Navigation Links
Double-pronged attack could treat common children's cancer
Date:11/1/2013

habdomyosarcoma samples from patients, and that 43% of these also showed activation of the MAP Kinase pathway. In experiments on rhabdomyosarcoma cells to block either pathway alone, they saw compensatory signalling through the alternative pathway, suggesting that inhibiting both pathways is an essential approach to treatment, irrespective of whether MAP kinase signalling was initially activated.

The researchers tested rhabdomyosarcomas with drugs known to be effective against the PI3 Kinase and MAP Kinase pathways. When they tried the drugs AZD8055 and AZD6244 separately they saw reduced cell growth and a decrease in levels of markers showing the activity of the signalling pathways. However, compensatory activity was clearly evident.

But when they combined the two drugs they found a synergistic effect, with cell growth reduced to a greater extent than with either treatment alone. They saw similar synergistic results when AZD8055 and AZD6244 were used together in mice with rhabdomyosarcoma tumours, with tumour marker levels reduced to less than 30% of those in controls.

Co-author Dr Janet Shipley, Team Leader in Sarcoma Molecular Pathology at The Institute of Cancer Research, said:

"Rhabdomyosarcoma is the main type of sarcoma to affect children and little improvement has been made recently using conventional treatments like chemotherapy and radiotherapy - survival rates for some patients with this disease remain bleak. More effective targeted treatment is desperately needed. Our study shows that treating with one or other of these two drugs is not a good strategy but that combining them is a very promising option."

Co-author Dr Jane Renshaw, Senior Scientific Officer at The Institute of Cancer Research, said:

"We found that while most rhabdomyosarcoma tumours seem to have active PI3K signalling, inhibiting this pathway alone isn't enough to be an effective treatment. Cross-talk between the PI3 Kinase and MAP Kinase pa
'/>"/>

Contact: Lauren King
lauren.king@icr.ac.uk
020-715-35380
Institute of Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Heart Attack Season Survival Tips
2. New Paper Argues Attacks on Family Planning Funds Limit Affordable Care Act's Effectiveness
3. Practical Self-Defense Teaching Manual, “One Strong Move,” Uses Cartoon-Illustrations To Engage Teens And Adults In Learning How To Spot Danger And Stop An Attack
4. Study shows no increased risk for heart attacks among HIV-positive patients with high CD4 cell count
5. Panic Away Review Reveals Natural Ways to Stop Panic Attacks
6. Flu shot halves risk of heart attack or stroke in people with history of heart attack, study finds
7. Flu shot halves risk of heart attack or stroke in people with history of heart attack, study finds
8. Heart Attack Reinforces Farmers’ Market Manager’s Mission and Alliance with HMHP
9. Asthma attack prevention proposal awarded NIH New Innovator grant
10. Medicare expenses for patients with heart attacks increase between 1998 and 2008
11. Brown & Toland Physicians Honors Heart Attack Survivor Jeffrey Houck with Lifestyle Change Award During Heart Walk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... BC (PRWEB) , ... June 30, 2015 , ... When ... might be that they feel the associated costs will be too high. However, there ... have the volunteer abroad experience at minimal cost. One such volunteer named ...
(Date:6/30/2015)... ... June 30, 2015 , ... Some may define success as the sum of ... New York State Athletic Trainers’ Association (NYSATA) and its members continue to be acknowledged ... awards, and a number of members also received honors at the national level. ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... scientists and analysts who are currently attending an accredited American educational institution through ... has provided new insight into healthcare, the environment, political campaigns, and a variety ...
(Date:6/30/2015)... ... June 30, 2015 , ... Curly Hair Solutions™ is honoured to attend Cosmoprof ... the US, featuring products from all over the world. For the first time ever, ... line of hair styling products focused entirely on meeting the needs of all ...
(Date:6/29/2015)... ... June 30, 2015 , ... Aespala Medspa and Plastic Surgery ... surgeon Dr. David Dreyfuss. , Dr. Dreyfuss received his medical degree from Emory ... Chicago, followed by a Plastic Surgery Fellowship at the University of Chicago. He has ...
Breaking Medicine News(10 mins):Health News:Volunteers Transform Themselves and Their Resumes with Medical Volunteer Placements Abroad 2Health News:Volunteers Transform Themselves and Their Resumes with Medical Volunteer Placements Abroad 3Health News:NYSATA and Members Recognized with National Awards 2Health News:NYSATA and Members Recognized with National Awards 3Health News:Izenda Offers Embedded BI and Analytics Scholarship 2Health News:Izenda Offers Embedded BI and Analytics Scholarship 3Health News:Curly Hair Solutions™ Showcases Entire Curl Keeper™ Collection at Cosmoprof Las Vegas July 12 - 14 2Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 2Health News:Aespala Medspa and Plastic Surgery Welcomes New Plastic Surgeon to Oak Brook, IL Office 3
... research finding, two thirds of the young population who suffer from ... //This research was conducted by beat, an association for easting disorders ... six hundred people who took part in this study, 550 people ... in the age group of 14-25 are at a greater risk. ...
... expert Dr.David Nabarro, Senior U.N. Coordinator for Avian and Human Influenza ... ,Speaking from Indonesia where he is attending a bird flu conference, ... up to May, as this is the time when migratory birds ... turkey farm at Suffolk, UK was witness to the death of ...
... surprisingly few doctors are ‘logged’ in. , For years ... and result in doctor- patient e-mailing, but oddly ... Wall Street Journal Online shows only 8 percent of adults ... another research showed that though 25 percent of doctors profess ...
... the national clinical director for health care, Dr. David ... to expand their services. This will include performing small ... and other minor problems. , According to Thome, ... increase efficiency as well as cut costs. ,The ...
... vision changes with age, but you hadn’t anticipated vision problems ... are common with aging. The skin around your eyes is ... the muscles weaken and fat tends to gather over and ... affect vision and produce a tired appearance -- no matter ...
... the end of a woman’s reproductive years, usually occurs ... some women experience //early menopause. Early menopause can be ... health problems, including osteoporosis and cardiovascular disease. ... describes types of early menopause. ,Premature ...
Cached Medicine News:Health News:Doctors –you’ve Got Ma 2
(Date:6/29/2015)... 29, 2015  New guidelines released today by ... give hope for better outcomes to the hundreds ... ischemic stroke each year. Stryker,s Trevo ® ... in the clinical trials that provided data for ... strongly recommend endovascular therapy with stent retrievers for ...
(Date:6/29/2015)... PAUL, Minn. , June 29, 2015 ... manufacturer of devices that use neuroblocking technology to treat ... that it has commenced an underwritten public offering of ... common stock, Series A warrants to purchase common stock ... whose purchase of units in the offering would result ...
(Date:6/29/2015)... Sciences, Inc. (NASDAQ: ALIM ) (Alimera), a pharmaceutical ... of prescription ophthalmic pharmaceuticals, today announced that Rick ... will present at the 2015 Cantor Fitzgerald Inaugural Healthcare ... at Le Parker Meridien Hotel in New ... webcast live and will be available for access, along ...
Breaking Medicine Technology:New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 2New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 3EnteroMedics Inc. Announces Proposed Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Proposed Public Offering of Common Stock and Warrants 3
... , ATLANTA , Feb. 8 ... an Atlanta -based, biopharmaceutical company developing human vaccines for ... agents, today provided an update on its vaccine trials progress. ... rate, 60,000 new infections annually, and that,s just in ...
... , PORTLAND, Ore. , Feb. 8 ... use of localized content by sales teams. Together, the companies ... translated content to reach the hands of global sales professionals ... sales cycle. This combination gives the sales person the right ...
Cached Medicine Technology:GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 2GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 3GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 4GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 5GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 6Prolifiq and viaLanguage Announce Partnership: Accelerate the Use of Localized Content by Sales Teams 2Prolifiq and viaLanguage Announce Partnership: Accelerate the Use of Localized Content by Sales Teams 3
Inquire...
... Tips offer a safe alternative to using ... for applications such as PCR(a), pipetting radioactive ... Tips are excellent for tissue culture, gel ... Tips prevent aerosol contaminants and liquids from ...
... Eliminate aerosol contamination, ... reactions in PCR. Hydrophobic, ... Only air can pass ... tips, in contrast to ...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
Medicine Products: