Navigation Links
Doubling Time on Tamoxifen Cuts Odds for Breast Cancer's Return: Study
Date:6/2/2013

SUNDAY, June 2 (HealthDay News) -- When it comes to using the drug tamoxifen to prevent breast cancer's return, longer may be better for some patients, a new study finds.

Women combating estrogen-sensitive breast tumors fared better when treated with 10 years of tamoxifen compared to those given the current standard of five years, researchers found.

However, longer tamoxifen regimens were associated with a greater risk for side effects from the cancer-suppressing drug, such as night sweats, hot flashes, blood clots, strokes and a heightened risk for cancer of the lining of the uterus (endometrial cancer).

Still, the investigation found that 10 years of treatment gave patients better protection against the recurrence of estrogen receptor (ER)-positive breast cancers and/or death than did treatments offered for half as long.

Assessing the findings in conjunction with the results of another recently completed study called the ATLAS trial, the team concluded that the benefits of prolonged therapy still outweigh any risks.

The study was scheduled for presentation Sunday in Chicago at the annual meeting of the American Society of Clinical Oncology (ASCO).

Five years of tamoxifen "is already an excellent treatment but we thought that longer treatment might be even better because women with ER-positive breast cancer can have recurrences long after treatment is completed," study lead author Richard Gray, professor of medical statistics at the University of Oxford in the United Kingdom, said in an ASCO news release.

"Until now, though, there have been doubts whether continuing tamoxifen beyond five years is worthwhile," he added. "This study and its international counterpart ATLAS confirm that there is definitely a survival benefit from longer tamoxifen treatment and many doctors will likely recommend continuing tamoxifen for an extra five years."

The research was funded by Cancer Research UK and the UK Medical Research Council. Findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.

The study involved nearly 5,000 British breast cancer patients, all of whom had already completed a five-year regimen of tamoxifen by the time they entered the study at some point between 1991 and 2005.

In turn, half the women were randomly assigned to continue the medication for another five years, while half stopped the treatment altogether.

The result: no appreciable difference was found in death or breast cancer recurrence when assessing the impact of the sixth to ninth years of continued treatment.

However, when looking long-term -- at the 10th year and beyond -- the team found that the longer treatment option was having an impact. For example, breast cancer recurrence was lower among the 10-year group than the five-year group, at 16.7 percent versus 19.3 percent, respectively.

What's more, continuing treatment for double the usual period also reduced the overall risk of dying from breast cancer, the team noted.

"These results are therefore practice-changing for premenopausal women with hormone receptor-positive breast cancer and especially relevant for women who are at high risk of recurrence," Dr. Sylvia Adams, an ASCO spokesperson and breast cancer expert, said in the ASCO news release.

More information

There's more on estrogen and cancers at the U.S. National Cancer Institute.

-- Alan Mozes

SOURCE: American Society of Clinical Oncology, news release, June 2, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
2. Doubling down against diabetes
3. Doubling Up on Cold, Flu Remedies May Harm Liver
4. Doubling Tamiflu Dose for Severe Flu Doesnt Help: Study
5. Possible therapy for tamoxifen resistant breast cancer identified
6. New finding gives clues for overcoming tamoxifen-resistant breast cancer
7. 10 Years of Tamoxifen Better Than 5: Study
8. Tamoxifen trial should prompt breast cancer patients to reconsider treatment options
9. Ability to metabolize tamoxifen affects breast cancer outcomes, Mayo Clinic-led study confirms
10. Genes Linked to Effectiveness of Tamoxifen for Breast Cancer
11. Researchers identify new pathway, enhancing tamoxifen to tame aggressive breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Doubling Time on Tamoxifen Cuts Odds for Breast Cancer's Return: Study
(Date:2/12/2016)... ... February 12, 2016 , ... Donor Network West, the ... and Nevada, announced a partnership with San Ramon Regional Medical Center. Under the collaboration, ... facilities as a way to accommodate a more certain time frame for donor families ...
(Date:2/12/2016)... ... February 12, 2016 , ... J ... communities by continuing it’s commitment to act as Agents of Change in the ... closely with area homeless families to fulfill immediate needs and help them move ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... High-Cost Drug Categories: Strategies for Health Plans and PBMs,” an upcoming Feb. 24 ... maintain affordability and access in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis ...
(Date:2/12/2016)... , ... February 12, 2016 , ... A lot has ... 35 years. A president has access to health and wellness resources most Americans could ... world, no single individual has a schedule as frenetic as the U.S. President. ...
(Date:2/12/2016)... Middletown, N.J. (PRWEB) , ... February 12, 2016 ... ... Americans is creating explosive growth in the field of long term care. With ... heightened demand for well-trained healthcare professionals in administrative roles in long term care ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... February 12, 2016 ... vermerkt)   http://www.sedar.com ) und ... abrufbar.    --> http://www.sedar.com ... http://www.telestatherapeutics.com abrufbar.    --> ... heute seinen Konzernabschluss des zweiten Quartals ...
(Date:2/12/2016)... ALISO VIEJO , Kalifornien, 12. Februar 2016 ... es mit der Aufnahme von Patienten für eine ... Embolisation von Aneurysmen („WEB") speziell für die Behandlung ... Laurent Spelle , MD, Leiter der Neuroradiologie an ... , Frankreich, und Hauptprüfarzt der CLARYS-Studie hat den ...
(Date:2/12/2016)... , Feb. 12, 2016 On Thursday, ... Robotic Surgery at St. David,s North Austin Medical Center ... Vinci ® Xi ® Surgical System with ... 7000dV. Thiru Lakshman , M.D., colorectal surgeon ... total proctocolectomy utilizing Integrated Table Motion technology, which seamlessly ...
Breaking Medicine Technology: