Navigation Links
Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?
Date:4/30/2008

The LOH analysis on sporadic carcinoma by means of microsatellite markers has become an effective way to find allelic deletion regions and then to find candidate tumor suppressor genes. In a previous study, it was found that D1S413 (1q31.1-32.1, 9.8cM) exhibited higher LOH frequencies, which indicated that the region might harbor the putative tumor suppressor gene(s). However, the allelic deletion region contained so many genes that it was inconvenient to continue the gene screening and functional study. Therefore, further LOH scanning with high-density microsatellite markers in the region was found to be necessary to narrow the research scope and select fewer candidate genes in the finite regions for functional research.

This study, performed by Dr. Chong-Zhi Zhou and his colleagues, is described in a research article to be published on March 14, 2008, in the World Journal of Gastroenterology.

They analyzed refined LOH mapping of 1q31.1-32.1 and found a minimal region of frequent deletion located within a 2-cM genomic segment at D1S413-D1S2622 on 1q31.3-32.1.

Then by searching in the databases, they presumed that CSRP1 might be the candidate colorectal carcinoma-related gene in this region.

In the view of the authors, the genetic changes in colorectal carcinogenesis are not fully understood. However, LOH analysis is an effective method to find informative loci and subsequently identify candidate tumor suppressor genes.

This study found the critical and precise deleted region on 1q31.1-32.1 and provided significant data to help reveal the mechanisms of colorectal carcinogenesis.

Further research should carry out microarray-based high-throughput gene screening and should include functional research for finding the potential tumor suppressor gene.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
2. Cold Spring Harbor scientists devise novel, low-cost method of sifting genomes high-value regions
3. Cold Spring Harbor Protocols features innovative methods for embryology research
4. Cold Spring Harbor Laboratory researchers race against time to save Tasmanian devils
5. Cold Spring Harbor Protocols features high-throughput methods for analyzing gene activity
6. Harborview Medical Center Implements Latest Release of the DocuSys Solution to Improve Anesthesia Medication Safety and Documentation
7. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
8. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
9. Study details regulation of vital tumor suppressor gene p53
10. Human C-reactive protein regulates myeloma tumor cell growth and survival
11. Customized virus kills brain tumor stem cells that drive lethal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... , ... October 13, 2017 ... ... of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ... on guideline updates for the primary prevention of cardiovascular diseases during the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
Breaking Medicine Technology: