Navigation Links
Double assault on tough types of leukemias
Date:9/20/2012

p>

Crispino expects alisertib will be a more gentle cancer drug without the ravaging side effects of conventional chemotherapies. This is because the drug specifically targets a key enzyme, avoids healthy cells in the bone marrow and blood, and will probably be more effective at lower doses than drugs tested in previous studies.

"This study has given us a scientific rationale to take this drug to an early phase clinical trial in this very challenging form of leukemia," said Jessica Altman, M.D., assistant professor in hematology/oncology at Feinberg and an oncologist at Northwestern Memorial Hospital. Altman also is a member of the Lurie Cancer Center. Together with other leukemia specialists, she is designing a multi-center clinical trial planned to open in 2013.

Investigators also identified another attack plan for other types of leukemias. Sifting through 9,000 chemical compounds during the study, they found that dimethylfasudil boosted the number of mature bone marrow cells and shot down malignant ones.

Dimethylfasudil could be useful against AMKL and tolerated better by patients, Crispino says. However, he adds that alisertib is moving forward now because there is urgent need and the drug is available. Meanwhile, Crispino's team and other scientists at Northwestern's Center for Molecular Innovation and Drug Discovery are developing the compound dimethylfasudil into an acceptable anticancer drug for clinical trials, which may take two to three years.

Investigators believe dimethylfasudil may be valuable to fight other types of leukemias because it has broad action against other enzymes that let cancer cells reproduce.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Early Menopause May Double Heart Disease Risk, Study Says
2. Double drug combo could shut down abnormal blood vessel growth that feeds disease
3. Adding bavituximab to second-line chemotherapy doubles response rate
4. MRSA cases in academic hospitals double in 5 years: study
5. Snacking and BMI linked to double effect of brain activity and self-control
6. Moms Pot Use Doubles Risk of Preemie Birth: Study
7. Osteoarthritis risk not diminished in double bundle ACL surgeries
8. As Obesity Rates Rise, Cases of Kidney Stones Double: Study
9. Common acne medication doubles risk of eye infection
10. Study finds number of battery-related emergency department visits by children more than doubles
11. Obesitys Health Costs Double Earlier Estimates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014 The Delta Dental Community Care ... National Children’s Oral Health Foundation: America’s ToothFairy (NCOHF) to ... County Oral Health Zone Program® in California. , The ... a range of local constituent groups and stakeholders in ... tooth decay and its devastating effects on local families. ...
(Date:9/17/2014)... diabetes, quitting smoking, controlling high blood pressure, exercising and ... dementia -- even late in life, according to new ... by Alzheimer,s Disease International, revealed that diabetes can increase ... noted that obesity and an inactive lifestyle are key ... pressure. The researchers suggested that dementia should ...
(Date:9/17/2014)... not properly designed to meet the needs of patients ... families, and major changes to the system are necessary, ... The 21-member committee that wrote the report envisioned ... care and social services and that is high-quality, affordable, ... care planning" for end-of-life by individuals, for improved training ...
(Date:9/17/2014)... most 18-month-olds learn an average of two to five ... how children process information to learn new words as ... study, a University of Missouri researcher has found that ... limit exists as to how many words they can ... their children,s vocabularies and assist speech-language professionals in developing ...
(Date:9/17/2014)... 17, 2014 CarePoint Health became the ... 150 CarePoint Health employees participated in the Ice Bucket ... Association. The event took place on September 9, ... CarePoint Health donated $100 to the ALS Association for ... total of approximately $15,000. The Ice Bucket Challenge was ...
Breaking Medicine News(10 mins):Health News:Delta Dental Community Care Foundation Donation to America's ToothFairy Helps Deliver Critical Services 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 2Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 4Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 5Health News:Babies learn words differently as they age, researcher finds 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 3
... reveals that virgin olive oil is the best among vegetable ... the Annals of Internal Medicine.// It says heart disease risk ... first pressing of olives gives virgin olive oil. Refined oil ... polyphenols than the latter. ,The study was conducted ...
... intelligent ways to conquer the ubiquitous problem of the bulge, ... protein rich diet vis a vis carbohydrate or fat laden ... of fewer calories that wards off obesity. ... the quantity of peptide YY (PYY), a hormone that actually ...
... situation can play an important role in inspiring memory. ... conducting a more in-depth research// on the formation of ... very anticipation of a fearful situation can stir up ... event has occurred. ,The researchers explained that ...
... women patients who wish to preserve their modesty for religious ... in Lancashire have asked a Calderdale firm is to make ... patients for protection of their religious beliefs. ... considered the first of its kind to be introduced in ...
... have a decreased risk of developing diabetes, according to ... The study found that// only 8 percent of the ... percent of those on older drugs. ,The ... Norvasc and Coversyl with a beta-blocker and a diuretic. ...
... the American Medical Association finds that despite the existing ... training, or// residency includes shifts that involve working long ... Medical Education (ACGME) say that they must be allowed ... Medical School, and colleagues said that interns reported working ...
Cached Medicine News:Health News:Anticipation Could Have An Intense Effect On Memory 2Health News:Anticipation Could Have An Intense Effect On Memory 3Health News:Burka Style Inter-faith Gowns For Muslim Patients In UK 2
(Date:9/17/2014)... Sept. 17, 2014   GS1 US ... implement GS1 Standards to support the 2013 Drug ... safety and security in the pharmaceutical supply chain. ... to U.S. Pharmaceutical Supply Chain Business Processes to ... was developed in collaboration with GS1 Healthcare ...
(Date:9/17/2014)... -- Sutro Biopharma, a biopharmaceutical company developing antibody drug ... Merck KGaA, Darmstadt, Germany , which ... States and Canada , ... antibody drug conjugates (ADCs). ADCs are composed of an ... thought to specifically target and deliver the cytotoxic drug ...
(Date:9/17/2014)... ARMONK, N.Y. , Sept. 17 2014 ... Caris Life Sciences is using IBM technical computing ... profiling services for cancer patients. These services deliver ... therapeutic plans for each patient,s unique cancer, which ... costs to the healthcare system in general. ...
Breaking Medicine Technology:New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 2New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 3New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 4Sutro Biopharma and Merck KGaA of Darmstadt, Germany, to Partner on Development of Antibody Drug Conjugates 2Sutro Biopharma and Merck KGaA of Darmstadt, Germany, to Partner on Development of Antibody Drug Conjugates 3Sutro Biopharma and Merck KGaA of Darmstadt, Germany, to Partner on Development of Antibody Drug Conjugates 4Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 2Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 3Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 4
... MALVERN, Pa., May 17, 2012  Egalet Ltd., a privately ... and abuse-deterrent medications, announced today Bob Radie, president and ... Life Sciences Europe conference on May 23 organized ... the company,s patented technology and pipeline of abuse-deterrent opioids ...
... LOUIS, May 17, 2012 , "9 Trends" ... , Helping Members Make Healthier Decisions , ... , Developing New Ways to Comprehensively Manage Specialty Care ... Poor health choices add billions in cost to ...
Cached Medicine Technology:Egalet to Present at Life Sciences Europe Conference 2Poor Health Decisions Cost Billions; New Report Identifies Unhealthy Behavior as Top Concern of Benefit Providers 2Poor Health Decisions Cost Billions; New Report Identifies Unhealthy Behavior as Top Concern of Benefit Providers 3Poor Health Decisions Cost Billions; New Report Identifies Unhealthy Behavior as Top Concern of Benefit Providers 4Poor Health Decisions Cost Billions; New Report Identifies Unhealthy Behavior as Top Concern of Benefit Providers 5
Two-channel, Berman design. Semirigid, nontoxic polyethylene. Individually packaged, 48 per case. Latex Free....
Black elastomer. Smooth finish. Non-Sterile....
Guedel-style enclosed center channel. Semirigid, nontoxic polyethylene with color-coded bite block. Individually packaged, 48 per case. Latex Free....
Includes one of each size airway. Plastic. Color coded for size. Single use. Non-Sterile....
Medicine Products: