Navigation Links
Dogs Help in Hunt for New Cancer Drugs
Date:3/23/2009

Research with canines may one day lead to new therapies to benefit humans

MONDAY, March 23 (HealthDay News) -- Joe Bauer got the call on a Friday afternoon.

A 10-year-old bichon frise named Oscar had developed anal sac adenocarcinoma, a particularly virulent cancer in dogs, and had been given only three months, at best, to live. The dog's owners, from Milford, Mass., were heartbroken and planned to have Oscar put down the next day.

Instead, Bauer, who at the time was a staff scientist at the Cleveland Clinic's Center for Hematology & Oncology Molecular Therapeutics, shipped an experimental cancer drug free-of-charge to Oscar's veterinarian -- essentially enrolling Oscar in a clinical trial that could end up benefitting not only suffering dogs but humans as well.

Treating dogs as a prelude to finding new cancer drugs for humans is an idea that's catching on.

"Dogs are benefiting more and more as [people] recognize the value of studying new cancer therapies -- not just drugs -- in dogs," said Dr. Ann E. Hohenhaus, a staff veterinarian and board-certified dog/cat oncologist at the Animal Medical Center in New York City. "There are a couple of reasons why the dog is so good."

For one thing, the mice usually studied in cancer research are genetically bred to develop tumors. Dogs, like humans, spontaneously develop tumors.

"The tumors we ultimately want to treat in people spontaneously happen because people have darn bad luck," Hohenhaus said. "The same thing is true for dogs. That aspect of tumors in dogs is fabulous in terms of mimicking what happens in humans."

Also, not only are dogs similar to humans in their genetic makeup (certainly more similar than mice), they are also exposed to the same environmental factors that humans are.

Experimental chemotherapy drugs might garner response rates of 80 percent or higher in mice, but that figure often plunges to 10
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... August 31, 2015 , ... ... 66th Annual Convention & Expo October 5th & 6th in San Antonio, TX. ... AHCA/NCAL convention brings industry professionals from all over the country come to share ...
(Date:8/30/2015)... ... August 30, 2015 , ... Lizzie’s Lice Pickers ... to school special. The company is currently offering lice head checks for just $10, ... company is offering a 10% discount on their lice treatment products. “With kids returning ...
(Date:8/30/2015)... Fl (PRWEB) , ... August 30, 2015 , ... ... Executive Vice President Jeff Fernandez will lead the expansion of global cosmeceutical and ... and skin care experience having spent the last 25 years working in operations, ...
(Date:8/29/2015)... , ... August 30, 2015 , ... ... 15, 2015 — 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/electronicinformedconsent , ... a simple digital handwritten signature. , Clinical trial sites can now ...
(Date:8/29/2015)... ... ... Dr. Tim Novelli, DC., Founder and President of the Patriot Project, is a ... field in the military. All too often VA hospitals treat patients with harmful and ... the VA program over a decade ago, the reality is that only 10% of ...
Breaking Medicine News(10 mins):Health News:Intellitec Solutions to feature Microsoft Dynamics GP at AHCA/NCAL 66th Annual Convention & Expo 2Health News:Lizzie’s Lice Pickers Announces Back to School Head Check Special and Discounted Lice Treatment Products 2Health News:NPI Executive Vice President Leads Cosmeceutical Expansion 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 3Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 4Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2
... Back Chronic Disease,Initiatives, WASHINGTON, Oct. 20 ... many Americans are forgoing basic,medical care in the ... fight against chronic disease and support for care ... sense in tough economic times,--dining out less often ...
... chances of survival, study found , , MONDAY, Oct. 20 (HealthDay ... lymphoma increases if one is poor but decreases if the ... published in the Dec. 1 issue of Cancer , ... that blacks tend to have a higher risk of death ...
... LITTLE ROCK, Ark., Oct. 20 Heifer International, ... perfect,holiday gift alternative for the green-minded client, the ... for tighter gift budgets.,Heifer focuses on doing one ... 2 billion people living on less than $2 ...
... to Offer "Safe and Sober Free Cab Ride Home" , ... Alameda, ... will be adding Halloween to its list of holidays for the Safe ... up with Veterans Cab and Yellow Cab in Alameda and Luxor Cab ...
... member of PPI class for treatment for GERD and Erosive ... ... Company,Limited ("Takeda") today announced that Takeda Global Research and,Development Center, Inc., a ... Drug Administration (FDA) that,the agency will not be able to complete its ...
... Hydrate and Soothe Young Throats, FARMINGDALE, N.Y., ... approaches, Integrated Beverage Group, Ltd. (IBG), a manufacturer,of ... newest,product -- Children,s Throat Cooler(R). This non-medicated ready-to-freeze,liquid ... wish to choose a 100%,drug free product to ...
Cached Medicine News:Health News:Nation's Economic Downturn Threatens Continuity of Care for Chronic Conditions 2Health News:Heifer International: The Greener Good for Holiday Giving 2Health News:Free Cab Rides Home for Halloween in Alameda, Oakland, Berkeley and San Francisco, California 2Health News:Free Cab Rides Home for Halloween in Alameda, Oakland, Berkeley and San Francisco, California 3Health News:FDA Adds Three Months to Review of Takeda's New Drug Application for TAK-390MR 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) 3
(Date:8/28/2015)... PUNE, India , August 28, 2015 ... "Cancer Biomarker Market by Tumor (Breast, Lung, Prostate) Type ... Immunoassay) Application (Diagnostic, Drug Discovery, Prognostic) & Geography - ... Biomarkers Market is expected to reach around 17,689.0 Million ... the forecast period of 2015 to 2020. ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... announced the addition of the "Investigation Report on ... Tobramycin is a traditional antibiotic whose eye ... for the treatment of potential infection or inflammation caused ... China are able to produce tobramycin, ...
(Date:8/28/2015)... 2015 Research and ... the "Investigation Report on China,s Insulin Aspart ... Developed by Novo Nordisk, insulin aspart (under ... drug for the treatment of diabetes. Compared with ... insulin analog, starts working fast and reports higher ...
Breaking Medicine Technology:Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Tobramycin Market, 2015-2019 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2
... Study Data in Pediatric Patients,Presented at the ... PARSIPPANY, N.J., Nov. 11 Daiichi Sankyo,Inc. ... pivotal study supporting,the use of colesevelam HCl ... were presented for the first time at ...
... November 11, 2008 at 9:00 am ET, ... (Nasdaq: ANSV ) today announced that the ... of capsaicin, narrowly missed its,primary endpoint of reducing ... four to 32 hours post-surgery. The same,measure was ...
Cached Medicine Technology:Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 2Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 3Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 4Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 5Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 6Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia 7Anesiva Announces Adlea ACTIVE-1 Phase 3 Clinical Results, Ceasing of Zingo Commercial Operations and Restructuring 2Anesiva Announces Adlea ACTIVE-1 Phase 3 Clinical Results, Ceasing of Zingo Commercial Operations and Restructuring 3Anesiva Announces Adlea ACTIVE-1 Phase 3 Clinical Results, Ceasing of Zingo Commercial Operations and Restructuring 4Anesiva Announces Adlea ACTIVE-1 Phase 3 Clinical Results, Ceasing of Zingo Commercial Operations and Restructuring 5
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: