Navigation Links
Does our DNA determine how well we respond to stem-cell transplantation?
Date:1/19/2011

SEATTLE Do genetic variations in DNA determine the outcome and success in patients who undergo stem-cell transplantation to treat blood cancers and predict complications? The National Heart, Blood and Lung Institute of the National Institutes of Health has awarded a $4.3 million, four-year grant to Fred Hutchinson Cancer Research Center to help find out.

John Hansen, M.D., a member of the Hutchinson Center's Clinical Research Division and medical director of Clinical Immunogenetics at Seattle Cancer Care Alliance, will lead the genome-wide association study of all patients who have been treated with an allogeneic hematopoietic cell transplant (HCT) at the Hutchinson Center between 1992 and 2010. Allogeneic stem-cell transplants involve infusing healthy stem cells from the blood or bone marrow of related and unrelated donors into the blood of patients whose blood-cell-producing bone marrow is diseased by leukemia and lymphoma, among other illnesses.

The new study will expand upon earlier research begun in 2006 and will increase the sample size three fold to 5,000 transplants, thus improving the power of identifying the genetic variants associated with HCT outcome.

Among the study's goals are to identify genetic variations among patients that could account for the risk and severity of acute and chronic graft-versus-host disease, organ toxicity, opportunistic infection, relapse and overall survival. Genetic variants associated with HCT outcome will be validated as markers for assessing risk prior to patients receiving transplants and to enhance counseling and treatment planning.

Researchers also will use the results to gain insights into disease processes responsible for treatment complications and the rationale for developing novel targeted therapies for preventing and controlling these complications.

Bone-marrow and stem-cell transplantation was developed at the Hutchinson Center as highly successful treatments for blood cancers and so
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic determines lifetime risk of adult rheumatoid arthritis
2. Jefferson study determines bone marrow stromal stem cells may aid in stroke recovery
3. MRI may help determine time of stroke onset
4. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
5. For sufferers of an early-onset dementia, career choice may determine location of disease in brain
6. OHSU researchers able to determine brain maturity through analyzing MRI scans
7. Micro-RNA determines malignancy of lung cancer
8. Location determines social network influence, CCNY-led team finds
9. Can I buy you a drink? Genetics may determine sensitivity to other peoples drinking behavior
10. Delivery Method May Determine the Bacteria Babies Acquire
11. New possibility to determine the severity of appendicitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Each year trauma accounts for approximately 42 ... across the nation (according to the Centers for ... Hospital Ambulatory Medical Care Survey collected data from ... They estimated that there were between 3.5 and 4.4 ... diagnosis of broken bone or fracture. , When ...
(Date:12/24/2014)... Epigenetics finds applications in a large ... drug discovery, developmental biology, and research for metabolic and ... the most widely used techniques for the discovery and ... of cancer is rapidly growing worldwide. In 2012, there ... deaths, and 32.6 million people living with cancer (within ...
(Date:12/24/2014)... (PRWEB) December 24, 2014 New studies reveal ... to hearing loss related depression (March 6, 2014, JAMA Otolaryngology*). ... gradual hearing loss (about 50 percent according to recent polls) ... effect on how a person feels and relates to the ... overall improvements are also made by way of:, ...
(Date:12/24/2014)... December 25, 2014 Today, Yunx.co.uk, a ... evening dresses and other special occasion outfits, unveils ... models are offered at discounted prices, up to 80% ... young ladies with their fashionable designs, gorgeous looks and ... exception. The business is devoted to designing and offering ...
(Date:12/24/2014)... HealthDay Reporter TUESDAY, Dec. 23, 2014 ... sex for one year will be allowed to donate blood in ... a 31-year ban on donations from men who have sex with ... intention to release a new draft guidance in early 2015 that ... The FDA is changing its policy based on data from ...
Breaking Medicine News(10 mins):Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 3Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 2Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 3Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 4Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 5Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 6Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 3
... or GAD, have abnormalities in the way their brain unconsciously ... School of Medicine study, and the study authors say the ... our understanding of how emotion is regulated in everyday life. ... American Journal of Psychiatry. According to the National ...
... , ... Dr. Peter H.R. Green M.D. for an enlightening discussion on celiac disease, one of the ... unknowingly has celiac. Dr. Green diagnoses over 2,400 celiac patients a year, one being day-time ... ...
... study found , WEDNESDAY, Feb. 10 (HealthDay News) -- Damage ... thinking and feeling in patients, a finding that adds new ... makeup of the mind, researchers say. , The findings, published ... based on research in patients who had surgery to remove ...
... , PUYALLUP, Wash. , Feb. 10 ... and the American Recovery and Reinvestment Act became household ... imaging and data management integration project with interoperability provider ... for MINW patients even after the completion of the ...
... Oncology (ASO), the official journal of the Society ... with the American Society of Breast Surgeons beginning in ... leading monthly publication that features original articles on the ... Dr. William Curtis, Executive Vice President for Clinical ...
... National Poll Finds Voters Prefer Tobacco Tax to Other Tax ... Raising Iowa ,s cigarette tax by $1 ... new annual revenue to help close the state,s budget shortfall, while ... released today by a coalition of public health organizations. , (Logo: ...
Cached Medicine News:Health News:People with anxiety disorder less able to regulate response to negative emotions, study shows 2Health News:People with anxiety disorder less able to regulate response to negative emotions, study shows 3Health News:Multi-Award Winning Author Tina Turbin Interviews Special Guest Dr. Peter H.R. Green, M.D. On The Thrive in Balance Radio Show 2Health News:Physical Changes in Brain Linked to Altered Spirituality 2Health News:Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements 2Health News:Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements 3Health News:Annals of Surgical Oncology adds new society affiliation 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking 3
(Date:12/24/2014)... 24, 2014  Novastem, a leader in regenerative ... in its study for ischemic stroke at Clinica ... ischemic strokes account for 87 percent of all ... in the study, entitled "Internal Research Protocol in ... Stem Cells and Intrathecal Administration of Neural Stem ...
(Date:12/24/2014)... China, Dec. 24, 2014 /PRNewswire/  -- Tianyin Pharmaceutical ... pharmaceutical company that specializes in the patented biopharmaceutical, ... active pharmaceutical ingredients (API) released unaudited preliminary financial ... 2015. Fiscal Year 2015 Ended September ... $9.7 million compared with $14.7 million in 1Q14 ...
(Date:12/24/2014)...  The International Trade Commission (ITC) issued its final decision ... In a notice issued on December 23, the ITC ruled ... its humidifier was invalid. BMC President, James ... very excited with the ITC,s decision in this case. This ... since the very beginning on the key patents in the ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2
... Janssen Alzheimer Immunotherapy, together with its collaborator ... pleased to announce the Alzheimer,s Association™, the world,s ... and research, as a new beneficiary of ... Everything campaign. Through this campaign, mountaineer and ...
... DIEGO, May 10, 2011 /PRNewswire/ -- Pf enex ... Pf enex Expression Technology™ platform, announced today a ... the global biologics business of AstraZeneca. The agreement provides ... Technology and scientific resources for the development of bioprocesses ...
Cached Medicine Technology:Alzheimer's Association Salutes Advocate and Mountaineer Now Climbing Everest as Part of The 7 Summits Climb for Alzheimer's 2Alzheimer's Association Salutes Advocate and Mountaineer Now Climbing Everest as Part of The 7 Summits Climb for Alzheimer's 3Alzheimer's Association Salutes Advocate and Mountaineer Now Climbing Everest as Part of The 7 Summits Climb for Alzheimer's 4Pfenex Announces Strategic Collaboration With MedImmune for the Use of Pfenex Expression Technology™ 2
100% Silicone Foley Catheter Kits 2-Way...
ULTRAMER Foley Catheter...
Foley Catheters (Latex) 2-Way...
Silicone Elastomer-Coated Latex Foley Catheters 3-Way...
Medicine Products: