator Award from NARSAD.

Dr. Mei, Georgia Research Alliance Eminent Scholar in Neuroscience and professor in the MCG School of Medicines Department of Neurology, is one of 11 scientists to receive the award, which includes a $100,000 one-year grant from the worlds leading charity dedicated to mental health research.

He has found that two genes, important for human development and implicated in other disorders including cancer and seizures, normally enable a healthy balance of brain cell excitation and inhibition. In 2007, Dr. Meis lab showed neuregulin-1 and its receptor, ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter. Seven years earlier, he led a team that showed that the gene pair suppresses synapses between neurons where the neurotransmitter glutamate excites cells to action. According to our model, it inhibits, Dr. Mei says of neuregulin-1.

Schizophrenia has been labeled a degenerative disease where neurons die and a developmental disease where the wiring is laid wrong. Dr. Meis research shows problems in neuron communication, likely also are to blame. Its a complex disease, says Dr. Mei in which neuregulin-1 expression is off balance, possibly the result of mutations in the neuregulin-1 gene.

He believes even a subtle imbalance in brain cell excitation and inhibition helps explain the cognitive problems in schizophrenia and possibly other disease hallmarks of hallucinations and social disconnection. He also believes that correcting the imbalance is doable. Say neurotransmission is high: you could try to suppress it. If low, you could try to stimulate it.

Dr. Mei already has inhibitors and activators in his lab refrigera
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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

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Dr. Mei honored by mental health research charity for schizophrenia studies
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