Navigation Links
Doxorubicin alone or with ifosfamide for treating soft tissue sarcoma?
Date:3/25/2014

An EORTC study published in The Lancet Oncology does not support administration of intensified doxorubicin and ifosfamide for palliation of advanced soft tissue sarcoma, unless the objective is to shrink the tumor.

Dr. Ian Judson of the Royal Marsden Hospital in London and coordinator of this study says, "Our clinical trial was designed to compare combination treatment with doxorubicin and ifosfamide to treatment with doxorubicin alone, and our results show that the combination chemotherapy did not improve overall survival. So, if the goal of treatment is to control the disease, then administering doxorubicin alone is appropriate. On the other hand, if the goal is to shrink the tumor before another intervention or to relieve symptoms, then combination treatment is justifiable. The observed lack of improvement in overall survival points to the need for better treatments for patients with this disease."

For some thirty years, patients with soft tissue sarcomas have been treated with doxorubicin and ifosfamide, but few studies have directly assessed whether doxorubicin should be administered alone or in combination with ifosfamide. EORTC trial 62012 assessed whether the addition of ifosfamide to doxorubicin improves survival of patients with advanced soft-tissue sarcoma compared with doxorubicin alone.

Between April 2003 and May 2010, EORTC trial 62012 randomized 455 patients aged 18 to 60 years with unresectable locally advanced or metastatic high-grade soft-tissue sarcoma to receive either doxorubicin alone (228 patients) or intensified doxorubicin plus ifosfamide (227 patients, combination group) as first-line treatment. At a median follow-up of 56 months in the doxorubicin alone group and 59 months in the combination group, no significant difference was observed in median overall survival (12.8 months [955% CI 105 - 143] in the doxorubicin alone group and 14.3 months [12.5 16.5] in the combination group; hazard ratio [HR] 0.8
'/>"/>

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Loneliness, Living Alone Might Shorten Life
2. Obesity Alone May Not Hurt Kids Classroom Performance
3. Early use of stents better than medical therapy alone for certain patients
4. Cancer-causing gene alone doesnt trigger pancreatic cancer, Mayo-led study finds
5. With food insecurity rising in US, SNAP benefits should be left alone
6. Assessment of HPV DNA alone insufficient to identify HPV-driven head and neck cancers
7. Want to Get Rid of That Old Tattoo? Youre Not Alone
8. Malecare and CancerMatch.com announce the launch of Facing Cancer Alone
9. Using mouthrinse reduces plaque and gingivitis more than toothbrushing alone
10. Affordable care alone may not be enough to help Latinos overcome cancer care barriers
11. Hate Other Peoples Cellphone Calls? Youre Not Alone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 2014 -- Recent two-generation approaches to reducing poverty ... increasing attention from researchers, advocates, and foundations. By ... them to move to jobs that offer a ... and education for children, these programs aim to ... according to a new report from the National ...
(Date:9/22/2014)... 2014. Kessler researchers have published a pilot study ... program in people with multiple sclerosis (MS). ... perceived stress, and pain. "Development and effectiveness ... with MS: Description and outcomes" was epublished ahead ... International Journal of MS Care (doi: 10.7224/1537-2073.2013-045). ...
(Date:9/22/2014)... 22, 2014 The Workgroup ... leading nonprofit authority on the use of health ... announced findings from its recent industry survey on ... (HPID) within electronic transactions adopted under the Health ... the survey from August 20 to September 5, ...
(Date:9/22/2014)... MONDAY, Sept. 22, 2014 (HealthDay News) -- Scans ... they learn to read. This finding could potentially ... other reading difficulties early on, preliminary research suggests. ... in children with dyslexia as well as most ... Hoeft, an associate professor of child and adolescent ...
(Date:9/22/2014)... Barbara Bronson Gray HealthDay ... It,s something every pregnant woman wonders: What can I do ... that taking iron supplements as prescribed may play a role ... spectrum disorder (ASD). The researchers found that mothers of ... iron supplements before and during pregnancy than those whose children ...
Breaking Medicine News(10 mins):Health News:A two-generation lens: Current state policies fail to support families with young children 2Health News:WEDI Announces Survey Results from Unique Health Plan Identifier (HPID) Industry Poll 2Health News:WEDI Announces Survey Results from Unique Health Plan Identifier (HPID) Industry Poll 3Health News:Can Brain Scans Help Predict Young Children's Reading Abilities? 2Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 2Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 3
... Centers for,Medicare & Medicaid Services (CMS) has selected the ... data analysis,services to detect potential fraud and waste in ... task order to help identify inappropriate,and unnecessary Medicaid payments ... MIP was created as a result of the federal ...
... MED, CEO DeCODE Genetics, WASHINGTON, June 5 ... Cardiovascular Institute:, Date: Thursday, June 12, 2008, ... 23rd Street, NW, Time: Noon - 2:50pm, ... Dr. Stefansson is CEO and co-founder of deCODE genetics ...
... MA Researchers from Boston University School of Medicine (BUSM) ... among Medicare beneficiaries at the end of life. The ... Internal Medicine. , According to researchers, medical treatments for ... year comprise almost 30 percent of Medicare expenditures. In ...
... Visit Denver to Rally Residents to Eat Right, Move More and ... Milk ... by the,ups and downs of different fad diets -- which seem to go ... been,slim. Two out of three Americans remain overweight or obese., A new ...
... and Indiana Fever for an evening of celebration, INDIANAPOLIS, ... will be honored by the March of Dimes on June ... collaboration to help families,with critically ill babies throughout the state ... walk., For several years, Anthem has teamed up with ...
... enable sexual maturity and fertility make a critical journey: from ... the brain. , They believe their studies in the ... neurons don,t make it and enable better ways to help ... "They can go to the right place but take too ...
Cached Medicine News:Health News:CMS Selects Thomson Reuters to Help Detect Medicaid Fraud in Eight States 2Health News:Genomics of Cardiovascular Disease: Current Clinical Applications 2Health News:Primary care visits reduce hospital utilization among Medicare beneficiaries at the end of life 2Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 4Health News:Anthem Blue Cross and Blue Shield Honored by March of Dimes 2Health News:Zebrafish enable scientists to study the migration of neurons that enable sexual maturity 2Health News:Zebrafish enable scientists to study the migration of neurons that enable sexual maturity 3
(Date:9/22/2014)... NEW YORK , September 22, 2014 ... New Market Report on "Global Market Study on Ophthalmic ... Growth by 2020," the global ophthalmic devices market was valued at ... grow at a CAGR of 6.5% from 2014 to ... million in 2020. Browse the full Global Market ...
(Date:9/22/2014)...  Neuralstem, Inc. (NYSE MKT: CUR) announced that ... University, presented long-term follow up data on the Phase ... the treatment of amyotrophic lateral sclerosis (ALS or ... the Annual Symposium on ALS of the Foundation Andre-Delambre, ... and was not open to the public, covered data ...
(Date:9/22/2014)... PHOENIX , Sept. 22, 2014  For ... wrists, surgery often means facing the prospect of ... can be imagined, regular activities are also impacted, ... on the severity of the problem, some patients ... braces, which can even lead to permanent damage ...
Breaking Medicine Technology:Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4Phoenix Arizona Hand Doctor Develops Revolutionary New Surgery System, Eliminates Need for Large Incisions 2
... (Nasdaq: BMRN ) today announced that Joshua Grass, ... a company update at the UBS Global Life Sciences Conference ... 3:30 p.m. ET.   Interested parties may access ... investor section of the BioMarin website, www.BMRN.com .  A ...
... Arcion Therapeutics , a venture backed clinical stage ... announced that the U.S. Food and Drug Administration (FDA) ... treatment of pain associated with Painful Diabetic Neuropathy (PDN). ... for topical administration. Arcion recently announced positive ...
Cached Medicine Technology:BioMarin to Present at the UBS Global Life Sciences Conference 2Arcion Therapeutics Receives FDA Fast Track Designation for ARC-4558 for the Treatment of Pain Associated with Painful Diabetic Neuropathy 2
... For enzyme immunoassays, designed to meet the ... and allows the user to run set ... The floating manifold on this strip washer ... at a time. Reliable, compact, and self-contained, ...
... available to handle multiple assays: ... Embla 384 Cell washer has ... optimized to avoid cell disturbance. ... and have been integrated with ...
... miniGene LW is a new plate washing system ... and 384 channel microplates with flat, V-shaped or ... 8 or 16 channel nozzle heads. Simple LCD ... An optional plate stacker is available for the ...
Space-saving counter top model,User initiated manual defrost,Standard features (see above),Internal freezing compartment,Removable half-shelf in refrigerator,Two shelves in door,UL 471 Commercial Ref...
Medicine Products: