Navigation Links
Does Helicobacter pylori eradication therapy prevent gastric cancer?
Date:9/25/2009

Although it has been demonstrated that Helicobacter pylori causes gastric cancer, it is still controversial that whether H. pylori eradication therapy is effective in primary prevention of gastric cancer. This is especially important for Yamagata Prefecture, a region of Japan with the second highest incidence of gastric cancer in the world.

A research article to be published on September 14, 2009 in the World Journal of Gastroenterology addresses this question. A research team led by Dr. Katsuhiro Mabe from Division of Gastroenterology of KKR Sapporo Medical Center did a multicenter, prospective cohort study in residents of Yamagata Prefecture between 2000 and 2007. They compared the incidence of gastric cancer between patients with H. pylori-positive peptic ulcer who underwent H. pylori eradication (eradication group) or conventional antacid therapy (non-eradication group) at the patients discretion. A total of 4133 patients with a mean age of 52.9 years were registered, and 56 cases of gastric cancer were found over a mean follow-up period of 5.6 years. The sex- and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group, was 0.58 (95% CI: 0.281.19). The ratios by follow-up period of < 1 year, 13 years, and > 3 years were 1.16 (0.275.00), 0.50 (0. 171.49), and 0.34 (0.091.28), respectively, which indicated that longer follow-up tended to be associated with better prevention of gastric cancer. There was no significant difference in incidence of gastric cancer between patients with and without successful eradication therapy. However, among patients with duodenal ulcer, which is more common in younger individuals, the incidence of cancer was significantly less in those with successful eradication.

The results of the study, which revealed no overall prevention of gastric cancer by eradication therapy for peptic ulcer during observation highlight the importance of longer and careful follow-up after eradication therapy. Furthermore, the significant efficacy of treatment observed in younger patients suggests the need to eradicate H. pylori as early as possible.


'/>"/>

Contact: Ye-Ru Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?
2. Helicobacter pylori can multiply in autophagic vesicles
3. How do Lactobacilli treat Helicobacter pylori-related diseases?
4. Helicobacter pylori inhibits intercellular communication of cultured gastric cells
5. Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
6. How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
7. A low prevalence of H pylori in HIV-positive patients
8. The Kingdom of Saudi Arabia Commits $30 Million to Polio Eradication Efforts
9. BioNeutrals Ygiene(TM) Achieves Worlds Fastest Kill Time With a 100% Total Spore Eradication Verified In Independent Sporicidal/Sterilant Test
10. Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication
11. Global Health Community Commits Over $630 Million in Aggressive Push for Polio Eradication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... MO (PRWEB) , ... January 16, 2017 , ... St. Louisans are well-aware of the ... , This year’s influenza shot seems to be having no effect on keeping ... at least half of the people around are coughing, sneezing, or sniffling ...
(Date:1/16/2017)... ... 16, 2017 , ... Board-certified oculoplastic surgeon Dr. Mehryar (Ray) ... journal of The American Society for Aesthetic Plastic Surgery, in which he details ... to correct drooping, retracted lower eyelids, which usually result from genetics, injury, thyroid ...
(Date:1/16/2017)... ... , ... One thing common to all types of cancer is that it’s ... The money spent screening for and treating cancer in the United States is estimated ... more than in any other country that has an advanced healthcare system, sometimes spending ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Chief Executive Officer of the medical device company, effective immediately. , “This is ... “Kevin has a strong track record in medical device market development and ...
(Date:1/15/2017)... ... January 15, 2017 , ... In this role, Courtney will be responsible ... the asthma & allergy friendly mark. This certification program was created by ASL and ... products to be more suitable for the 60+ million people living in the U.S. ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... India , January 16, 2017 ... Market Research, titled, "Sterilization Technologies Market by Type and ... the global sterilization technologies market is expected to reach ... growing at a CAGR of 5.8% from 2016 to ... market in 2015, with more than half share, in ...
(Date:1/16/2017)...   Linde Gas North America LLC  today announced ... business of The Service Center LLC, a market leading provider ... providers in the Midwest and Southeast regions of the U.S. ... , The Service Center also has facilities in ... . Its primary services include: ...
(Date:1/16/2017)... FRANCISCO, Calif. , Jan. 16, 2017  Rigel ... on January 3, 2017 and January 16, 2017 the ... grant of inducement stock options to purchase an aggregate ... employees. These awards were granted pursuant to the Rigel ... material to the new employees entering into employment with ...
Breaking Medicine Technology: