Navigation Links
Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?
Date:4/30/2008

The LOH analysis on sporadic carcinoma by means of microsatellite markers has become an effective way to find allelic deletion regions and then to find candidate tumor suppressor genes. In a previous study, it was found that D1S413 (1q31.1-32.1, 9.8cM) exhibited higher LOH frequencies, which indicated that the region might harbor the putative tumor suppressor gene(s). However, the allelic deletion region contained so many genes that it was inconvenient to continue the gene screening and functional study. Therefore, further LOH scanning with high-density microsatellite markers in the region was found to be necessary to narrow the research scope and select fewer candidate genes in the finite regions for functional research.

This study, performed by Dr. Chong-Zhi Zhou and his colleagues, is described in a research article to be published on March 14, 2008, in the World Journal of Gastroenterology.

They analyzed refined LOH mapping of 1q31.1-32.1 and found a minimal region of frequent deletion located within a 2-cM genomic segment at D1S413-D1S2622 on 1q31.3-32.1.

Then by searching in the databases, they presumed that CSRP1 might be the candidate colorectal carcinoma-related gene in this region.

In the view of the authors, the genetic changes in colorectal carcinogenesis are not fully understood. However, LOH analysis is an effective method to find informative loci and subsequently identify candidate tumor suppressor genes.

This study found the critical and precise deleted region on 1q31.1-32.1 and provided significant data to help reveal the mechanisms of colorectal carcinogenesis.

Further research should carry out microarray-based high-throughput gene screening and should include functional research for finding the potential tumor suppressor gene.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
2. Cold Spring Harbor scientists devise novel, low-cost method of sifting genomes high-value regions
3. Cold Spring Harbor Protocols features innovative methods for embryology research
4. Cold Spring Harbor Laboratory researchers race against time to save Tasmanian devils
5. Cold Spring Harbor Protocols features high-throughput methods for analyzing gene activity
6. Harborview Medical Center Implements Latest Release of the DocuSys Solution to Improve Anesthesia Medication Safety and Documentation
7. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
8. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
9. Study details regulation of vital tumor suppressor gene p53
10. Human C-reactive protein regulates myeloma tumor cell growth and survival
11. Customized virus kills brain tumor stem cells that drive lethal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... Trenton, NJ (PRWEB) , ... September 20, 2017 ... ... and a variety of settings, gather for the National Athletic Trainers’ Association Annual ... displayed and case studies presented. It is also when Athletic Trainers are acknowledged ...
(Date:9/20/2017)... ... September 20, 2017 , ... The Centers for Medicare and Medicaid Services (CMS) ... transition to using only Worksheet S-10 to distribute Disproportionate Share Hospital (DSH) Uncompensated Care ... 60-minute complimentary webinars on October 17, 2017 at 2 P.M. EST and uncover ...
(Date:9/20/2017)... ... September 20, 2017 , ... “The Trials I Face to Receive ... he emotionally pens his aspirations and goals to better one’s life through God. “The ... Green, while searching in all the wrong places, found a love for writing. Green ...
(Date:9/20/2017)... ... September 20, 2017 , ... Ron Norman, CEO ... marketers this week about the value of senior executives, pointed to a quote ... in business has brought us to the present and will lead us into ...
(Date:9/20/2017)... ... September 20, 2017 , ... “They Sang At Her Funeral”: ... a murderer starts revealing the skeletons in their closets. “They Sang At Her Funeral” ... now fifty-six years young and married with five children and twelve grandchildren. Before becoming ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September ... Washington, D.C. offering free MRI brain scans to the public.Where:  ... will be parked at 501 K Street NW, Washington, D.C.What:BTF brings its ...
Breaking Medicine Technology: