Navigation Links
Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
Date:6/7/2012

A new study in the journal Circulation packs a powerful one-two punch in the fight against heart failure. The leading blow: Identification of a unique alliance of proteins that plays a major role in the development of the disease. The second but equally powerful hit: Drugs that interfere with this axis already exist.

Though still in its infancy, the combination is just the type of research the scientific community is looking for in its efforts to speed up the development of the next generation of treatments for the nation's biggest killers, of which heart disease is the long-reigning champ.

Burns C. Blaxall, Ph.D., FAHA, of the University of Rochester Medical Center, led the research team to the discovery, which revolves around adrenaline, the hormone that regulates rate and strength of the heart and causes our hearts to beat furiously in a crisis. Adrenaline levels are constantly ramped in people with heart failure the body's attempt to recharge a weakened heart. While decades of research have established a connection between elevated adrenaline and heart failure, there is still much to learn about how it contributes to the disease.

In a mouse model of heart failure, Blaxall's team found that chronically high levels of adrenaline spur a bad actor a protein called PAR1 into gear. Several years ago, collaborative work in Blaxall's laboratory showed that over-stimulating PAR1 in cardiac muscle cells leads to heart failure, while blocking it protects against the disease.

But, like most processes in the body, adrenaline doesn't drive PAR1 on its own; the team discovered it tags a middleman another protein, called MMP-13 which then prompts activation of PAR1 to wreak havoc in the heart.

"This research is very exciting because we've identified a completely new pathway activated by adrenaline that contributes to heart failure," said Blaxall, an associate professor at the Aab Cardiovascular Research Institute at the Medical Center.

Even more exciting, the team demonstrated that targeting either protein in the pathway removing PAR1 or inhibiting MMP-13 prevented cardiac dysfunction in mice, suggesting that drugs directed at either may hold promise for the treatment of heart disease.

"Our idea going forward is that in addition to blocking the effects of adrenaline, which is what beta blockers were designed to do, it may be wise to also inhibit MMP13, or PAR1, or both, to help patients with heart failure," noted Blaxall.

Potential drug candidates are already available. Inhibitors of MMP-13 are currently under evaluation, mostly as a potential treatment for rheumatoid arthritis and osteoarthritis, where MMP-13 has been shown to play a role in the development of each condition. Additionally, drugs that block PAR1 have been tested as antiplatelet agents drugs that stop blood clots from forming in large-scale clinical trials.

Blaxall says that in the future he plans to test drugs like these in animal models of heart failure.

This strategy is in line with work being done by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health, established in 2011 to address the gap between basic research findings and new treatments for patients. The center is encouraging researchers to focus on compounds that have already cleared key steps in the development process, including safety testing, as they work to develop new therapies.


'/>"/>
Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Witnessing, Experiencing Traumatic Events May Worsen Heart Disease
2. Risk of suicide and fatal heart attack immediately following a cancer diagnosis
3. Cancer Diagnosis May Raise Odds for Suicide, Heart Attack Death
4. In children born with severe heart defect, surgical management has little effect on neuro outcomes
5. Invasive heart test being dramatically overused, Stanford study shows
6. Heart failure patients with diabetes may benefit from higher glucose levels
7. Omega-3 Supplements No Help Against Repeat Heart Trouble: Review
8. EKG Heart Test May Predict Risk in Older Adults
9. Common Blood Pressure Drug Safe for Heart Failure: Study
10. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
11. SMART heart eases heart ache, targets cardiac patients emotional well-being
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... West Palm Beach, FL (PRWEB) , ... January 18, 2017 , ... ... April as a fund raiser for Smile Train, an international charity that provides free ... is a hobby of mine and in the past I have run to support ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... Dr. Farhan ... family, cosmetic and implants dentistry. His modern dental practice has two convenient office locations ... a 2017 Top Rated Dentist for the Alexandria area. This award confirms ...
(Date:1/18/2017)... ... 18, 2017 , ... During pregnancy, women are at an ... those dental problems can increase the risk of pregnancy complications. Unfortunately, according to ... to get the dental care they need. Agoura Hills dentist, Philip Shindler ...
(Date:1/17/2017)... ... January 17, 2017 , ... In the crowded Ath-leisure ... a stand-out company for several differences from other mainstream brands. , Firstly, ... this is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html . It allows them to ...
(Date:1/17/2017)... ... 2017 , ... Kevin Harrington (one of the original Sharks from mega-hit reality ... the topic of Beauty and Personal Care. , Everyone makes New ... to commit to these changes than beginning with personal care and beauty products? AsSeenOnTV.pro ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... -- Research and Markets has announced the addition of ... report to their offering. ... The global CINV drugs market to grow at a ... Thoracic Surgery Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. To ...
(Date:1/18/2017)... JAKARTA, Indonesia , Jan. 17, 2017  With an annual growth ranging from ... for success. CPhI SEA (Jakarta International Expo, March 22-24, 2017) serves the ... What,s new at CPhI SEA 2017? Investment Forum ... Distributors, network Richer conference content Enhanced business ... Reading ...
(Date:1/18/2017)... , Jan. 18, 2017   Seno Medical ... of diagnosing breast cancer through the development of an ... Steve Miller as SVP of Engineering. Mr. ... Realization at FUJIFILM SonoSite, with headquarters in ... majority of his 30-year career to the development of ...
Breaking Medicine Technology: