Navigation Links
Dopamine Lets Bad Experiences Linger
Date:8/22/2009

th the neurotransmitter dopamine, which is associated with pleasurable and painful stimuli. If a blocker for the dopamine receptor was injected into the hypothalamus of the brain 12 hours after the shock -- but not immediately after the shock or nine hours later -- the rats effectively forgot about the experience: seven and 14 days after the shock, they exhibited little to no latency. Conversely, if a dopamine receptor activator was injected 12 hours following a weak shock, the rats remembered the experience as if they had received a strong shock.

In other words, at a specific point following the shock, the researchers could pharmacologically alter these animals' brains, causing them either to forget the traumatic experience, or to remember it more strongly.

The implication, said Roy Wise, chief of the behavioral neuroscience branch in the Intramural Research Program at the National Institute on Drug Abuse, is that "the memories we thought were solid and accurate are not."

The effect depended on the activity of a specific brain protein called BDNF, and on interaction of the hypothalamus with another brain region called the ventral-tegmental area.

"I think it's a really exciting study," said Philip Corlett, of the University of Cambridge and Yale University. "Understanding more about how long-term memories are formed may have huge implications for psychiatric diseases, which often are diseases of memory."

Assuming the results can be replicated in humans -- which is by no means certain, given that the rats were treated via shunts in the brain, a delivery method unlikely to be used in humans -- potential applications run the gamut from boosting learning to ameliorating the effects of psychiatric diseases. But perhaps the most obvious human application involves post-traumatic stress disorder (PTSD).

"If you could get to somebody soon after the traumatic experience, you might be able to interfere with this conso
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Food restriction increases dopamine receptor levels in obese rats
2. Antidepressants Can Increase Depression, Impulsivity and Suicide Risk by Decreasing Dopamine
3. Identification of dopamine mother cells could lead to future Parkinsons treatments
4. Why dopamine freezes parkinson patients and drives drug addicts
5. Risk takers, drug abusers driven by decreased ability to process dopamine
6. Guardians Dental Network Experiences Double-Digit Growth
7. WellPoint Taps Zagat Survey to Help Consumers Rate Experiences with Their Doctors
8. Greenway Experiences Quick Success in the Community EHR Marketplace by Securing Contracts with 10 Community-Based Health Organizations
9. Blind Tibetan Teenagers Featured in Award-Winning Film, Blindsight, Unite with Students from Junior Blind of America to Share Life Experiences
10. Candidate Experiences Life in Homecare Workers Shoes
11. MedAptus Experiences Record Growth of 70 Percent
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dopamine Lets Bad Experiences Linger
(Date:12/22/2014)... (PRWEB) December 22, 2014 The ... than ever, having invested more than $5 million ... members, veterans and their families. , This includes ... a dozen nonprofits, helping with: veteran entrepreneurship; community ... and life-coaches for severely injured veterans. , “The ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount ... Reward, a local organization that provides services to veterans ... Located on a couple hundred acres in the hills ... world class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet ... years ago to support U.S. Service men and women, ...
(Date:12/22/2014)... 22, 2014 TheHardwareCity.com now stocks MagnoGrip ... many useful features. Customers of the large online tool ... new gloves delivered to their home or workplace with ... tools that incorporate heavy duty magnets, which make work ... workers to store metal parts on the back of ...
(Date:12/22/2014)... 2014 A substantial percentage of ... tomography (CT) to evaluate abnormal findings on outpatient ... according to a new study published online in ... findings show that radiologist recommendations for additional imaging ... patient care. , RAIs, which have grown 200 ...
(Date:12/21/2014)... December 22, 2014 Recently, BambooFlooringChina.com, a ... strand woven bamboo flooring collection , and launched a ... The promotion is valid until Jan. 30, 2015. , ... bamboo is the hardest bamboo flooring available today; it ... that of traditional teak hardwoods. Strand woven bamboo is ...
Breaking Medicine News(10 mins):Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... application is unclear , , TUESDAY, April 7 (HealthDay News) -- You ... if you,re a rat. , New research suggests that diets ... lot of fat: It,s easier for them to develop a risk ... humans. Even so, they raise questions about protein in the development ...
... researchers have found that delayed-enhancement magnetic resonance imaging (DE-MRI) ... progression for patients with atrial fibrillation (AF), a little ... million Americans and causes more than 66,000 deaths a ... this technology for AF appears in the April 7 ...
... men with the autoimmune disease systemic lupus erythematosus (SLE) ... puberty. Hormones secreted by the body are therefore believed ... the disease. A new large, population-based observational study found ... an increased risk of SLE, particularly among women who ...
... disparities in the delivery of healthcare occur even ... suggests that some of the differences in health ... due to patient preferences. Rheumatoid arthritis (RA) treatment ... symptom relief, long-term reduction of disability, adverse events ...
... The Healthcare Information Technology Standards Panel ... 2009 work to provide greater focus on provisions of the ... next 90 days. ARRA contains numerous technology and privacy provisions ... are related to standards and HITSP,s work, including:, ...
... 2007, Blue Cross Blue Shield of Georgia (BCBSGa) announced that ... psychologists by approximately 19%. This new rate is about ... handyman per hour. However, unlike your mechanic, BCBSGa wants ... paid 10 years ago by BCBSGa. In 1998 clinical ...
Cached Medicine News:Health News:Protein Might Be a Troublesome Nutrient 2Health News:U study shows MRI-based method holds promise for predicting treatment outcomes in patients with AF 2Health News:Oral contraceptives associated with increased risk of lupus 2Health News:Patient preferences play role in racial disparities in rheumatoid arthritis treatment 2Health News:HITSP to Address Provisions of American Recovery and Reinvestment Act 2Health News:HITSP to Address Provisions of American Recovery and Reinvestment Act 3Health News:Blue Cross Blue Shield of Georgia Is Skimping on Mental Health Care, Says Georgia Psychological Association 2Health News:Blue Cross Blue Shield of Georgia Is Skimping on Mental Health Care, Says Georgia Psychological Association 3
(Date:12/19/2014)... 18, 2014 Capnia, Inc. (NASDAQ: ... medical diagnostics based on its proprietary Sensalyze™ Technology ... announced financial results for the third quarter and ... "Following the completion of our initial public offering ... the recently initiated CoSense® commercial launch," said Anish ...
(Date:12/19/2014)... 2014 Baptist Health Lexington is the first facility ... full Atrial Fibrillation with Electrophysiology Services (EPS) Accreditation status from ... fibrillation is the most common cardiac arrhythmia and has become ... lead to stroke and possible death. More than 5 million ... atrial fibrillation and the numbers are rapidly increasing as the ...
(Date:12/19/2014)... KANSAS CITY, Kan. , Dec. 18, 2014 ... PETX ), a biopharmaceutical company focused on ... for companion animals, today announced positive results from ... company,s innovative drug for treating pain in dogs ... demonstrated improvements in pain assessment scores that were ...
Breaking Medicine Technology:Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... Applied Seals North America, Inc. , ... ultraclean manufacturing of nanoelectronics and biomedical products, has ... Silicon Valley headquarters with the hiring of design ... company,s product engineering team to provide additional technical ...
... Pa., Oct. 25 PennDOT and the Pennsylvania State ... influence of prescription and over-the-counter medication can be just ... and illegal drugs. PennDOT will work ... to step up impaired-driving enforcement, with increased emphasis on ...
Cached Medicine Technology:Applied Seals North America Bolsters Engineering and Applications Services in Silicon Valley With Addition of Design Engineer 2PennDOT, State Police Caution Motorists About Dangers of Driving Under Influence of Legal Drugs 2
Slick® Disposable Endotracheal Stylet, Nylon-coated wire, Malleable core, Sureloc Stop helps maintain desired length for patient safety. Handle forming capability for better grip. Sterile. Single...
... spine manipulation. Prevent dental and soft tissue ... alternative to X-ray. Light-guided intubation is based ... in the neck. This technique takes advantage ... relative to the esophagus. A well-defined, circumscribed ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
Medicine Products: