Navigation Links
Does our DNA determine how well we respond to stem-cell transplantation?
Date:1/19/2011

SEATTLE Do genetic variations in DNA determine the outcome and success in patients who undergo stem-cell transplantation to treat blood cancers and predict complications? The National Heart, Blood and Lung Institute of the National Institutes of Health has awarded a $4.3 million, four-year grant to Fred Hutchinson Cancer Research Center to help find out.

John Hansen, M.D., a member of the Hutchinson Center's Clinical Research Division and medical director of Clinical Immunogenetics at Seattle Cancer Care Alliance, will lead the genome-wide association study of all patients who have been treated with an allogeneic hematopoietic cell transplant (HCT) at the Hutchinson Center between 1992 and 2010. Allogeneic stem-cell transplants involve infusing healthy stem cells from the blood or bone marrow of related and unrelated donors into the blood of patients whose blood-cell-producing bone marrow is diseased by leukemia and lymphoma, among other illnesses.

The new study will expand upon earlier research begun in 2006 and will increase the sample size three fold to 5,000 transplants, thus improving the power of identifying the genetic variants associated with HCT outcome.

Among the study's goals are to identify genetic variations among patients that could account for the risk and severity of acute and chronic graft-versus-host disease, organ toxicity, opportunistic infection, relapse and overall survival. Genetic variants associated with HCT outcome will be validated as markers for assessing risk prior to patients receiving transplants and to enhance counseling and treatment planning.

Researchers also will use the results to gain insights into disease processes responsible for treatment complications and the rationale for developing novel targeted therapies for preventing and controlling these complications.

Bone-marrow and stem-cell transplantation was developed at the Hutchinson Center as highly successful treatments for blood cancers and some autoimmune diseases. Researchers at the Hutchinson Center and its clinical partner, SCCA, have performed more transplants cumulatively over the years than any other center in the world. In 2010, about 60,000 people worldwide underwent bone- or stem-cell transplants, and by the end of 2011 it is expected that about 1 million people worldwide will have been treated by this life-saving therapy, which was pioneered by the Hutchinson Center's E. Donnall Thomas, M.D., who in 1990 received the Nobel Prize in physiology or medicine for this advance.


'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Mayo Clinic determines lifetime risk of adult rheumatoid arthritis
2. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
3. MRI may help determine time of stroke onset
4. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
5. For sufferers of an early-onset dementia, career choice may determine location of disease in brain
6. OHSU researchers able to determine brain maturity through analyzing MRI scans
7. Micro-RNA determines malignancy of lung cancer
8. Location determines social network influence, CCNY-led team finds
9. Can I buy you a drink? Genetics may determine sensitivity to other peoples drinking behavior
10. Delivery Method May Determine the Bacteria Babies Acquire
11. New possibility to determine the severity of appendicitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... SAN LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast ... purpose of this dance is to provide a night of fun for teens with and ... to help everyone feel welcomed and included at the event. The dance will take place ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Basketball is a ... integral part of the Peety PoppersTM series, sign language translation is featured in the ... health and wellness in Peety PoppersTM lessons has a sign language translator to teach ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Dignity Health named ... Hospital Emergency Room –Mesa. The new facility is licensed under Dignity Health ... “Dr. Bingham is an excellent leader and will ensure our new freestanding emergency room ...
(Date:2/11/2016)... CA (PRWEB) , ... February 11, 2016 , ... According ... System, a product marketed as a weight loss dietary supplement, is being recalled due ... group Beverly Hills Physicians, because there is not a single supplement on the market ...
(Date:2/11/2016)... ... 2016 , ... Registered nurses, licensed practical nurses and nursing aides who treat ... Act, Time to Heal” on Thursday, February 25 from 9:00 to 11:00 a.m. at ... Chedda, president of ANSA Consultants, who will discuss clinical best practices throughout the continuum ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Breast Cancer Therapeutics in Asia-Pacific Markets to ... (APAC) breast cancer market will experience considerable expansion from ... a Compound Annual Growth Rate (CAGR) of 8.5%. --> ... - states that the Asia-Pacific (APAC) ... in 2014 to $3.4 billion by 2021, at a Compound ...
(Date:2/11/2016)... , February 11, 2016 ... at Worldwide Clinical Trials, will present at this year,s Summit ... the Hyatt Regency in Miami, FL. ... partnerships to optimize study execution, supporting SCOPE,s "Improving Site Study ... take place on Thursday, Feb. 25 at 11:05 a.m. ...
(Date:2/11/2016)... , Feb. 11, 2016 Exactus ... company providing high-quality specialty pharmacy care for those ... today it has achieved full Specialty Pharmacy Accreditation ... organization dedicated to promoting health care quality through ... --> The URAC accreditation process ...
Breaking Medicine Technology: