Navigation Links
Dogs Help in Hunt for New Cancer Drugs
Date:3/23/2009

Research with canines may one day lead to new therapies to benefit humans

MONDAY, March 23 (HealthDay News) -- Joe Bauer got the call on a Friday afternoon.

A 10-year-old bichon frise named Oscar had developed anal sac adenocarcinoma, a particularly virulent cancer in dogs, and had been given only three months, at best, to live. The dog's owners, from Milford, Mass., were heartbroken and planned to have Oscar put down the next day.

Instead, Bauer, who at the time was a staff scientist at the Cleveland Clinic's Center for Hematology & Oncology Molecular Therapeutics, shipped an experimental cancer drug free-of-charge to Oscar's veterinarian -- essentially enrolling Oscar in a clinical trial that could end up benefitting not only suffering dogs but humans as well.

Treating dogs as a prelude to finding new cancer drugs for humans is an idea that's catching on.

"Dogs are benefiting more and more as [people] recognize the value of studying new cancer therapies -- not just drugs -- in dogs," said Dr. Ann E. Hohenhaus, a staff veterinarian and board-certified dog/cat oncologist at the Animal Medical Center in New York City. "There are a couple of reasons why the dog is so good."

For one thing, the mice usually studied in cancer research are genetically bred to develop tumors. Dogs, like humans, spontaneously develop tumors.

"The tumors we ultimately want to treat in people spontaneously happen because people have darn bad luck," Hohenhaus said. "The same thing is true for dogs. That aspect of tumors in dogs is fabulous in terms of mimicking what happens in humans."

Also, not only are dogs similar to humans in their genetic makeup (certainly more similar than mice), they are also exposed to the same environmental factors that humans are.

Experimental chemotherapy drugs might garner response rates of 80 percent or higher in mice, but that figure often plunges to 10
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Today the Brain Injury Association of America (BIAA) ... recognize and support the more than 5.3 million Americans who ... leads the nation in observing Brain Injury Awareness Month by ... theme for the 2015 to 2017 campaign is: Not Alone. ... educating the general public about the incidence of brain injury ...
(Date:3/2/2015)... GBCHealth, a prominent business coalition ... activities and investments in global health issues, today ... members to serve on the organization’s Board of ... Strategist and Co-founder of Partners In Health, and ... Abbasi, General Manager of Global Health and Medical ...
(Date:3/2/2015)... Los Angeles, CA (PRWEB) March 02, 2015 ... Jimmy Buffett tickets at the Hollywood Bowl . This ... can add customer appreciation promo code JIMMY-BUFFETT-2015 for added ... celebrate because their favorite performer will be headlining at ... This concert will be on Thursday, October 22nd ...
(Date:3/2/2015)... FL (PRWEB) March 02, 2015 While ... with Title VI of the Civil Rights Act, the ... and hearing loss are bringing light to the value ... statistics reveal that nearly 1 in 20 U.S. children ... in 10 in some major cities.(1) Stratus Video ...
(Date:3/2/2015)... March 02, 2015 ZoomCare announced ... remake American healthcare. Zoom will expand its Portland ... clinics and advanced care studios delivering urgent care, ... services, specialty care and outpatient surgery. With its ... to almost all healthcare needs outside of hospitalization. ...
Breaking Medicine News(10 mins):Health News:Brain Injury Association of America Launches “Not Alone” Campaign for Brain Injury Awareness Month 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 3Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 4Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 5Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 3Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 4Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 2Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 3
... people in order to show- how eating patterns can stop you ... aged 60 or over living in many countries . They ... ate lots of green leafy vegetables, beans, olive oil, nuts and ... meat and sugar was also linked to keeping a smoother skin.// ...
... inhibitor ramipril, used for the treatment of hypertension, can ... thereby lowering the risk of stroke and myocardial infarction ... Heat Outcome Prevention Evaluation (HOPE) study showed the drug ... broad range of patients – those with normal or ...
... chronic bronchitis, research has found. It has been thought that ... survey of almost 16,000 people aged 18 to 47 ... opposite. ,The researchers found that the disease affects ... Young smokers were particularly at risk, and men were more ...
... occur in several forms, but systemic lupus erythematosus (SLE)--usually ... It is an incurable disease marked by inflammation and ... the joints, skin, heart, kidney and central nervous system. ... mistakenly attacks the body's own tissue. ,New research ...
... to believe that a gene-based treatment for heart disease may ... blood vessels in hearts with severe hardening of the arteries ... patients suffering with heart disease.// ,Treatment options for ... that open blocked arteries and improve blood flow to the ...
... A new study from Brazil has found that coffee ... blood levels of cholesterol and the protein homocysteine.High levels ... disease. Some of the compounds, called terpenoids, are known ... Right, of Marylandl University Hospital ,US, explained that "it ...
Cached Medicine News:Health News:New light on Cardiology 2
(Date:3/2/2015)... -- Edison Investment Research, a leading ... full coverage of Abzena  Highlights of ... biotech analysts Christian Glennie and Dr ... offers a range of key services and technologies ... biological products. Antitope (immunogenicity testing, protein engineering, cell ...
(Date:3/2/2015)... Mount Elizabeth Novena Hospital will soon become the first ... treat cancer using the TrueBeam™ STx system for radiotherapy ... VAR ).  At a Grand Opening event last Friday, ... of treatment including radiosurgery, a precise method of using ... from outside the body, without performing surgery.  ...
(Date:3/2/2015)... -- Valencia Technologies Corporation (" Valencia ") ... small device for the treatment of high blood pressure ... double-blinded, controlled trial are compelling and provide the Company ... succeed in a large U.S. trial for FDA approval. ... Valencia has successfully raised more than 2.2 ...
Breaking Medicine Technology:Edison Initiates Coverage on Abzena 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 3Valencia Technologies Implants its 48th Patient, Continues Equity Crowdfunding 2
... and ST. AUGUSTINE, Fla., Aug. 10, 2011 ... hospitals, has selected the Sunrise Enterprise ™ suite ... (NASDAQ: MDRX).  In addition to implementing Sunrise within the ... Electronic Health Record (EHR) and practice management solution ...
... 10, 2011 Simbionix USA Corporation, the ... products for medical professionals and the healthcare industry, is ... in the UK for its innovative PROcedure Rehearsal Studio ... is a first in industry product, allowing clinicians ...
Cached Medicine Technology:Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 2Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 3Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 4Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 5Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 6Patent Granted for Simbionix Procedure Rehearsal Studio™ 2
... Trellis Infusion Catheter enables the physician to ... fluid, and disperse the agent by means ... Trellis is a multi-lumen catheter with two ... and infusion holes located between these balloons. ...
... OptiEdge offers design innovations that ensure outstanding ... handling. The biostable acrylic material of the ... the patented OptiEdge is designed to both ... of contact with the posterior capsule; and ...
... posterior chamber lenses are optical implants for ... in the visual correction of aphakia in ... The optical portion consists of a high ... have biconvex optics and supporting haptics of ...
... an intraocular lens that doesn't stop ... natural human lens, the new ACRYSOF® ... high-energy blue light. But while it ... your patient's view. That's just as ...
Medicine Products: