Navigation Links
Donor aortic graft improves reconstruction after partial laryngectomy
Date:5/21/2012

Massachusetts General Hospital (MGH) surgeons have developed a new technique for reconstructing the larynx after surgery for advanced cancer. In the May Annals of Otology, Rhinology and Laryngology, they describe how this approach which uses cryopreserved aortas from deceased donors to replace removed larynx tissue allowed patients to avoid a permanent tracheotomy and maintain voice and swallowing function with no need for immunosuppressive medications. The pioneering surgery was a collaborative effort between Steven Zeitels, MD, director of the MGH Center for Laryngeal Surgery, and John Wain, MD, surgical director of the MGH Lung Transplantation Service.

"Without this new reconstructive technique, most of these patients would have required a total laryngectomy," says Zeitels, corresponding author of the report. "I don't believe anything like this has been achieved before especially for larynx cancer reconstruction in patients whose tumors recurred after radiotherapy."

Although small laryngeal tumors can be successfully removed through minimally invasive laser surgery or treated with radiation, advanced tumors require more invasive procedures to remove the affected area, especially when chemotherapy and radiation have failed as initial treatment. In these situations, problems with the healing of tissues previously exposed to radiation and the lack of reliable reconstructive techniques have meant that a majority of patients having partial laryngectomy still needed a permanent tracheotomy an opening through the neck and into the trachea resulting in substantial voice and swallowing dysfunction. Since the quality of life would probably be better with removal of the entire larynx, patients and their surgeons often chose a total laryngectomy.

To address the reconstructive limitations of partial laryngectomy, Zeitels and Wain developed an approach using the body's largest blood vessel, the aorta, to reconstruct the larynx. The MGH surgeons first used a previously frozen aortic graft for reconstruction after partial laryngectomy for recurrent cancer in 2009. Over the next two years, they performed the procedure on 15 patients, 8 of whom had previously received radiation therapy. All of these procedures were performed in one operation, combining both the tumor removal and reconstruction at the same time, and no immunosuppressive medications were needed.

Of that initial group of patients, all were able to have their postoperative tracheotomy tubes removed and resume breathing normally. All resumed speaking without the need for assistive devices, although their vocal quality depended on how much tissue had been removed, and all but one recovered and maintained swallowing function. Two patients had recurrence of their advanced tumors that required subsequent total laryngectomy. No stents were needed to keep patients' airways open, unlike in pilot trials using similar aortic grafts to reconstruct the trachea, which have had limited success.

"The shape of the aorta, which approximates that of the removed laryngeal tissue, and its ability to serve as a surface for healing within the airway are unique characteristics of these grafts that other forms of reconstruction do not provide," says Wain.

Zeitels adds, "The success of this procedure is remarkable, since the aortic tissue has held up extremely well against the stresses of a non-sterile environment, exposure to refluxing stomach fluids and the mechanical forces of swallowing and coughing. Given the success in this extremely challenging surgical scenario, it's likely that there will be many other uses for cryopreserved vascular grafts as supportive structures and tissue patches for surgery in other parts of the body."


'/>"/>

Contact: Mike Morrison
mdmorrison@partners.org
617-724-6425
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. Restrictions on Plasma From Female Donors May Need Revisiting
2. Kidneys From Older Donors Suitable for Seniors
3. Kidney Donors Go On to Lead Long, Healthy Lives
4. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
5. Living donor exchange poses new option for liver transplantation
6. Donor kidneys from Hepatitis C patients needlessly denied to patients with that infection
7. Hundreds of Donor Kidneys Tossed Away Each Year
8. Donors Welcome the Advance Market Commitment's First Long-Term Supply Commitments
9. Test Spots Potential Organ Donors Among Coma Patients
10. Six-Time Egg Donor Creates "Ask Kate", an Online Forum to Help Future Egg Donors
11. Matching Heart Donors by Race Unnecessary?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... Orion, Clarkston Michigan (PRWEB) , ... May 24, ... ... new Certified Nurse Midwife, Roberta Jordan. , Roberta Jordan is a Certified ... degree from Grand Valley State University and then went on to complete her ...
(Date:5/24/2016)... Indianapolis, IN (PRWEB) , ... May 24, 2016 ... ... employee benefits advisory organization, is pleased to welcome new Partner Firm Austin & ... a personalized, consultative approach to insurance, employee benefits, HR consulting, benefits technology, and ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... Center at Sentara Northern Virginia Medical Center located in Woodbridge, VA. The ... surgical services into a single site. , The new 2 story building houses ...
(Date:5/24/2016)... ... May 24, 2016 , ... Mental health watchdog Citizens Commission on Human ... renowned professor of psychiatry Thomas Szasz, is continuing its protest against the use of ... exhibit in Atlanta, Georgia. The opening of the exhibit follows CCHR’s recent protest at ...
(Date:5/24/2016)... ... May 24, 2016 , ... Loma Linda University Health ... adult hospital and expanded Children’s Hospital. Over 3,000 people looked on as the shovels ... out the event photo slidehsow. , During the program, Richard H. Hart, MD, ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 Non-invasive diagnostic ... of multiple diseases; ,Technology to be presented at Yissum’s ... Yissum Research Development Company of the Hebrew University of ... research agreement with Aurum Ventures MKI, the technology investment arm ... a new diagnostic approach for early detection of multiple ...
(Date:5/22/2016)... May 23, 2016 DS ... anti-fibrotic and anti-inflammatory compound DS102 in chronic obstructive ... non-alcoholic steatohepatitis (NASH) patients. Recent DS ... in lung tissue and has bronchodilatory, anti-inflammatory and ... administration. The Company will publish further detail on ...
(Date:5/20/2016)... ReportsnReports.com adds "Plaque Psoriasis ... research report with comprehensive information on the therapeutic ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
Breaking Medicine Technology: