Does MRI pose more than minimal risk in pediatric... ( the authors write. The authors also...)

Does MRI pose more than minimal risk in pediatric research?

Date:10/4/2011

, the authors write.

The authors also compared the death rates of children undergoing MRIs versus children riding in motor vehicles, which poses the highest risk of mortality to healthy children. The motor vehicle risk ranges from 6 deaths per 100 million car trips for children ages 14 years and younger to 40 per 100 million for children ages 15 to 19. "Thus, the risk of death from an MRI examination (four per 100 million) is clearly less than the risk of death from a car trip," the authors conclude.

As for psychological harm, in studies of children ages 10 to 18 years old who had MRI scans, 12 percent said they felt disturbed by the confined space, 16 percent said they were bothered by the noise, and 1.2 percent could not complete their MRI scan due to claustrophobia. But these percentages were lower on average than the percentages of children who report fears associated with anxiety disorders in one study of children 8 to 13 years of age, for example, 49 percent reported fears associated with subclinical anxiety and 22 percent met the full criteria of an anxiety disorder.

When an MRI examination calls for the injection of a contrast dye, there is the risk of allergic reactions, such as fever, headache, and anaphylaxis. The authors compared these risks with the risk of allergic reactions following routine vaccinations: while the risk of local and minor systemic reactions from MRI contrast dyes (4 percent to 6 percent) is comparable to the risk of minor reactions from routine vaccinations, the risk of anaphylaxis from MRI contrast dyes (7.5 per 100,000 doses) is higher than the risk of anaphylaxis from vaccinations. "MRI with contrast enhancement therefore does not meet the minimal-risk standard," they conclude.

They also conclude that the risk from sedation in MRI protocols, which includes gastrointestinal complaints (18 percent to 37 percent) and motor imbalance (66 percent to 85 percent), does not meet the minimal-risk standar
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Contact: Michael Turton
turtonm@thehastingscenter.org
845-424-4040 x242
The Hastings Center
Source:Eurekalert

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