Navigation Links
Double threat: Deadly lung disease also linked to heart attacks
Date:12/4/2008

Patients with idiopathic pulmonary fibrosis (IPF) are three times as likely to experience severe coronary eventsincluding heart attacksthan people without the disease, according to a recent study that analyzed the risk of cardiovascular disease in nearly 1,000 patients with IPF and more than 3,500 matched controls.

"If you look at them over time, people with IPF have roughly a three-fold increased risk of acute coronary syndrome, which is a greater increase than you get from smoking," said Richard B. Hubbard, M.D., British Lung Foundation professor of epidemiology at the University of Nottingham and lead author of the study.

The study was published in the second issue for December of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Dr. Hubbard and colleagues analyzed data from the computerized records of the UK's Health Improvement Network for 920 patients with idiopathic pulmonary fibrosis and 3,593 control subjects without IPF for diagnoses of coronary events and disease incidence.

In addition to having a markedly increased risk of heart problems, patients with IPF were 23 percent more likely to have angina, had a 60 percent higher risk of stroke, and a three-fold increased risk of deep vein thrombosis, according to Dr. Hubbard.

Notably, those with IPF were more than twice as likely as control subjects to have been prescribed amiodarone, a medication used for irregular heartbeats that has also been implicated as a cause of fibrotic lung disease.

This research could have serious implications for the 60,000 people with IPF who currently live in the United States and the 21,000 people who receive this diagnosis for the first time each year. Median survival from the time of diagnosis is about three years, and there are currently no treatments that have been shown to increase survival.

Unfortunately, medical knowledge about IPF is limited. "We know that genetic factors play some role in IPF because it clusters in families in about 10 percent of cases and in a similar number of people there is evidence that environmental factors, such as exposure to metal dust at work and cigarette smoking may have a role," said Dr. Hubbard. "[But] studies from the U.S.A. and the U.K. suggest that IPF is becoming more common, and the reasons for this are unclear."

"Future investigations are required to better understand the relationship between IPF and systemic vascular disease as well as the mechanisms shared by the two syndromes," wrote David Zisman, M.D., and Steven Kawut, M.D., in an editorial in the same issue of the journal. "[I]f a causal association were confirmed the presence of IPF itself could constitute a sufficiently potent risk factor for coronary artery disease such that more aggressive goals in risk factor modification would be warranted."

Such a mysterious disease as IPF raises a host of questions, but the most pressing ones are about how to improve and extend the lives of its victims.

"People with IPF have got a very bad outlook, and we may need to focus on other aspects of their health. The current guidelines are focused on palliative care so that people get oxygen and their symptoms treated, but maybe patients should go on heart prevention treatments right away," Dr. Hubbard said. "Future strategies could include a trial of anti-coagulant therapy in IPF patients," he added.

John Heffner, M.D., past president of the ATS, commented that this study introduces a change in our thinking of IPF. "As with other chronic, progressive respiratory disorders, the lungs in IPF may be the bellwether of other more systemic pathogenic events. What is first expressed in the lung becomes manifest later in other organ systems. This perspective will both realign research efforts and also direct more comprehensive healthcare to patients diagnosed with early IPF."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Cellular senescence a double-edged sword
2. Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
3. Blue Cross Launches Statewide Healthy Eating Campaign to Double Number of Minnesotans Eating Fruits, Veggies
4. Pregnancy diabetes doubles the risk of language delay in children
5. Tweens and Teens Double Use of Diabetes Drugs
6. Election-Eve MedPage Today(R) Poll Gives Obama Double-Digit Lead Among Clinicians
7. Tweens and teens double use of diabetes drugs
8. Study reports Double Balloon Endoscopy useful for diagnosis and treatment of obscure GI bleeding
9. Rate of Diabetes Cases Doubles in 10 Years: CDC
10. Cost of Diabetes Care Has Doubled
11. Sharps Compliance Corp. Reports Net Income More Than Doubles on 26% Increase in Revenue in the First Quarter of Fiscal 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
Breaking Medicine Technology: