Navigation Links
Double binding sites on tumor target may provide future combination therapy
Date:4/8/2008

PHILADELPHIA - Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer.

An increasing number of therapies targeting tumors that have proteins called epidermal growth factor receptors (EGFR) sitting on their surface are already being used in the clinic or are in late stages of development. For example, Herceptin is an established treatment for certain types of breast cancer and Erbitux and Vectibix are in use for other types of cancer. An additional drug called matuzumab is in phase II clinical trials.

Three years ago, Kate Ferguson, PhD, Assistant Professor of Physiology, and colleagues determined the precise molecular details of how Erbitux, a colorectal and head and neck cancer drug, binds to its target on cancer cells. EGFR drugs halt cell proliferation by blocking EGFRs molecular doorway, keeping hormones from binding and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the extracellular component of the cancer cells receptors.

As is characteristic of many epithelial cancers - such as cancers of the colon, head and neck, breast, ovary, lung, and pancreas - the surface of cancer cells possess abnormally high levels of EGFR. In a cancer cell, an extracellular hormone binds to the outer piece of EGFR, and causes the inside part to kick off a series of reactions that signal the cancerous cell to replicate and divide.

In the present study, published in Cancer Cell, Ferguson and Merck colleagues found again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. Their binding does not overlap, and they can bind to EGFR at the same time.

These findings imply that a combination therapy using both types of EGFR drugs could be developed and tested, says Ferguson. This has important implications for the clinical use of matuzumab and for developing new therapies that target EGFR.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Gum Disease, HPV a Double Whammy
2. Uroplasty Plans to Double Sales Force During Fiscal 2009
3. Diabetics Face Doubled Risk of Heart Attack
4. Ford Launches Warriors in Pink Mustang for 09, Doubles Contributions To Race For The Cure
5. Diversified Clinical Services Doubles Field Management
6. Rate of escalator injuries to older adults has doubled
7. The Makers of Conquer HA(TM) Launch All-Natural Double Strength Anti- Inflammatory Formula
8. Amilpar Revenues Increase by 32% and EBITDA Doubles in 2007
9. Led by Cardiovascular Applications, Double Digit Growth Expected for Catheter Sales
10. Double Lung Transplant Better for Younger COPD Patients
11. Age-Related Macular Degeneration Doubles Heart Attack and Stroke Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 08, 2016 , ... Brenntag Specialties, Inc.(BSI) , is ... & Beverage and Dietary Supplement market segments across the western ... geographies east of the Rocky Mountains since 2012. Consistent performance in business ...
(Date:2/8/2016)... ... ... The Valentine’s Season is famous for gift giving with flowers, chocolates and other tokens of ... This year, for more than 5.6 million Americans suffering with Alzheimer’s, those store bought gifts ... them of the lives they’ve led and the people they’ve touched. , That’s ...
(Date:2/8/2016)... ... February 08, 2016 , ... If you are feeling ... handle, you are not alone. According to the Center for Disease Control and Prevention ... type 2 diabetes and certain types of cancer, some of the leading causes of ...
(Date:2/8/2016)... ... 2016 , ... The Bell Agency, a full service insurance ... their ongoing community enrichment program. The current campaign fundraises for Angels & Doves, ... being accepted at: http://www.angelsanddoves.com/donate.html . , Angels & Doves was founded in ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... networking and relationship-marketing firm, announced today that nominations will be accepted February ... (ISE®) West Awards. , Awards include the Information Security Executive® of ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... GLENWOOD, Ill., Feb. 9, 2016  Landauer, Inc. (NYSE: ... environmental radiation measurement and monitoring, outsourced medical physics services ... results for its fiscal 2016 first quarter ended December ... --> Fiscal 2016 First Quarter Highlights , ... the first quarter of 2015 , Domestic Radiation Measurement ...
(Date:2/9/2016)...  Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) today ... and full year financial results on Tuesday, February 23, ... management will host a live audio webcast immediately following ... discuss fourth quarter and full year 2015 financial results ... for 2016 financial results. www.jazzpharmaceuticals.com .  Please ...
(Date:2/9/2016)... Amarantus BioScience Holdings, Inc. ... for Regenerative Medicine, Neurology and Orphan Diseases, today announced ... Source Capital Group,s 2016 Disruptive Growth & Healthcare Conference ... New York City . The Company,s presentation ... 12:30 pm by Gerald E. Commissiong , President ...
Breaking Medicine Technology: