Navigation Links
Double whammy: RNAi enhances lung cancer therapy
Date:3/20/2012

Non-small cell lung cancer (NSCLC), the most common form of lung cancer, is usually treated with surgery and chemotherapy. However, a small group of patients can also be helped by treatment with tyrosine kinase inhibitors (TKI). New research published in BioMed Central's open access journal BMC Medicine, shows that blocking production of epidermal growth factor receptor (EGFR) using RNAi, alongside TKI (or antibody therapy), could enhance the effect of TKI on NSCLC cell death, and slow cell growth.

There are 1.2 million new cases of lung cancer worldwide every year and about 75-85% of these are NSCLC. 10% of cases with NSCLC have a mutation in the gene responsible for making EGFR, and three quarters of these patients respond well to TKIs. However others are unresponsive, and, even for the people who responded at first, the cancer always ultimately becomes resistant to TKI therapy.

In an attempt to circumvent this problem researchers from Universitair Ziekenhuis Brussel, in Belgium, tested the effect of adding RNAi to standard TKI or antibody therapy in NSCLC cells. Proteins are made in the cell's cytoplasm, but DNA is stuck inside the nucleus. Consequently, in order to produce a protein, a cell must first copy the gene's DNA sequence, producing an intermediary molecule called RNA which is able to travel out of the nucleus to the cytoplasm. RNAi 'interferes' with the mechanism for producing proteins by blocking proper function of the intermediary RNA stage.

A team led by Prof De Grve and his co-worker, Gang Chen, found that the small interfering RNA (siRNA) molecule they designed was able to inhibit EGF protein production in all the NSCLC cell lines tested. It was also able to slow down cell growth and increase cell death (apoptosis) in all the cell lines although some responded better than others. When they tested siRNA alongside TKI and or monoclonal antibodies they discovered that the siRNA had an additional positive ef
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. U.S. Deaths From Gastro Infections Doubled Over 8 Years: CDC
2. New drug, Vemurafenib, doubles survival of metastatic melanoma patients
3. New street drug bath salts packs double punch
4. New combo of chemo and well-known malaria drug delivers double punch to tumors
5. Pot Use Could Double Risk of Car Crash, Research Shows
6. Rate of physician referrals nearly doubled
7. Targeting EETs to treat cardiovascular disease may prove a double-edged sword
8. Scientists may be able to double efficacy of radiation therapy
9. Asthma rates double for WTC first responders
10. Use of opioid painkillers for abdominal pain has more than doubled
11. STD Complication May Double Infertility Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... The improved access to antiretroviral drugs and treatments ... has led to the decline in the rate of ... AIDS globally. However, despite the fact that HIV infection ... affected by the virus is on the rise. With ... organisations and stakeholders, by 2015, significant investments are expected ...
(Date:8/22/2014)... Orange, NJ. August 22, 2014. A new ... that persons with multiple sclerosis (MS) may be ... rehabilitation. The study was epublished ahead of print ... Goverover, Helen Genova, Hali Griswold, Nancy D. Chiaravalloti ... in persons with multiple sclerosis doi: 10.3233/NRE-141113). Self-awareness ...
(Date:8/22/2014)... to open blockages in the kidney arteries may ... modern clinical trials, according to new recommendations for ... Cardiovascular Interventions today by the Society for ... Case Medical Center,s Sahil Parikh, MD, Director, Interventional ... Western Reserve University School of Medicine was the ...
(Date:8/22/2014)... Home Care Assistance of Centennial , North ... proud to announce the next installment in its renowned ... Dr. Suzanne Steinbaum, attending cardiologist and Director of Women’s ... City, National Spokesperson for the American Heart Association’s Go ... issues surrounding women and heart disease, what heart disease ...
(Date:8/22/2014)... 22, 2014 (HealthDay News) -- Many children get anxious ... but there are a number of ways that parents ... expert suggests. The first step is to explain ... help protect their health, said Rita John, director of ... University School of Nursing in New York City. ...
Breaking Medicine News(10 mins):Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 2Health News:Worldwide HIV Infection Drug Market Examined in New Kuick Research Report Published at MarketPublishers.com 3Health News:Kessler Foundation study of self-awareness in MS has implications for rehabilitation 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 2Health News:UH Case Medical Center's Dr. Parikh authors SCAI paper on renal artery stenosis treatment 3Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3Health News:Simple Steps Make Shots Less Scary for Kids, Nurse Says 2
... Strength and Conditioning Coach Greg Brittenham Rally Students to Get ... Fit Grant NEW YORK, March 19 New York Knicks ... Brittenham are rallying New York City teens to get teenagers ... campaign called Get Fit By Finals . The ...
... Lawsuit Alleges that Drywall Emits Toxins Harmful to Humans ... Jason and Melissa Harrell recently filed a class ... of themselves and other homeowners who purchased defective homes. ... new home, and those of their neighbors, emits destructive ...
... Va., March 19 Together Rx Access(R), a prescription ... pharmaceutical companies, announced today that it has expanded the ... individuals and families save on the medicines they need ... the new income levels, nearly 90 percent of uninsured ...
... of Anesthesiologists, Action vs. RhetoricCORONA DEL MAR, Calif., March ... very fair odds. Yet, that,s exactly what the foremost ... set the stage for last week when he responded ... press release in which they claimed to be in ...
... by the American Society for Aesthetic Plastic Surgery, the number of cosmetic ... this sharp decline nationally, the flow of patients at the Center for ... , ... Annandale VA (Vocus) March 19, 2009 -- The ASAPS data ...
... been waiting on for the past four years to prove the deposition ... ... March 19, 2009 -- Most ENT,s and physicians have prescribed Sinus ... a clinical study done on the amount of medication deposited and penetrated ...
Cached Medicine News:Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Democracy Prep Charter School 2Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Democracy Prep Charter School 3Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Democracy Prep Charter School 4Health News:Got Milk?(R) and the NBA Showcase New National Teen Health and Fitness Initiative at Democracy Prep Charter School 5Health News:Class Action Filed Against South Florida Developer and Supplier of Defective Chinese Drywall 2Health News:Class Action Filed Against South Florida Developer and Supplier of Defective Chinese Drywall 3Health News:Together Rx Access(R) Program Expands Eligibility Criteria, Responds to Challenging Economic Times 2Health News:Together Rx Access(R) Program Expands Eligibility Criteria, Responds to Challenging Economic Times 3Health News:Together Rx Access(R) Program Expands Eligibility Criteria, Responds to Challenging Economic Times 4Health News:Dr. Barry Friedberg comments on David vs. Goliath: Who's Really in the Pursuit of Patient Safety & Satisfaction? 2Health News:The Center for Plastic Surgery in Washington, DC Survives the Economy Despite Nationwide Data Reported by ASAPS 2Health News:New Clinical Study News for Treatment of Sinusitis - Sinus Infection and Allergy Suffers Now Have a New Effective Form of Relief through Sinus Dynamics 2Health News:New Clinical Study News for Treatment of Sinusitis - Sinus Infection and Allergy Suffers Now Have a New Effective Form of Relief through Sinus Dynamics 3Health News:New Clinical Study News for Treatment of Sinusitis - Sinus Infection and Allergy Suffers Now Have a New Effective Form of Relief through Sinus Dynamics 4
(Date:8/21/2014)... The spinal column is one of the most ... to and from the brain through the column control many ... or ailment here can be life altering, and leave the ... over their body. Though back injury and disease can have ... more options available to make things better than ever before. ...
(Date:8/21/2014)... - The Canadian Epilepsy Alliance (CEA) is thrilled to announce ... children about the most common neurological disorder in ... comic series tells a fictional story based on the experiences ... with epilepsy. "Despite the fact that epilepsy ... misinformation and lack of awareness out there," says Gail ...
(Date:8/21/2014)... HAMBURG, Germany , Aug. 21, 2014  IBM ... with Deutsches Elektronen-Synchrotron ( DESY ), a leading national ... speed up management and storage of massive volumes of ... architecture based on IBM software defined technology can ... at peak performance and help scientists worldwide gain faster ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
Immersion Oil, 150 cs...
Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
Immersion oil for microscopy...
... Immersion Oil Type DF is the ... for fluorescence microscopy and it also ... Oil Type FF has virtually zero ... worldwide immersion oil of choice when ...
Medicine Products: