Navigation Links
Don't forget to eat your greens
Date:1/25/2010

LIVERMORE, Calif. - The age old reminder to always eat your greens isn't just for kids anymore.

Not only are the vitamins and minerals good for you, but eating greens could also save your life, according to a recent study led by the National Nuclear Security Administration's Lawrence Livermore National Laboratory scientists.

Researchers Graham Bench and Ken Turteltaub found that giving someone a small dose of chlorophyll (Chla) or chlorophyllin (CHL) - found in green leafy vegetables such as spinach, broccoli and kale - could reverse the effects of aflatoxin poisoning.

Aflatoxin is a potent, naturally occurring carcinogenic mycotoxin that is associated with the growth of two types of mold: Aspergillus flavus and Aspergillus parasiticus. Food and food crops most prone to aflatoxin contamination include corn and corn products, cottonseed, peanuts and peanut products, tree nuts and milk.

Bench and Turteltaub, working with colleagues from Oregon State University and an industry partner, Cephalon Inc., found that greens have chemopreventative potential.

Aflatoxins can invade the food supply at anytime during production, processing, transport and storage. Evidence of acute aflatoxicosis in humans has been reported primarily in developing countries lacking the resources to effectively screen aflatoxin contamination from the food supply. Because aflatoxins, particularly aflatoxin B1 (AFB1), are potent carcinogens in some animals, there is interest in the effects of long-term exposure to low levels of these important mycotoxins on humans.

The study used AMS to provide aflatoxin pharmacokinetic parameters previously unavailable for humans, and suggest that chlorophyll and chlorophyllin co-consumption may limit the bioavailability of ingested aflatoxin in humans, as they do in animal models, according to Bench.

Exposure to environmental carcinogens has been estimated to contribute to a majority of human cancers, especially through life-style factors related to tobacco use and diet. Notable examples are the tobacco-related carcinogens; heterocyclic amines produced from sustained, high-temperature cooking of meats; and the fungal food contaminants aflatoxins.

The team initially gave each of three volunteers a small dose of carbon 14 labeled aflatoxin (less than the amount that would be found in a peanut butter sandwich). In subsequent experiments the patients were given a small amount of Chla or CHL concomitantly with the same dose of carbon 14 labeled aflatoxin. By using LLNL's Center for Accelerator Mass Spectrometry, the team was able to measure the amount of aflatoxin in each volunteer after each dosing regimen and determine whether the Chla or CHL reduced the amount of aflatoxin absorbed into the volunteers.

"The Chla and CHL treatment each significantly reduced aflatoxin absorption and bioavailability," Bench said.

"What makes this study unique among prevention trials is, that we were able to administer a microdose of radio-labeled aflatoxin to assess the actions of the carcinogen directly in people. There was no extrapolation from animal models which often are wrong," Turteltaub said.


'/>"/>

Contact: Anne Stark
stark8@llnl.gov
925-422-9799
DOE/Lawrence Livermore National Laboratory
Source:Eurekalert

Related medicine news :

1. 6 Day Dental and Orthodontics Gets an A+ Check Up
2. Long Island Children's Orthodontist, Dr. Inna Gellerman, Celebrates Season of Giving with Holiday Drives and Events
3. Interleukin Genetics Receives Approval To Sell its PST(R) Periodontal Disease Genetic Test in New York
4. Scientific Journal Gene Therapy Reports That Cardiums Gene Activated Matrix Technology Accelerates Periodontal Tissue Regeneration
5. Florida Gentle Dental Dentists Giving Away Smile Makeover and Orthodontic Braces at 7th Annual Our Kids World Family Fun Festival
6. Patients with moderate to severe periodontitis need evaluation for heart disease risk
7. Top Dentist Issues Opinion on Health Benefits of Cutting-Edge Orthodontics
8. Over half of people with rheumatoid arthritis have periodontitis
9. Journal of Periodontology and the American Journal of Cardiology develop joint clinical recommendations
10. Scientists find shared genetic link between the dental disease periodontitis and heart attack
11. New Jersey Orthodontist Patrick T. Cuozzo Launches User-Friendly, State-of-the-Art New Website
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The International ... promote standards of excellence for the field of eating disorders, announces the opening ... 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017 West Pharmaceutical Services, Inc. ... for injectable drug administration, today announced that it will ... on Thursday, October 26, 2017, and will follow with ... expectations at 9:00 a.m. Eastern Time. To participate on ... The conference ID is 94093362. ...
(Date:10/11/2017)... 11, 2017  Caris Life Sciences ® , a ... promise of precision medicine, today announced that St. Jude ... Oncology Alliance™ (POA) as its 17 th member. ... Jude Crosson Cancer Institute will help develop standards of ... tumor profiling, making cancer treatment more precise and effective. ...
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
Breaking Medicine Technology: