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Dr. Lewis Cantley awarded $3 million breakthrough prize in life sciences
Date:2/21/2013

ecently, Dr. Cantley's research has focused on characterizing the mechanism by which PI3K is activated by growth factors and cancer-causing oncogenes, and elucidating PI3K's pathways, including Akt/PKB -- critical proteins that regulate cell survival and proliferation in normal and cancer cells. In the course of his work, Dr. Cantley's laboratory has revealed the structural basis for regulated interaction of these signaling proteins, and this technique has led to a bioinformatics approach for predicting signaling pathways on the basis of gene sequences.

Dr. Cantley is currently exploring the role of the PI3K pathway in cancer and diabetes. In 2011, he was awarded a $15 million grant from Stand Up 2 Cancer to lead a team of researchers to bring new cancer treatments to patients faster by investigating the role of PI3K in the development of breast, ovarian and endometrial cancers.

Dr. Cantley graduated summa cum laude in 1971 with a Bachelor of Science degree in chemistry from West Virginia Wesleyan College and obtained a Ph.D. in biophysical chemistry from Cornell University in 1975. He conducted postdoctoral research at Harvard University from 1975 until 1978, when he was appointed assistant professor of biochemistry and molecular biology at Harvard University's Faculty of Arts and Sciences. Dr. Cantley was appointed as professor of physiology at Tufts University in 1985, but returned to Harvard Medical School as professor of cell biology in 1992, a position he held until 2003.


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Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

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