Navigation Links
Does our DNA determine how well we respond to stem-cell transplantation?
Date:1/19/2011

SEATTLE Do genetic variations in DNA determine the outcome and success in patients who undergo stem-cell transplantation to treat blood cancers and predict complications? The National Heart, Blood and Lung Institute of the National Institutes of Health has awarded a $4.3 million, four-year grant to Fred Hutchinson Cancer Research Center to help find out.

John Hansen, M.D., a member of the Hutchinson Center's Clinical Research Division and medical director of Clinical Immunogenetics at Seattle Cancer Care Alliance, will lead the genome-wide association study of all patients who have been treated with an allogeneic hematopoietic cell transplant (HCT) at the Hutchinson Center between 1992 and 2010. Allogeneic stem-cell transplants involve infusing healthy stem cells from the blood or bone marrow of related and unrelated donors into the blood of patients whose blood-cell-producing bone marrow is diseased by leukemia and lymphoma, among other illnesses.

The new study will expand upon earlier research begun in 2006 and will increase the sample size three fold to 5,000 transplants, thus improving the power of identifying the genetic variants associated with HCT outcome.

Among the study's goals are to identify genetic variations among patients that could account for the risk and severity of acute and chronic graft-versus-host disease, organ toxicity, opportunistic infection, relapse and overall survival. Genetic variants associated with HCT outcome will be validated as markers for assessing risk prior to patients receiving transplants and to enhance counseling and treatment planning.

Researchers also will use the results to gain insights into disease processes responsible for treatment complications and the rationale for developing novel targeted therapies for preventing and controlling these complications.

Bone-marrow and stem-cell transplantation was developed at the Hutchinson Center as highly successful treatments for blood cancers and some autoimmune diseases. Researchers at the Hutchinson Center and its clinical partner, SCCA, have performed more transplants cumulatively over the years than any other center in the world. In 2010, about 60,000 people worldwide underwent bone- or stem-cell transplants, and by the end of 2011 it is expected that about 1 million people worldwide will have been treated by this life-saving therapy, which was pioneered by the Hutchinson Center's E. Donnall Thomas, M.D., who in 1990 received the Nobel Prize in physiology or medicine for this advance.


'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Mayo Clinic determines lifetime risk of adult rheumatoid arthritis
2. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
3. MRI may help determine time of stroke onset
4. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
5. For sufferers of an early-onset dementia, career choice may determine location of disease in brain
6. OHSU researchers able to determine brain maturity through analyzing MRI scans
7. Micro-RNA determines malignancy of lung cancer
8. Location determines social network influence, CCNY-led team finds
9. Can I buy you a drink? Genetics may determine sensitivity to other peoples drinking behavior
10. Delivery Method May Determine the Bacteria Babies Acquire
11. New possibility to determine the severity of appendicitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... (PRWEB) , ... February 26, 2017 , ... ... patients after receiving cognitive rehabilitation, according to a study released today at the ... that cognitive rehabilitation programs are proven to be effective in improving cognitive function ...
(Date:2/24/2017)... ... February 24, 2017 , ... HealthPostures, ... Go. Core benefits and advantages built into the home office sit stand solution ... and feel. Ability to gain the benefits embedded in the TaskMate Go are ...
(Date:2/24/2017)... ... 24, 2017 , ... WHAT: , The New Jersey Tech ... well as advocacy for the state and region‘s technology businesses, hosted their 2017 ... Council's Innovation Forecast event highlights innovation throughout the region from small to large ...
(Date:2/24/2017)... ... ... The Smart Machine Age is here, and it’s disrupting everything. Not only ... jobs in the United States may be taken over by technology in the next ... who steamrolls over colleagues is drawing to a close. Success will belong to those ...
(Date:2/24/2017)... , ... February 24, 2017 , ... Healthcare Associates ... Medical Center at Craig Ranch building at 8080 State Highway 121, Suite 210, McKinney, ... with easy access to Highway 121. , As the practice has grown, the need ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017 Research and Markets has ... & Trends - Industry Forecast to 2025" report to their ... The ... of around 23.8% over the next decade to reach approximately $330.5 ... estimates and forecasts for all the given segments on global as ...
(Date:2/24/2017)... Research and Markets has announced the addition of the "Dry eye ... ... eye Drugs Price Analysis and Strategies - 2016, provides drug pricing data ... the following questions: What are the key ... positioned in the Global Dry eye market? What are ...
(Date:2/24/2017)... NEW YORK , Feb. 24, 2017 ... Monteverde & Associates PC , a boutique securities ... New York City , announces that a ... of Massachusetts  against Inotek Pharmaceuticals ... purchasers of the Company,s securities between July 23, 2015 and ...
Breaking Medicine Technology: