Navigation Links
Dolphins' 'remarkable' recovery from injury offers important insights for human healing
Date:7/20/2011

Washington, DC A Georgetown University Medical Center (GUMC) scientist who has previously discovered antimicrobial compounds in the skin of frogs and in the dogfish shark has now turned his attention to the remarkable wound healing abilities of dolphins.

A dolphin's ability to heal quickly from a shark bite with apparent indifference to pain, resistance to infection, hemorrhage protection, and near-restoration of normal body contour might provide insights for the care of human injuries, says Michael Zasloff, M.D., Ph.D.

For a "Letter" published today in the Journal of Investigative Dermatology, Zasloff, an adjunct professor at GUMC and former Dean of Research, interviewed dolphin handlers and marine biologists from around the world, and reviewed the limited literature available about dolphin healing to offer some new observations about what he calls the "remarkable" and "mysterious" ability of dolphins to heal.

"Much about the dolphin's healing process remains unreported and poorly documented," says Zasloff. "How does the dolphin not bleed to death after a shark bite? How is it that dolphins appear not to suffer significant pain? What prevents infection of a significant injury? And how can a deep, gaping wound heal in such a way that the animal's body contour is restored? Comparable injuries in humans would be fatal. "

Zasloff explains the dolphin healing process by synthesizing scattered reports of known aspects of dolphin biology.

For example, he proposes the same diving mechanism (diving reflex) that diverts blood from the periphery of the body during a dolphin's deep plunge down in water depths also could be triggered after an injury. Less blood at the body's surface means less blood loss.

As for pain, Zasloff's review suggests the dolphin's apparent indifference "clearly represents an adaptation favorable for survival." Still, he says, the neurological and physiological mechanisms engaged to reduce pain remain unknown.

The prevention of infection is perhaps less of a mystery. Despite gaping wounds and deep flesh tears, those who observe dolphins following shark bites have not noted significant rates of infection. Zasloff says it's likely that the animal's blubber holds key answers.

Blubber and its composition have been studied extensively for many years because it accumulates many toxic pollutants of human origin, such as heavy metals from its food sources, which allows scientists to monitor environmental pollution, Zasloff says. It is therefore well documented that blubber also contains natural organohalogens which are known to have antimicrobial properties and antibiotic activity.

"It's most likely that the dolphin stores its own antimicrobial compound and releases it when an injury occurs," Zasloff predicts. "This action could control and prevent microbial infection while at the same time prevent decomposition around the animal's injury."

Finally, Zasloff explores the ability of the dolphin's wound to heal in a way that restores the dolphin's body contour. He says the dolphin's healing ability is less like human healing and more like regeneration.

"The repair of a gaping wound to an appearance that is near normal requires the ability of the injured animal to knit newly formed tissues with the existing fabric of adipocytes, collagen and elastic fibers," he explains. "The dolphin's healing is similar to how mammalian fetuses are able to heal in the womb."

Brent Whitaker, M.S., D.V.M., deputy executive director for biological programs at the National Aquarium in Baltimore describes Zasloff's letter as "thought provoking." Zasloff consulted with Whitaker as part of his research.

"It makes sense that the dermal tissues of the dolphins would evolve mechanisms to protect them from the microbes ever present in the water in which these animals live," Whitaker says. "Other aquatic animals have developed protective strategies that allow them to cope with water-borne microflora. [Dr. Zasloff's] letter suggests a unique and intriguing hypothesis which may begin to explain how dolphins, and perhaps other cetaceans, survive significant soft-tissue wounds in the wild without the aid of antibiotics or clinical care."

"It is very clear from working with marine mammals that the ability to heal is 'enhanced' from what we see with terrestrial mammals," says Leigh Ann Clayton, DVM, DABVP, director of the Department of Animal Health at the National Aquarium, who also advised Zasloff. "Dr. Zasloff proposes some fascinating mechanisms of action in healing. It is exciting to begin exploring these mechanisms more completely."

In his letter, Zasloff presents the case histories of two shark-bitten dolphins, Nari and Echo, at the Tangalooma Wild Dolphin Resort in Moreton Island, Australia. The reports document the healing process of the dolphins with photos to eloquently demonstrate how and how quickly two dolphins heal from severe shark injuries.

"The Tangalooma dolphin care team is continuously astounded at the remarkable natural ability of the dolphins that visit us, in overcoming severe shark bite injuries with what seems to be indifference," says Trevor Hassard, director of Tangalooma. "We learn so much from the lives of other animals. Perhaps Dr Zasloff's contribution will bring the dolphin's remarkable healing capacities to the attention of the medical research community."

"My hope is this work will stimulate research that will benefit humans," says Zasloff. "I feel reasonably certain that within this animal's healing wounds we will find novel antimicrobial agents as well as potent analgesic compounds."


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. Dolphins Get By With a Little Help From Their (Female) Friends
2. Dolphins May Warn of Health Risks in Humans
3. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
4. Dolphins health shed light on human and ocean health
5. Publication of World Health Report 2000 an act of remarkable courage, says school expert
6. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
7. Delaying Intravenous Feeding of ICU Patients May Aid Recovery
8. Mothers Play Important Role in Recovery From Mental Illness
9. Corticosteroids May Speed Pneumonia Recovery in Some
10. Substantial recovery rate with placebo effect in headache treatment
11. Rep. Giffords to Get Skull Patch in Latest Step in Recovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... ... Reltok Nasal Products proudly announces that Boston Medical Products, Inc., a leading ... specialty, has added the KOTLER NASAL AIRWAY™ to its diverse product line. , A ... safety device secured by nasal surgeons onto the floor of the nasal passages, at ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the market leader ... led by Eastside Partners, with participation from existing investor Martin Ventures. The ... accelerate its technology and product roadmap. , “Jvion is experiencing significant ...
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored ... satisfaction survey, earning them second place for Tampa’s Best Places to Work. They were ... “This is a great accomplishment for our team,” says RMS Human Resources Manager Irene ...
(Date:4/29/2016)... ... April 29, 2016 , ... The infertility specialists at HRC Fertility/Orange County (HRC/OC) ... Daniel A. Potter -- are proud of the recent release of their 2014 in ... SART published the latest verified data for 375 U.S. member clinics. *Preliminary ...
(Date:4/29/2016)... ... April 29, 2016 , ... Natren, Inc. ... line of probiotics, Petbiotics ™, as they fondly call them. As animal ... groups networking for their non-profit organizations. Animal rescues across the nation face huge ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 29, 2016 Acquisition Expands ... Product Development Capabilities in North America ... . Indegene ( http://www.indegene.com ), ... acquisition of Skura Corporation,s life science business. Skura,s ... sales enablement technology for life science organizations and ...
(Date:4/29/2016)... 29, 2016 ... Sanofi, leader mondial et ... résultats pour le premier trimestre 2016. ... Contamine, commente les résultats du premier ... pour le reste de l,année. ...
(Date:4/29/2016)... Glycotope GmbH, a clinical-stage immuno-oncology company built ... Dr. Alfredo Zurlo as Chief Medical Officer. ... years clinical experience and a proven track record in ... at Mologen AG where he was Chief Medical Officer ... held various positions at F Hoffmann La Roche and ...
Breaking Medicine Technology: