Navigation Links
Does Glutathione-S-transferase associate with gastrointestinal cancer in Korean population?

The glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null genotypes have been linked to increased risk of developing cancer. The results regarding the association between GSTM1 and GSTT1 null genotypes and the risk of GC or CRC were contradictory. However, the majority of previous reports are limited by their small sample sizes. Therefore, the association of the GSTM1/GSTT1 null genotype with the risk of GC and CRC need to be confirmed in studies with larger numbers of samples.

A research article to be published on December 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Shin from Chonnam National University Medical School conducted a population-based, large-scale casecontrol study, to evaluate the association of GSTM1 and GSTT1 null genotypes with the risk of gastric and colorectal cancer in a South Korean population.

This is the first investigation of the risk of GC and CRC according to the GSTM1 and GSTT1 null genotypes in a large Korean population, and in addition, this study aims to determine whether smoking, alcohol consumption, and age modify the association between these polymorphisms and GC or CRC risk.

They found that GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans. Smoking, alcohol consumption and age did not modify the association. No difference in the frequency of the combined GSTM1 and GSTT1 null genotype was observed between the two cancer groups and controls.

Although there is a profusion of reports on the association of polymorphisms with GC or CRC risk, few of these results have been convincingly replicated. Therefore, large sample size replication studies are required to confirm these associations in the future.


Contact: Jin-Lei Wang
World Journal of Gastroenterology

Page: 1

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Increased distance to physician associated with thicker skin cancer at diagnosis
5. Minorities more likely to have sleep durations associated with increased mortality
6. Income inequality associated with overnourishment and undernourishment in India
7. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc.
8. Mount Sinai & ENT and Allergy Associates, LLP affiliate to fight cancer
9. J.D. Power and Associates Reports: CIGNA HealthCare Recognized for Call Center Customer Satisfaction Excellence For a Second Consecutive Year
10. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
11. Maternal depression and controlling behavior associated with increased stress response in infants
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... experience this summer, ushering in a new era of publicly accessible automated technology. ... shuttle, will continue to offer guests an up-close look at the shuttle at ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... and fun atmosphere for Halloween festivities, the Word of Life Christian Church of ... board game, and featuring a giant 1.25 ton pile of candy dubbed “Candy ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... community across the United States to access life-saving information provided directly ... Mesothelioma will consist of three individual conferences in three major cities: Houston, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 Nevro Corp. (NYSE: NVRO ), ... solutions for the treatment of chronic pain, today announced that ... Patent and Trademark Office (USPTO) has denied instituting an ... (the ,102 patent).  --> ... Scientific Corporation filed two petitions challenging the validity of certain ...
(Date:11/30/2015)... SAN FRANCISCO , Nov. 30, 2015 ... and Designers of Things (DoT ) co-located events ... Printing and the Internet of Things, will draw more ... San Jose Convention Center. The events, combined ... their latest technologies. --> ...
(Date:11/30/2015)... and BOCA RATON, Fla. ... for the Commercialization of Public Research (the Institute) ... with KynderMed , a medical device start-up company ... supports new company creation based on publicly-funded research, and ... Florida -based universities and research institutions. ...
Breaking Medicine Technology: