Navigation Links
Double threat: Deadly lung disease also linked to heart attacks
Date:12/4/2008

Patients with idiopathic pulmonary fibrosis (IPF) are three times as likely to experience severe coronary eventsincluding heart attacksthan people without the disease, according to a recent study that analyzed the risk of cardiovascular disease in nearly 1,000 patients with IPF and more than 3,500 matched controls.

"If you look at them over time, people with IPF have roughly a three-fold increased risk of acute coronary syndrome, which is a greater increase than you get from smoking," said Richard B. Hubbard, M.D., British Lung Foundation professor of epidemiology at the University of Nottingham and lead author of the study.

The study was published in the second issue for December of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Dr. Hubbard and colleagues analyzed data from the computerized records of the UK's Health Improvement Network for 920 patients with idiopathic pulmonary fibrosis and 3,593 control subjects without IPF for diagnoses of coronary events and disease incidence.

In addition to having a markedly increased risk of heart problems, patients with IPF were 23 percent more likely to have angina, had a 60 percent higher risk of stroke, and a three-fold increased risk of deep vein thrombosis, according to Dr. Hubbard.

Notably, those with IPF were more than twice as likely as control subjects to have been prescribed amiodarone, a medication used for irregular heartbeats that has also been implicated as a cause of fibrotic lung disease.

This research could have serious implications for the 60,000 people with IPF who currently live in the United States and the 21,000 people who receive this diagnosis for the first time each year. Median survival from the time of diagnosis is about three years, and there are currently no treatments that have been shown to increase survival.

Unfortunately, medical knowledge about IPF is limited. "We know that genetic factors play some role in IPF because it clusters in families in about 10 percent of cases and in a similar number of people there is evidence that environmental factors, such as exposure to metal dust at work and cigarette smoking may have a role," said Dr. Hubbard. "[But] studies from the U.S.A. and the U.K. suggest that IPF is becoming more common, and the reasons for this are unclear."

"Future investigations are required to better understand the relationship between IPF and systemic vascular disease as well as the mechanisms shared by the two syndromes," wrote David Zisman, M.D., and Steven Kawut, M.D., in an editorial in the same issue of the journal. "[I]f a causal association were confirmed the presence of IPF itself could constitute a sufficiently potent risk factor for coronary artery disease such that more aggressive goals in risk factor modification would be warranted."

Such a mysterious disease as IPF raises a host of questions, but the most pressing ones are about how to improve and extend the lives of its victims.

"People with IPF have got a very bad outlook, and we may need to focus on other aspects of their health. The current guidelines are focused on palliative care so that people get oxygen and their symptoms treated, but maybe patients should go on heart prevention treatments right away," Dr. Hubbard said. "Future strategies could include a trial of anti-coagulant therapy in IPF patients," he added.

John Heffner, M.D., past president of the ATS, commented that this study introduces a change in our thinking of IPF. "As with other chronic, progressive respiratory disorders, the lungs in IPF may be the bellwether of other more systemic pathogenic events. What is first expressed in the lung becomes manifest later in other organ systems. This perspective will both realign research efforts and also direct more comprehensive healthcare to patients diagnosed with early IPF."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Cellular senescence a double-edged sword
2. Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
3. Blue Cross Launches Statewide Healthy Eating Campaign to Double Number of Minnesotans Eating Fruits, Veggies
4. Pregnancy diabetes doubles the risk of language delay in children
5. Tweens and Teens Double Use of Diabetes Drugs
6. Election-Eve MedPage Today(R) Poll Gives Obama Double-Digit Lead Among Clinicians
7. Tweens and teens double use of diabetes drugs
8. Study reports Double Balloon Endoscopy useful for diagnosis and treatment of obscure GI bleeding
9. Rate of Diabetes Cases Doubles in 10 Years: CDC
10. Cost of Diabetes Care Has Doubled
11. Sharps Compliance Corp. Reports Net Income More Than Doubles on 26% Increase in Revenue in the First Quarter of Fiscal 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream that really works. ... be incorporated into the post-surgical treatment plans of a variety of other procedures including, ... is very effective for bruising and causes a rapid resolution of bruising and inflammatory ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Seema Daulat, a native Texan and University ... Lamar location as of July 13, 2016. , Dr. Daulat earned her Doctorate of ... she regularly volunteered at the Agape Clinic serving Dallas’ underprivileged community. , Following medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
Breaking Medicine Technology: