Navigation Links
Dr. Arun Sreekumar lectures on new candidate biomarker at Annual EAU Congress
Date:3/10/2009

Arnhem, 10 March 2009 -- The standard Prostate Specific Antigen (PSA) test for prostate cancer cannot tell the difference between aggressive and slow-growing forms. At the Annual EAU Congress, which will be held from 17 to 21 March 2009 in Stockholm (SE), Dr. Arun Sreekumar - University of Michigan (US) - will report about a possible breakthrough biomarker that can supposedly discriminate between aggressive and non-aggressive prostate cancers: sarcosine.

"The PSA test," explained Dr. Sreekumar to US media, "is the clinical standard test, but it has a very high false positive rate." Sreekumar underlined that there is a danger to overtreat some patients or not to treat others. Quite often men have PSA scores that fall into a grey area. Then an invasive biopsy is needed to clarify a diagnosis. But even when a biopsy reveals cancer, it sometimes remains unclear whether the cancer is aggressive or indolent. Thus a biopsy does not always reveal who needs aggressive treatment.

Dr. Arun Sreekumar and his team of the University of Michigan measured the levels of chemical by-products, metabolites, of the reaction inside the human cells. Ten metabolites were found at much higher levels in prostate cancer than in normal samples and one of these metabolites stood out: sarcosine. Sarcosine can be identified in urine, which makes a possible test less invasive than PSA test, which requires a blood analysis.

The findings suggest that not only is sarcosine a marker of cancer aggressiveness, it also has a role in endowing a cancer with malignant properties. Sarcosine may distinguish slow-growing prostate cancers from those likely to spread and become lethal. On the other hand benign prostate cells take on cancerous characteristics in lab dishes when exposed to sarcosine.

"Metabolic profiles delineate potential role for sarcosine in prostate cancer progression" is the title of Sreekumar's scientific article published in Nature recently (Nature, 457, 12 February 2009: 910-914). The research of Sreekumar and his team looked at more than 1,000 metabolites, or small molecules, in tissues associated with prostate cancer.

Dr. Arun Sreekumar, 37-year old lead author of the publication, recently started his new assistant professorship at the Medical College of Georgia Cancer Research Center. His work has been aiming at finding non-invasive ways to identify prostate cancer and predict its aggressiveness.


'/>"/>

Contact: Lindy Brouwer
l.brouwer@uroweb.org
0031-263-890-680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. Ramsey, N.J. Therapists Lectures to International Medical Professionals & Provides Treatment to Professional Athletes at Home and Abroad
2. Childhood Obesity Expert Dr. William Dietz Featured at the 2nd Annual Michael & Susan Dell Lectureship in Child Health
3. Plenary lectures announced for worlds largest osteoporosis congress
4. FDA Clears Cellectars IND Application for Lead Drug Candidate
5. Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate
6. Pharmacy Technician Certification Board (PTCB) Unveils New Testing Features for 2009: PTCB Exam to be Offered Daily; Test Results Given to Candidates Immediately in 2009
7. InNexus Biotechnology Completes Preclinical Study Confirming in Vivo Effectiveness and Safety of Lead Candidate DXL625, Schedules Meeting With FDA
8. New Criteria Could Expand Number of Liver Transplant Candidates
9. Alexza Reports 2008 Third Quarter Financial Results and Updates Development of Product Candidates
10. Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches
11. In Final 72-Hour Push, SEIU Members Get Out The Vote for Barack Obama and Other Working Family Candidates Across the Country
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... a number of ,world firsts,: , TwinLink™ ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: