Navigation Links
Doubling down against diabetes

This press release is available in German.

A collaboration between scientists in Munich, Germany and Bloomington, USA may have overcome one of the major challenges drug makers have struggled with for years: Delivering powerful nuclear hormones to specific tissues, while keeping them away from others.

The teams led by physician Matthias Tschp (Helmholtz Zentrum Mnchen, and Technische Universitt Mnchen) and chemist Richard DiMarchi (Indiana University) used natural gut peptides targeting cell membrane receptors and engineered them to carry small steroids known to act at the cell nucleus. DiMarchi and Tschp hoped that such "turbo-charged" hormone hybrids would only deliver their steroid inside cells, where their specific peptide receptor was expressed at the surface.

Both teams had been working together for years to discover new ways to treat obesity and diabetes. They therefore started out with the gut hormone glucagon-like peptide-1, which is known to act at pancreas and brain cells to improve insulin secretion, blood glucose, and body weight. They engineered these peptides to reversibly bind the female sex steroid, estrogen, which is also known to confer powerful metabolic benefits at some of the same target cells. In the past, pharmacologists had been unable to utilize such benefits as high doses of systemic estrogen can also powerfully affect reproductive organs and increase cancer risk.

Using their GLP-1/estrogen-conjugates however, DiMarchi and Tschp found that they were able to multiply metabolic benefits in mice, without apparent side effects on estrogen-sensitive reproductive organs such as the uterus. They also found no impact of their "turbo-charged" gut peptides on growth of estrogen-sensitive tumors. Genetic studies at the same time however uncovered clear estrogen effects in pancreas and brain tissue of mice treated with the new combination drug candidate, indicating that the collaborating teams had indeed succeeded with targeted delivery of steroids.

"Our novel GLP-1/estrogen molecules seem to outperform more traditional therapeutics in mouse models of obesity and type 2 diabetes" says Brian Finan, scientist at the Helmholtz Zentrum Mnchen and first author of the study published online in the journal Nature Medicine. "What we are even more excited about" he adds "is the opportunity to use targeted steroid hormone for other diseases, where side effects had prevented therapeutic use in the past. "There is still a lot we don't know about the mechanistic details," cautions Matthias Tschp, director of the Helmholtz Institute for Diabetes and Obesity "but if they proof safe enough for clinical use, these molecules could offer transformative potential."


Contact: Tina Heun-Rattei
Technische Universitaet Muenchen

Related medicine news :

1. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
2. Scientists identify major source of cells defense against oxidative stress
3. Omega-3 Supplements No Help Against Repeat Heart Trouble: Review
4. Will women use microbicides to protect themselves against HIV?
5. Vitamin E in diet protects against many cancers
6. Lower-Dose Radioiodine Effective Against Thyroid Cancer
7. Study identifies possible protective blood factors against Type 2 diabetes
8. Stem Cell Study Shows Promising Results Against Heart Failure
9. Blood pressure drugs dont protect against colorectal cancer
10. CNIO scientists successfully test the first gene therapy against aging-associated decline
11. Vitamin D + TB vaccine: Allies in fight against bladder cancer?
Post Your Comments:
(Date:10/13/2015)... , ... October 13, 2015 , ... Local Gold’s Gym ... Gym International Conference on August 26. Berry, who owns and operates Gold's Gym ... the fastest growing Gold’s Gyms in the United States. A brand leader in global ...
(Date:10/13/2015)... ... October 13, 2015 , ... Breathing is one of the ... correctly. According to T’ai Chi (also spelled “Taiji”) and Qigong Grand-masters Steven Aung, ... concert with the 7,000 year old tradition they teach, can improve health, increase ...
(Date:10/13/2015)... ... ... With Fall weather approaching and holiday travel season upon us, is giving away ... to win! , How to Enter:, 1. Like on Facebook , 2. ... us on Instagram @thebeautyplace , 4. Share Facebook Contest Image With Friends , ...
(Date:10/13/2015)... DALLAS, Texas (PRWEB) , ... October 13, 2015 ... ... comprehensive treatment possible for children with autism, PediaPlex , a Southlake, Texas, ... value of ABA Therapy and educating military families about their options ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... sustainable and eco-friendly home furnishings and décor, today announced it closed on a ... investor. The funds will be used to support the Company’s continued rapid growth ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... MUNICH , October 13, 2015 ... --> World Thrombosis Day Interactive Infographic   ... World Thrombosis Day  to promote vital ... and signs and symptoms. Thrombosis is the formation ... (venous thrombosis) - resulting in venous thromboembolism (VTE) ...
(Date:10/13/2015)... PARK, Calif. , Oct. 13, 2015 /PRNewswire/ ... an agreement with the UK-based Cell Therapy Catapult ... for AST-VAC2, Asterias, allogeneic dendritic cell immunotherapy. Under ... and scale manufacturing processes for AST-VAC2 to support ... --> --> ...
(Date:10/12/2015)... -- Given the intricacy of the anatomy and ... an ophthalmic drug effectively to a specific ocular site. Several ... delivery. These include dilution of a drug by tears, clearance ... drug permeation issues with respect to the cornea, sclera and ... is lost due to the aforementioned barriers. --> ...
Breaking Medicine Technology: