Navigation Links
Dosing Begins in Phase 1 Clinical Study Evaluating NKTR-105 in Cancer Patients With Refractory Solid Tumors
Date:2/17/2009

SAN CARLOS, Calif., Feb. 17 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR) announced today that the first patients have been dosed in a Phase 1 dose-escalation study of NKTR-105, a novel PEGylated form of docetaxel. The Phase 1 study will assess the safety, pharmacokinetics and anti-tumor activity of NKTR-105 in approximately 30 patients with refractory solid tumors who have failed all prior available therapies.

"The start of the clinical study for NKTR-105 marks another milestone in the advancement of Nektar's pipeline of innovative therapeutics using our advanced polymer conjugate technology," said Randall Moreadith, M.D., Ph.D., Senior Vice President, Drug Development and Chief Development Officer of Nektar. "NKTR-105 demonstrates a prolonged half-life and tumor exposure as compared to docetaxel. We are excited about the drug's potential to significantly expand therapeutic options for oncologists and patients."

NKTR-105 is a novel form of docetaxel that was developed using Nektar's advanced polymer conjugate technology. Docetaxel is a versatile chemotherapy agent currently approved by the FDA for use in five different cancer indications: breast, non-small cell lung, prostate, gastric and head and neck. Oncolytics such as docetaxel typically have sub-optimal half-lives which can limit their therapeutic efficacy, or have a safety and tolerability profile that limits their use. Nektar's advanced polymer conjugate technology can be used to optimize the bioactivity of these drugs and increase the sustained exposure of active drug to tumor cells in the body.

"Our team at START is extremely pleased to work with Nektar on the first clinical trial of NKTR-105 in cancer patients," said Dr. Anthony Tolcher, Director of Clinical Research at START (South Texas Accelerated Research Therapeutics) and lead
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. AutoGenomics CYP 2C19 Test Used in Study to Personalize Clopidogrel (Plavix) Dosing in Patients
2. Optimal Warfarin Dosing Improves Anticoagulation Control
3. Self-Dosing Pain Medication Errors Too Common: Study
4. Keppra XR(TM) Offers Convenient Dosing For People With Partial Onset Seizures
5. Wide variability in rheumatoid arthritis drug suggests alternative dosing should be considered
6. Anadys Pharmaceuticals Commences Dosing ANA598 in Hepatitis C Patients in Phase Ib Study
7. Hay fever may be best treated with self-adjusted dosing
8. DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results
9. New Improved Dosing Approved for Pennsaid
10. AEterna Zentaris Announces First Patient Dosing for Safety Trial of Phase 3 Program with Cetrorelix in Benign Prostatic Hyperplasia
11. Verizon Wireless Customers Can Now Get Medication Information and Dosing Reminders with the Pill Phone Application on Their Phones

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2009)...009) Wistar Institute researchers and collaborato...k University have identified immune system markers...rs in people at high risk for developing lung canc...Cancer Research , a journal of the American Associ...blood test to detect lung cancer in its earliest p...
(Date:12/1/2009)...MITHFIELD, R.I., Dec. 1 In the wo...ons are hazardous and can result in injury -- or w...on, a handful of persistent bad assumptions are wi... occupational Hearing Conservation Programs (HCPs...paper from Howard Leight, " Bad Assumptions abo...
(Date:12/1/2009)... Abrazo Media Relations-- The Cent...:// www.pedsorthopaedics.com ) located in Mesa, Ar...n Dr. J. Hunt Udall to its practice. ,, Dr. Ud...surgery after recently completing his fellowship t...etts where he focused on adult and pediatric ortho...
(Date:12/1/2009)...appiness declines with age are more likely to enga...g. Their misguided negative view of the aging proc... and encourage them to make the most of the presen...indings 1 by Dr. John Garry and Dr. Maria Lohan f...are published online in Springer,s Journal of Hap...
(Date:12/1/2009)...nsion announces general availability of its new En...d-to-end endpoint management capabilities on a sin...sole architecture. , Scot...a global leader in endpoint management and securit... Management and Security Suite (LEMSS) that will...
Breaking Medicine News(10 mins):Health News:Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer 2Health News:Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer 3Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 2Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 3Health News:Orthopaedic Surgeon Dr. J. Hunt Udall Joins the Center for Pediatric Orthopaedics and Scoliosis as One of Few Trained Doctors to Perform Minimally Invasive Hip Arthroscopy 2Health News:Binge drinking youths find getting old a drag 2Health News:New Lumension Endpoint Management and Security Suite To Deliver End-to-End Endpoint Management Capabilities 2Health News:New Lumension Endpoint Management and Security Suite To Deliver End-to-End Endpoint Management Capabilities 3Health News:New Lumension Endpoint Management and Security Suite To Deliver End-to-End Endpoint Management Capabilities 4Health News:New Lumension Endpoint Management and Security Suite To Deliver End-to-End Endpoint Management Capabilities 5Health News:New Lumension Endpoint Management and Security Suite To Deliver End-to-End Endpoint Management Capabilities 6
... survival for elderly patients with lung cancer ha...care expenditures for lung cancer treatment. The s...ute, and National Bureau of Economic Research rese... rose by less than one month between 1983 and 1997...
...odel of nonprofit fund-raising events and raises ... PHILADELPHIA, Oct. 20 Men and women from,across ...ked 10 miles,throughout Philadelphia today in the ...rts of the American Diabetes,Association. (Photo:...
...r Research, LLC, a pioneer in,the field of Busines...s,first-ever study on the Indian Contract Research...ort titled ,Indian Contract Research Industry, (CR...dia currently stands as one of the highest ranked ...
...ker Nancy Pelosi,issued the following statement to... Stark on the House floor during debate on the Sta...ay,s debate in the House to override the President...hat,Congressman Stark said during the debate was i...
... Pharmaceuticals,Inc. (Nasdaq: ARNA ) announced t...pplement to a shelf registration statement with th... proposed public offering of,10,000,000 shares of ...shares of common stock to cover over-allotments, i...
...r-spurring gene goes to work, researchers say , F... they,ve identified a protein that could play a ke...According to a team at the Kimmel Cancer Center at...as. , However, pp32 is absent in the most aggressi...
Other Medicine News:Health News:Spending more for lung cancer treatment did not substantially increase patients' lives 2Health News:American Diabetes Association Steps Up to Fight Diabetes 2Health News:American Diabetes Association Steps Up to Fight Diabetes 3Health News:EmPower Research Launches Indian CRO Industry Report 2Health News:Arena Pharmaceuticals Announces Public Offering of Common Stock 2Health News:Protein Gives Clues to Pancreatic Cancer 2
(Date:12/1/2009)... Dec. 1 At this year,s annual meet...RSNA), Royal Philips Electronics ( PHG, AEX: PHI) ...t of solutions that provides radiologists the abil...workspot to help drive quality and efficiency. Sh...ll also highlight new capabilities for its portfol...
(Date:12/1/2009)...Dec. 1 ADVENTRX Pharmace...hat a new, recently completed preclinical study ha...ity of ANX-514 and Taxotere® (docetaxel). Sh...NX-514 in South Korea, independently conducted the... confirmation of the bioequivalence and comparable...
(Date:12/1/2009)...CITY, Calif., Dec. 1 Codexis, Inc....and the signing of its second agreement this year ...d,s largest generic drug manufacturer. The new ag...oducts. Codexis announced an earlier agreement wi...t, Teva will use Codexis biocatalysis technology f...
Breaking Medicine Technology:Philips Introduces Multi-Modality Breast Workspace to Complement Comprehensive Portfolio of Diagnostic Imaging Solutions for Breast Care 2Philips Introduces Multi-Modality Breast Workspace to Complement Comprehensive Portfolio of Diagnostic Imaging Solutions for Breast Care 3Philips Introduces Multi-Modality Breast Workspace to Complement Comprehensive Portfolio of Diagnostic Imaging Solutions for Breast Care 4ADVENTRX Pharmaceuticals Reports Additional Pre-Clinical Data for ANX-514 2ADVENTRX Pharmaceuticals Reports Additional Pre-Clinical Data for ANX-514 3Codexis Expands Collaboration with Teva 2Cogdell Spencer Inc Declares Quarterly Dividend 48744 1Cogdell Spencer Inc Declares Quarterly Dividend 48744 2Kaiser Permanente Community Benefit Grant Recipient and Health Activist Rosa Soto Featured in Food Inc Documentary Film 48741 1Kaiser Permanente Community Benefit Grant Recipient and Health Activist Rosa Soto Featured in Food Inc Documentary Film 48741 2Kaiser Permanente Community Benefit Grant Recipient and Health Activist Rosa Soto Featured in Food Inc Documentary Film 48741 3DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 12597 1DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 12597 2DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 12597 3
...ust their function like a radio dial, not an on/of...immune disease may develop,late in life, MEMPHIS,...pital study shows that T cells, the body,s master ...es to govern the cellular,machinery that regulates...ess sophisticated molecular controls that enable t...
...May 12 Arbios Systems, Inc.,(OTC Bulletin Board: ...d,approval from the U.S. Food and Drug Administrat... ("IDE") to begin the pivotal clinical,trial for S...) liver assist,device for blood purification of ac...sease., "We are pleased to have received FDA appr...
Other Medicine Technology:St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity 2St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity 3St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity 4Arbios Receives Approval From the FDA to Initiate Pivotal Trial for SEPET(TM) Liver Assist Device 2Arbios Receives Approval From the FDA to Initiate Pivotal Trial for SEPET(TM) Liver Assist Device 3Arbios Receives Approval From the FDA to Initiate Pivotal Trial for SEPET(TM) Liver Assist Device 4Arbios Receives Approval From the FDA to Initiate Pivotal Trial for SEPET(TM) Liver Assist Device 5
Shoulder Subluxation Inhibitor (SSI)
Comfor™ Shoulder Immobilizer - Universal
...s a critical component of pain relief, functional ...en® Lumbosacral Bracing System™ offers t...vide a high degree of immobilization, unparalled c... . . . even if they gain or lose weight. It combin...
Shoulder Immobilizer with Body Strap
Medicine Products: