Navigation Links
Doctors' Guide to Cancer Drugs May Need Revising
Date:2/17/2009

Physicians often rely on outdated data when making 'off-label' decisions, study says

MONDAY, Feb. 16 (HealthDay News) -- Doctors may not always have complete or clear information when they prescribe cancer medications for uses beyond what the drugs have been approved for, a new study finds.

According to the report, published in the Feb. 17 online issue of Annals of Internal Medicine, the online and hard-copy resource used by oncologists and pharmacists, known as the compendia, does not always contain clear or updated information on using medications for "off-label" purposes, such as treating diseases other than those approved by the U.S. Food and Drug Administration.

Doctors and pharmacists often rely on the compendia for off-label dosage information, making it an authoritative source, in some instances, when a question arises about whether insurance will cover a drug for off-label use.

But the researchers found a lack of systematic methods to ensure the compendia information is regularly reviewed or updated.

"Oncologists and pharmacists use the compendia to guide choice of drugs for cancer patients that are not FDA-approved for use in that patient's disease -- an example would be bevacizumab, or Avastin, for brain cancer," the study's lead investigator, Dr. Amy Abernethy, an oncologist at Duke University, said in a news release issued by the school. "Bevacizumab is approved for use in diseases such as colorectal and lung cancer; it is not FDA-approved for brain tumors. But we have evidence that suggests it could be effective in this population, including peer-reviewed studies."

Abernethy's team, from the Duke Comprehensive Cancer Center, also found inconsistencies and confusion in how some commonly used compendia presented information and updated it. Some entries, for example, were more detailed than others, and information was presented in different ways for different drugs.

"Our study found that there are some limitations in the way the compendia are currently presented, and there are opportunities to improve the system," Abernethy said. "Determining how to improve it will be the next step for policymakers."

More information

The U.S. Food and Drug Administration has more about prescription drugs.



-- Kevin McKeever



SOURCE: Duke University, news release, Feb. 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many Hospital Patients Cant ID Their Doctors
2. Wanted: Pioneer IVF Babies Bay Area Fertility Doctors Launch National Search for First IVF Babies Born 25 Years Ago
3. Doctors Fear Patients Not Filling Prescriptions
4. Unbelievable Lack Of Marketing Knowledge Forces Doctors To Quit Practice.
5. Doctors of Optometry Cheer Obamas Call to Action on Childrens Vision
6. Consumer Advocates Call on Legislature to Support Governors Ban on Pharmaceutical Gifts to Doctors
7. Study shows that primary care doctors miss opportunities to recommend colon cancer screening
8. Columbia Doctors, the Physicians and Surgeons of Columbia University Select MxSecure, Inc., as Their Medical Transcription Vendor of Choice
9. AOA Doctors of Optometry Partner With FDA and Other Industry Leaders to Develop New Measures to Better Protect Contact Lens Wearers
10. New Web Site Connects Patients with Experienced Doctors
11. Eye Doctors Offer Advice for Viewers on Super Bowl 3D Ads
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Doctors' Guide to Cancer Drugs May Need Revising
(Date:6/23/2017)... ... June 23, 2017 , ... Yesterday, U.S. ... healthcare bill to repeal and replace the Affordable Care Act (ACA). Like the ... significant cuts to Medicaid, a public health insurance program for low-income children, pregnant ...
(Date:6/23/2017)... ... ... Everybody has their own personal preference when it comes to pornography. Some ... don't like it at all. FindaTopDoc took a look at what makes people attracted ... readers a taste of their deepest, darkest fantasies and has the ability to help ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... civil society in 11 countries across the Middle East and South Asia to embark ... of knowledge and ideas with the leading minds in their fields. , For ...
(Date:6/23/2017)... Francisco, CA (PRWEB) , ... June 23, 2017 , ... ... on 26th June, 2017 from 9 am to 3 pm to present to graduate ... The program is an original curriculum project led by The Health Improvement Service ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, ... area with access to asset protection and financial planning services, is teaming up ... improving the lives of children with cancer and other chronic diseases. , The ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... -- Novavax, Inc., (Nasdaq: NVAX ) today announced that ... its RSV F protein recombinant nanoparticle vaccine candidate (RSV F ... in the journal Vaccine (the data ... conferences). The Company previously announced top line results ... RSV F Vaccine with the goal of protecting infants from ...
(Date:6/3/2017)... INDIANAPOLIS , June 3, 2017  Eli ... today announced that results from the Phase 3 ... kinase (CDK)4 & 6 inhibitor, in combination with ... treatment with fulvestrant alone in women with hormone-receptor-positive ... advanced breast cancer who have relapsed or progressed ...
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. (NYSE: ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, in ... Greisch , Hill-Rom,s president and chief executive officer, is scheduled ... live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm . ... of the live event through September 13, 2017. ...
Breaking Medicine Technology: