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Date:7/9/2013

rmine the roots of heart disease in people with a family history of coronary disease. They analyzed information gathered from 1,483 healthy siblings of people who had coronary events before the age of 60 and who were followed for five to 25 years. Siblings of people with early-onset coronary artery disease (CAD) are twice as likely of developing it themselves.

Among other things, study participants filled out well-being surveys and received a score, on a scale of 0 to 110, which gauged cheerful mood, level of concern about health, whether they were relaxed as opposed to anxious, energy level and life satisfaction. Over the course of an average 12-year follow-up, the researchers documented 208 coronary events heart attacks, sudden cardiac death, acute coronary syndrome, and the need for stents or bypass surgery in the sibling group.

The researchers found that participants' positive well-being was associated with a one-third reduction in coronary events; among those deemed at the highest risk for a coronary event, there was nearly a 50 percent reduction. The findings took into account other heart disease risk factors such as age, smoking, diabetes, high cholesterol levels and high blood pressure.

To validate their result, the researchers then looked at similar information in a general population using data from 5,992 participants in the first National Health and Nutrition Examination Survey (NHANES). In this population, over an average 16-year follow-up, there were 1,226 coronary events (20.5 percent). They found that this group also benefitted from a cheerful temperament, which reduced their risk of a coronary event by 13 percent.

The findings held whether the participants were white or African-American, men or women.


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Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

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