Navigation Links
Doubt Cast on Use of Genetic Test Before Plavix
Date:12/28/2011

WEDNESDAY, Dec. 28 (HealthDay News) -- A new review of existing research suggests that, despite a federal recommendation, genetic testing won't help physicians determine which heart patients should get Plavix, a blood-thinning drug used to treat certain cardiac conditions.

Plavix, also known as clopidogrel, is used to treat or prevent blood clots due to the clogging of arteries and after such surgical procedures as balloon angioplasty.

But some patients won't experience the drug's clot-preventing benefits if their bodies don't process it properly, potentially leading to heart attack, blood clots in stents and death, according to Dr. Jean-Sebastien Hulot, associate professor of medicine at the Cardiovascular Research Center at Mount Sinai School of Medicine. Or, he said, they could experience the reverse -- excessive bleeding if the medication has too much of an effect. Hulot was not involved with the study, but is familiar with the findings.

The U.S. Food and Drug Administration believes that genetic testing could help identify patients who won't respond well to the drug. But the American Heart Association and the American College of Cardiologists have been skeptical that the genetic testing in question is useful.

In the new review, Dr. Michael V. Holmes of University College London and colleagues examined 32 studies that included over 42,000 patients. They looked for signs of bleeding problems, blood clots in stents and cardiovascular problems.

They also conducted a meta-analysis in which they examined statistics in the studies as a whole.

While they mention some statistical caveats, the researchers found that a specific genetic trait -- linked to the body's ability to respond to the drug -- did not significantly affect the risk of cardiovascular problems.

In a commentary accompanying the study, Dr. Steven E. Nissen, borrowing a phrase from a former chairman of the Federal Reserve, wrote, "It now appears that the FDA warning reflected a case of 'irrational exuberance.'"

Nissen, chair of cardiovascular medicine at the Cleveland Clinic, noted that the review has limitations. But, he added, for the time being physicians should "rarely, if ever" use the genetic testing in question and should "interpret the results with caution."

Hulot, the Mount Sinai School of Medicine professor, is skeptical. He said the findings are "far from convincing" and questioned their statistical validity. He also pointed to an earlier study, also a meta-analysis, that suggested a genetic trait did indeed boost the risk of problems for those who took the drug in certain cases.

The study is published in the Dec. 28 issue of the Journal of the American Medical Association.

More information

For more on Plavix (clopidogrel), visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Jean-Sebastien Hulot, M.D., Ph.D., associate professor of medicine and director, Pharmacogenomics & Personalized Therapeutics, Cardiovascular Research Center, Mount Sinai School of Medicine, New York City; Dec. 28, 2011, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Casts Doubt on Hospice Admission Criteria for Patients With Dementia
2. Lifesaving antibiotics face doubtful future
3. Intensive care nurses have doubts about method for establishing brain death
4. New Report Casts More Doubt on Virus Link to Chronic Fatigue Syndrome
5. Study Casts Doubt on Hot Dogs Link to Colon Cancer
6. Requests for Alzheimers disease research grants up by 33 percent, as federal funding in doubt
7. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
8. Obstructive Sleep Apnea in Kids May Have Genetic Cause
9. Epigenetic signals differ across alleles
10. Study reveals genetic link between mammographic density and breast cancer
11. Genetic Risk Score Doesnt Spot Heart Trouble in Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Doubt Cast on Use of Genetic Test Before Plavix
(Date:2/24/2017)... ... February 24, 2017 , ... Rosica Communications, a national ... leadership , media relations, social media, content marketing and SEO, is now offering ... Act-On, an intuitive marketing automation platform. , Rosica will now offer the platform ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... Charlevoix, once again hosted their Military Wedding Giveaway, with the winning couple announced ... Castle Farms with services generously donated from local vendors: A Matter of Taste, ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February 22, 2017 ... letter to withdraw previous guidance issued by the Obama Administration requiring schools ... in May 2016 by the Obama Administration came in response to a growing ...
(Date:2/23/2017)... Miami, FL (PRWEB) , ... February 23, 2017 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – will return to the La Gorce Country Club in Miami Beach ...
(Date:2/23/2017)... Hill, NC (PRWEB) , ... February 23, 2017 , ... ... Platinum Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter of ... 2017 as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA President. ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Regulus Therapeutics Inc . (Nasdaq: RGLS), ... innovative medicines targeting microRNAs, today announced it will release ... Thursday, March 2, 2017 after the market closes. ... on March 2, 2017 at 5:00 p.m. Eastern Time ... results and provide a general business update.  A live ...
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... & Trends - Industry Forecast to 2025" report to their ... The ... around 6.9% over the next decade to reach approximately $47.6 billion ... estimates and forecasts for all the given segments on global as ...
(Date:2/23/2017)... WASHINGTON , Feb. 23, 2017  As ... tips.  In addition, the Company is helping people ... through its customized prescription savings programs in all ... Florida Prescription Assistance Program  and  California Prescription Assistance ... tips from Columbia University for nutritious ...
Breaking Medicine Technology: