Navigation Links
Does the body's immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
Date:1/8/2014

New Rochelle, NY, January 7, 2014Packaging replacement genes in viruses is an effective method to deliver them to target tissues, but the human body mounts an immune response against the virus. The systemic and local immune reactions induced by an adeno-associated virus (AAV)-based gene therapy to treat lipoprotein lipase deficiency, approved for use in Europe, does not affect the safety of gene therapy or expression of the replacement gene for at least one year after delivery, according to a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Human Gene Therapy website.

Valeria Ferreira and coauthors, uniQure BV and Academic Medical Center, Amsterdam, the Netherlands, and University of Montreal and Chicoutimi Hospital, Quebec, Canada, evaluated measures of inflammation and adverse clinical events and the expression of a replacement lipoprotein lipase (LPL) gene that was injected intramuscularly into patients with LPL deficiency. The gene was packaged in an AAV vector, as described in the article "Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPLS447X) in a phase II clinical trial of Lipoprotein Lipase deficiency (LPLD) gene therapy."

"The clinical data published in this paper were critical to the approval of Glybera," says James Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia. "Furthermore, they provide context for laboratory measurements of immune responses which apparently did not impact product performance."


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related medicine news :

1. Platinum Soursop-The natural health supplement to improve immune system and enhance Mood is finally available for purchase
2. PDL-1 antibody could help immune system fight off influenza viral infection, study suggests
3. Boosting the immune system to treat brain cancer
4. Predicting ovarian cancer survival through tumor-attacking immune cells
5. Golden staph paralyzes our immune defenses
6. Study identifies protein essential for immune recognition, response to viral infection
7. Mutations of immune system found in breast cancers
8. Keep the Immune System Strong, Especially When Traveling for the Holidays, with the Portable Travel Skin Brush from Sublime Beauty®
9. New discovery on early immune system development
10. Tailored pre-transplant therapy boosts survival rate in rare immune deficiency
11. CNIO scientists decipher how the immune system induces liver damage during hepatitis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Does the body's immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
(Date:2/22/2017)... ... February 22, 2017 , ... Our ... to overwork even the sharpest brain. , Power On, a mental performance enhancer ... over clocking the brain. Each capsule contains Cognizin® Citicoline, a branded form of ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... The ... to the thousands of individuals who have recently fallen victim to America’s opioid epidemic. ... in Orange County, California, where they are free from the shame, stigma, and ...
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the award-winning TV series that ... On The Water (HOW), a non-profit organization dedicated to helping military veterans relax, rehabilitate, ... ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish with war veteran Justin ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... chronic conditions reported skipping doses or not filling a prescription because they could ... rates of cost-related problems getting medications were 30-60%*. At the same ...
(Date:2/22/2017)... ... ... Sideline Products participated in the World Horse Expo held in Timonium, MD ... production crew. Tom Seay’s program “Best of America by Horseback” is broadcasted on ... be featured on April 6, 2017. After the broadcast, the clip will be posted ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... The Senior Care Pharmacy Coalition (SCPC) today ... of Representatives that will curtail the ability of drug ... extracting retroactive direct and indirect remuneration (DIR) fees in ... the Medicare program. S. 413, introduced by ... Jon Tester (D-MT), and House companion bill, H.R. ...
(Date:2/22/2017)... 2017 Henry Schein Medical today announced ... with Rijuven, which develops innovative digital medical devices, ... practitioners. CardioSleeve is a stethoscope ... sound signals, transmits real-time data to any smartphone ... to help physicians provide diagnostic interpretation of a ...
(Date:2/22/2017)... 2017  Allergan plc (NYSE: AGN), a leading ... Gold sponsor of the Alzheimer,s Foundation of America,s ... tour commemorates AFA,s15 years of educating individuals about ... The tour will include AFA,s free Concepts in ... of the AFA Quilt to Remember. ...
Breaking Medicine Technology: