Navigation Links
Double binding sites on tumor target may provide future combination therapy
Date:4/8/2008

PHILADELPHIA - Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer.

An increasing number of therapies targeting tumors that have proteins called epidermal growth factor receptors (EGFR) sitting on their surface are already being used in the clinic or are in late stages of development. For example, Herceptin is an established treatment for certain types of breast cancer and Erbitux and Vectibix are in use for other types of cancer. An additional drug called matuzumab is in phase II clinical trials.

Three years ago, Kate Ferguson, PhD, Assistant Professor of Physiology, and colleagues determined the precise molecular details of how Erbitux, a colorectal and head and neck cancer drug, binds to its target on cancer cells. EGFR drugs halt cell proliferation by blocking EGFRs molecular doorway, keeping hormones from binding and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the extracellular component of the cancer cells receptors.

As is characteristic of many epithelial cancers - such as cancers of the colon, head and neck, breast, ovary, lung, and pancreas - the surface of cancer cells possess abnormally high levels of EGFR. In a cancer cell, an extracellular hormone binds to the outer piece of EGFR, and causes the inside part to kick off a series of reactions that signal the cancerous cell to replicate and divide.

In the present study, published in Cancer Cell, Ferguson and Merck colleagues found again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. Their binding does not overlap, and they can bind to EGFR at the same time.

These findings imply that a combination therapy usin
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gum Disease, HPV a Double Whammy
2. Uroplasty Plans to Double Sales Force During Fiscal 2009
3. Diabetics Face Doubled Risk of Heart Attack
4. Ford Launches Warriors in Pink Mustang for 09, Doubles Contributions To Race For The Cure
5. Diversified Clinical Services Doubles Field Management
6. Rate of escalator injuries to older adults has doubled
7. The Makers of Conquer HA(TM) Launch All-Natural Double Strength Anti- Inflammatory Formula
8. Amilpar Revenues Increase by 32% and EBITDA Doubles in 2007
9. Led by Cardiovascular Applications, Double Digit Growth Expected for Catheter Sales
10. Double Lung Transplant Better for Younger COPD Patients
11. Age-Related Macular Degeneration Doubles Heart Attack and Stroke Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... The KIND LED K5 grow lights utilize a ... These large yields are due to the KIND LED 3 amd ... K5 grow lights use a proprietary 12 band spectrum that runs ... circuit boards that are the backbone of the KIND LED lighting ... immense. The KIND LED K5 grow lights use about half of ...
(Date:3/31/2015)... Effective April, 1 2015, Plano ... practice with North Texas Obstetrics & Gynecology Associates. This ... approach to women’s healthcare. With 17 years of experience ... this move will not interrupt the care of existing ... his practice to new patients. , Recognized as a ...
(Date:3/31/2015)... (PRWEB) March 31, 2015 Homeowners and ... Drivable Grass in action and installed in ... finished installation of a display plot of Drivable Grass ... , Drivable Grass is a permeable concrete pavement system ... to asphalt and concrete pavement, Drivable Grass qualifies for ...
(Date:3/31/2015)... A new study by Health eCareers found that nearly one-third ... their greatest staffing concern this year and say hiring the ... you have them, you need to keep them. The findings ... recruiting blog series , which profiles the results of the ... high numbers and results in high costs in the industry. ...
(Date:3/31/2015)... Telemedicine technology is bringing the ... Barnes-Jewish Hospital to patients at Memorial Hospital of ... (SIH) system. , “Previously, when an expectant mother ... consultation, she had to travel two hours to ... talk with a Barnes-Jewish specialist,” says Ellyn Rosenblum, ...
Breaking Medicine News(10 mins):Health News:LED SuperNova Grow Box by SuperCloset Now Available with the KIND LED K5 Series 2Health News:Plano OBGYN Dennis Eisenberg, MD Joins North Texas Obstetrics & Gynecology Associates in Plano, Texas 2Health News:Super-Sod Recently Completed a Drivable Grass Permeable Paver Demo at their Jacksonville Store 2Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 2Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 3Health News:New Survey Finds Staff Turnover Top Concern for Healthcare Recruiters in 2015 4Health News:Access to Maternal-fetal Experts Expands into Rural Communities 2Health News:Access to Maternal-fetal Experts Expands into Rural Communities 3
... Blood pressure problems fall 75 percent after procedure, study ... weight-loss surgery before having a baby greatly lowers the ... during pregnancy, a new study reports. , Obese ... risks for blood pressure disorders such as preeclampsia during ...
... ... OxySure has been named as a finalist in the Health category for its ... Awards recognize new companies that will have a significant impact on the environment, ... used to raise funds to support business incubation programs for technology-based entrepreneurs. ...
... over finances, study finds , TUESDAY, April 13 (HealthDay News) -- ... medical care are more likely to postpone seeking emergency care for ... these factors lead to delays in seeking care of six hours ... findings. , The study, reported in the April 14 issue of ...
... , ... Makes Gift to Endow Presidential Chair , ... La Jolla, Calif. (Vocus) April 13, 2010 -- Sanford-Burnham ... President of the Institute. In this role, she will oversee Sanford-Burnham,s day-to-day operations. Prior ...
... available in French . , Montreal, ... selected by Montral,s International Laboratory for Brain, Music and ... signal processing devices (DSP) to investigate experience-dependent brain plasticity ... change a person,s sound perception, in real time, and ...
... ... of every 6 men in the United States (1 in 3 in the African American ... cancer by registering for Little Red Door,s Unite 2 Fight Race Against Prostate Cancer. ... Indianapolis, IN (PRWEB) April 13, ...
Cached Medicine News:Health News:Weight-Loss Surgery May Ease Childbirth Risks 2Health News:OxySure Systems, Inc. Named Tech Fort Worth IMPACT Awards Finalist 2Health News:OxySure Systems, Inc. Named Tech Fort Worth IMPACT Awards Finalist 3Health News:Money Worries Delay Heart Attack Treatment 2Health News:Money Worries Delay Heart Attack Treatment 3Health News:Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute 2Health News:Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute 3Health News:Dr. Kristiina Vuori Promoted to President of Sanford-Burnham Medical Research Institute 4Health News:New research tools for BRAMS via Sonomax Technologies 2Health News:Registration Now Open for Little Red Door's Unite 2 Fight Race Against Prostate Cancer Saturday, July 10, 2010 2
(Date:3/30/2015)... -- Building on the momentum of the first quarter of 2015, ... systems, has announced aggressive plans to expand its Medicaid Home ... business models. The first quarter addition of new ... and Louisiana is a ... statewide coverage in each state. This brings the total to ...
(Date:3/30/2015)... 30, 2015 Perrigo Company plc (NYSE: ... Affordable Healthcare Products®," today announced that it has completed ... in a cash and equity transaction valued at approximately ... in debt. Sellers are Marc Coucke , Waterland ...   "The combination of Perrigo ...
(Date:3/30/2015)... , March 30, 2015  Caris Life Sciences® ... drugs targeting specific pathways may have potentially significant benefit ... The study results were highlighted today in an oral ... Gynecologic Oncology (SGO) 2015 Annual Meeting on Women,s Cancer ... This study is one of four presented at the ...
Breaking Medicine Technology:MedScope's Aggressive 2015 Expansion Focuses on Medicaid Waiver and Managed Care Organizations 2Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 2Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 3Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 4Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 5Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 2Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 3Caris Life Sciences' Multiplatform Tumor Profiling Enhances Understanding of Molecular Drivers and Treatment Selection in Uterine Carcinomas 4
Lytec Medical 2004 practice management software is designed to help you more effectively manage your accounts receivable as well as track authorizations and inventory. Lytec Medical XE provides outst...
PremierEdge™ Stab Knives - 30°....
DCR Set, Angled....
... The Leica CM3050 S ... comfort with excellent safety standards ... cryosectioning applications. The Leica CM3050 ... choice for all cryosectioning research ...
Medicine Products: