Navigation Links
Does dad matter? New study looks at his environmental exposure in reproductive success
Date:6/11/2014

AMHERST, Mass. A new three-year, $440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples' reproductive success, via epigenetic modifications of sperm DNA. Phthalates are compounds found in plastics and personal care products that are estimated to be detectable in nearly 100 percent of the U.S. population.

Pilsner and colleagues will examine the possible influence of paternal phthalate exposure on sperm quality and embryo development and whether DNA methylation in sperm cells may be a pathway by which a father's exposure influences these endpoints. The new study is among the first to investigate the influence of phthalate on sperm epigenetics in humans.

Pilsner says, "What we're asking, basically, is whether dad's environmental health contributes to reproductive success, and if so, how is that transmitted to offspring?"

Unlike genetic mutations that affect DNA and the genome, epigenetic markers turn genes on and off to regulate cell processes, which if altered may lead to disease, he explains. If the genome and DNA are like computer hardware, as others have described it, the epigenome is like software, running programs telling genes what to do. Environmental exposures such as smoking, air pollution and metals have been linked to epigenetic changes associated with health risks. DNA methylation is one type of epigenetic mechanism and can be assessed by high-throughput analyses.

Phthalate exposure, known to disrupt endocrines, is associated in human studies with changes in semen quality, androgen levels, birth outcomes and offspring neurodevelopment, but a mechanism has not been clearly identified, Pilsner says.

He adds, "Until now, no one has investigated the sperm epigenome in the context of environmental exposures. Now we know there is this additional la
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Brilliant Nutrition Puts End to the Debate: Does Size Really Matter?
2. Study identifies risk factors for hospital readmissions
3. Miriam Hospital study shows how to make statewide health campaigns more effective
4. Mammography has led to fewer late-stage breast cancers, U-M study finds
5. Study shows health policy researchers lack confidence in social media for communication
6. Sleep apnea tied to diabetes in large study
7. Study: When hospital workers get vaccines, community flu rates fall
8. Study: New test predicts if breast cancer will spread
9. UIC conducts phase I drug study for advanced pancreatic cancer
10. Study finds coordinated approach improves quality of primary care
11. Study finds risk of recurrence low in smallest HER2+ breast cancer tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Does dad matter? New study looks at his environmental exposure in reproductive success
(Date:7/23/2014)... 23, 2014 Thousands of DePuy Pinnacle ... in a federal multidistrict litigation underway in U.S. District ... According to an Order dated July 18th, U.S. District ... payment of a $1,000 fee for the preservation and ... Among other things, the Order noted that there is ...
(Date:7/23/2014)... RIVERSIDE, Calif. Fragile X syndrome ( FXS ) ... behaviors, and other behaviors on the autistic spectrum, as ... inherited cause of mental impairment and the most common ... University of California, Riverside have published a study ... behaviors in FXS. Appearing online today (July 23) in ...
(Date:7/23/2014)... The voice on the recording was low and calm as the ... infected with the human immunodeficiency virus (HIV) that causes AIDS: “My ... know I was on the floor flat on my face boohooing, ... the recording ended less than 10 minutes later. “Don’t feel like ... it is just God setting you up for something greater,” the ...
(Date:7/23/2014)... Roanoke, Virginia (PRWEB) July 23, 2014 ... Levelers headquarters in Roanoke, Virginia on Friday, July 18. ... Virginia Amateur Sports Subway Commonwealth Games, an Olympic-style event ... in its first year as a premier sponsor of ... lifestyles to people of all ages and all activity ...
(Date:7/23/2014)... (HealthDay News) --,Jealousy may not be the sole domain ... downright possessive when it comes to the love of ... what was actually a stuffed dog, the real puppies ... stuffed dog aside, report researchers from the University of ... surfaced when owners were attending to the stuffed dog ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 2Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 3Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 4Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3Health News:US Olympian Chad Hedrick Visits Foot Levelers 2Health News:Dogs Can Get Jealous, Too 2
... Abbott, has agreed to lower the prices of Kaletra/Aluvia ... US dollars, on a request from the World Health ... indicated for the treatment of HIV-1 infected adults and ... with other antiretroviral agents. It is in a category ...
... in the April 10, 2007, issue of Neurology, has ... suffering ‘Restless Legs Syndrome (RLS). The risk increases in ... at the University of Montreal’s Sacré-Coeur Hospital, ten people ... laboratory, where researchers monitored periodic leg movements and blood ...
... groups are joining forces to fund three promising lung ... Society// are contributing $370,000 to fund the first-ever LUNGevity ... The grants will go to three researchers whose novel ... cancer develops and could lead to more effective treatments. ...
... to a survey, which was carried out to mark Mental ... respondents know two friends// who have experienced mental distress at ... showed that almost 90 percent of those suffering from mental ... of shame for appearing weak or because they felt their ...
... Public Health has found that the state level rates of suicide ... ownership of firearm. ,"We found that where there ... Professor of Health Policy and Management at HSPH and lead author ... 15 leading causes of death in the U.S.; among persons less ...
... entire life from one moment to the next, and experts ... than the psychological after-effects. ,"Every person reacts differently ... emergency rescue services in the northern German port city of ... shock like screaming is seldom the case, she says. "Some ...
Cached Medicine News:Health News:Abbott to Subsidize Price of HIV Drug 2Health News:Restless Legs Syndrome Poses Risk of Cardiovascular Disease 2Health News:Groups Join Forces to Fund Promising Lung Cancer Research 2Health News:Household Guns Associated With Higher Rates of Suicide in US 2Health News:Accident Victims Often Need Psychological Help 2
(Date:7/23/2014)... , July 23, 2014 Research ... the "Global Electrophysiology Ablation Catheters Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Catheter ablation ... or destroy faulty electrical pathways from sections of ... known as cardiac arrhythmias). Cardiac arrhythmias can be ...
(Date:7/23/2014)... 23, 2014 Creekridge Capital, an independent ... new vendors so far in 2014 to their ... vendors are from both the healthcare and technology ... large, well-known multi-national companies. Each of these new ... financing products including: standard leasing products, subscription solutions, ...
(Date:7/23/2014)... MINNEAPOLIS , July 23, 2014  Nonin Medical, ... leader in noninvasive medical monitoring, announced today that ... OEM, has been elected Chairman of the American Telemedicine ... Board of Directors. The ATA is the ... advanced remote medical technologies. The ATA and its diverse ...
Breaking Medicine Technology:Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 2Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 3Creekridge Capital Signs Several New Vendor Partners 2Nonin Medical Announces that Mark VanderWerf has been Elected Chairman of the American Telemedicine Association's Industry Council 2
... QGLY ) today reported net sales of $11.8 ... to $11.5 million,reported for the same period in 2006. ... $25.9 million compared to $27.9 million reported,for the same ... nine months of 2007 reflect a net sales,increase for ...
... parents provide different responses ... ORLANDO, Fla., Oct. 25 According ... parents have,significantly different perceptions of the importance ... the patients, most,concerning behavior. The study, which ...
Cached Medicine Technology:The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 2The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 3The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 4The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 5The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 6The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy 7A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities 2A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities 3A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: