Navigation Links
Does Glutathione-S-transferase associate with gastrointestinal cancer in Korean population?
Date:12/17/2009

The glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null genotypes have been linked to increased risk of developing cancer. The results regarding the association between GSTM1 and GSTT1 null genotypes and the risk of GC or CRC were contradictory. However, the majority of previous reports are limited by their small sample sizes. Therefore, the association of the GSTM1/GSTT1 null genotype with the risk of GC and CRC need to be confirmed in studies with larger numbers of samples.

A research article to be published on December 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Shin from Chonnam National University Medical School conducted a population-based, large-scale casecontrol study, to evaluate the association of GSTM1 and GSTT1 null genotypes with the risk of gastric and colorectal cancer in a South Korean population.

This is the first investigation of the risk of GC and CRC according to the GSTM1 and GSTT1 null genotypes in a large Korean population, and in addition, this study aims to determine whether smoking, alcohol consumption, and age modify the association between these polymorphisms and GC or CRC risk.

They found that GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans. Smoking, alcohol consumption and age did not modify the association. No difference in the frequency of the combined GSTM1 and GSTT1 null genotype was observed between the two cancer groups and controls.

Although there is a profusion of reports on the association of polymorphisms with GC or CRC risk, few of these results have been convincingly replicated. Therefore, large sample size replication studies are required to confirm these associations in the future.


'/>"/>

Contact: Jin-Lei Wang
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Increased distance to physician associated with thicker skin cancer at diagnosis
5. Minorities more likely to have sleep durations associated with increased mortality
6. Income inequality associated with overnourishment and undernourishment in India
7. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc.
8. Mount Sinai & ENT and Allergy Associates, LLP affiliate to fight cancer
9. J.D. Power and Associates Reports: CIGNA HealthCare Recognized for Call Center Customer Satisfaction Excellence For a Second Consecutive Year
10. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
11. Maternal depression and controlling behavior associated with increased stress response in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... (PRWEB) September 19, 2014 There are thousands ... for companionship and intimacy, and there are thousands of younger ... experienced, mature woman. SeekingCougar.com now provides the world's ... dating website caters to older women, and the younger men ... and convenient way for these people to meet each other ...
(Date:9/18/2014)... 19, 2014 When Mary Ann Thompson and Mathieu ... who live in Bali, Indonesia with their son, Isaac, said there ... two met at Mercy College in 2001 when Thompson was an ... was a graduate student at the time, was French and so ... and migrated to the United States when she was 7 years ...
(Date:9/18/2014)... Toronto, ON (PRWEB) September 18, 2014 ... Facial Plastic Surgeon with the American Academy of Facial ... University of Toronto in the Division of Facial Plastic ... his work in facial plastic surgery. , Dr. ... and foremost, he will be presenting on injection techniques ...
(Date:9/18/2014)... (HealthDay News) -- Rising temperatures in the Atlantic Ocean ... shallow waters that are becoming warmer, an expansion that ... report. A study of 40 species along the ... by the invasive and poisonous lionfish, according to researchers ... the University of North Carolina-Wilmington, who published their findings ...
(Date:9/18/2014)... It’s been just a few short weeks ... bunion splint to website visitors, but already the response has ... absolutely delighted. It is perfect and I find it sooo ... THANK YOU FOR LISTENING!!!" Another user compared the original ... used to slip to the end of my toe. Now ...
Breaking Medicine News(10 mins):Health News:Dating Site "SeekingCougar.com" Now Offering Tips for Younger Men Seeking Older Women 2Health News:For The First Time in Over a Decade Mercy College Alumni Marry at College 2Health News:Dr. David A. F. Ellis Has Been Invited to Speak at a Conference of the American Academy of Facial Plastic and Reconstructive Surgery in Orlando, Florida 2Health News:Rising Atlantic Ocean Temperatures Could Pose Threat to Reefs 2Health News:Feedback for the New Bunion Bootie Design Feedback is Already Pouring In, and Bunion Sufferers Love It 2Health News:Feedback for the New Bunion Bootie Design Feedback is Already Pouring In, and Bunion Sufferers Love It 3
... WEDNESDAY, March 9 (HealthDay News) -- A newly identified toxin ... treat pain and disease in humans, scientists report. Spider ... control the flow of ions across cell membranes and play ... diseases. In their research on the venom of the ...
... 9 (HealthDay News) -- What difference does it make if ... millennia? A lot, as it turns out. Losing a few ... differently than those of other mammals. It may also be the ... some other animals, including chimpanzees and mice. It appears that ...
... polite act shows respect. But a new study of a ... a more practical, though unconscious, shared motivation: to reduce the ... and David A. Rosenbaum of Pennsylvania State University, is the ... altruism and motor control. It is to be published in ...
... clear and watery substance that bathes the brain and ... previously realized. Howard Hughes Medical Institute investigator Christopher ... Zappaterra, and their colleagues have discovered that cerebrospinal fluid ... dramatically with age. In the lab, CSF by itself ...
... News) -- Certain types of medical errors are 46 ... than bottom-ranked hospitals, according to a new study. ... 2007 to 2009 and focused on 13 patient safety ... foreign objects left in the body after procedures and ...
... 9, 2011) University of Minnesota researchers are using salmonella ... of U.S. residents each year to do what was ... Center researchers believe salmonella may be a valuable tool in ... such as the liver, spleen, and colon since that,s ...
Cached Medicine News:Health News:Lost DNA May Have Made Us More Human 2Health News:More reasons to be nice: It's less work for everyone 2Health News:Cerebral spinal fluid guides stem cell development in the brain 2Health News:Cerebral spinal fluid guides stem cell development in the brain 3Health News:Hospital Safety Varies Widely Nationwide: Report 2Health News:U of M researchers using salmonella to fight cancer 2
(Date:9/18/2014)... YORK , Sept. 18, 2014 This BCC Research ... share of major players, market growth and size, and opportunities ... trends and revenue through 2018. Patent analysis in the report ... as the U.S., Europe and ... to: - Define and discuss the global medical device technologies ...
(Date:9/18/2014)... and LONDON , Sept. ... for biopharmaceutical companies. Competition for innovation, increasing clinical ... keep up with the fast-changing environment are important ... clinical trials, and clinical trial costs continue to ... recruitment. Studies conducted by industry think ...
(Date:9/18/2014)... , Sept. 18, 2014  Iliad Neurosciences, Inc., ... to diagnosing and treating Autism Spectrum Disorders (ASD) announced ... Agreement with The Research Foundation for The State University ... will provide a new biomarker to identify an abnormality ... to ASD. This biomarker is expected to be available ...
Breaking Medicine Technology:Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Patient Recruitment in Asia Biotech and Pharma Companies 2Patient Recruitment in Asia Biotech and Pharma Companies 3Iliad Neurosciences, Inc. enters into an Exclusive License Agreement with The Research Foundation for The State University of New York 2Iliad Neurosciences, Inc. enters into an Exclusive License Agreement with The Research Foundation for The State University of New York 3
... PRA International, a leading Clinical Research Organization, will exhibit our ... (ESC) annual conference in Stockholm, Sweden from 28 ... booth C18:62, attendees can schedule meetings with our leading expert ... Head of Scientific Affairs at PRA, to learn how PRA ...
... 23 CVS/pharmacy, Boundless Playgrounds, and Pepsi are ... work together to provide all children with the ... environment.  The partnership is part of the Pepsi ... big and small, that can refresh the world. ...
Cached Medicine Technology:PRA International to Exhibit at ESC's Annual Conference 2CVS/pharmacy and Boundless Playgrounds Join the Pepsi Refresh Challenge to Support Children of All Abilities 2CVS/pharmacy and Boundless Playgrounds Join the Pepsi Refresh Challenge to Support Children of All Abilities 3CVS/pharmacy and Boundless Playgrounds Join the Pepsi Refresh Challenge to Support Children of All Abilities 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: