Navigation Links
Do you want to know another role of ribonucleotide reductase M2?
Date:9/18/2012

Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. In addition, the incidence and mortality rates of colorectal cancer are on the rise. Recently, metabolic genes have received increasing and specific attention due to their potential role in carcinogenesis.

Previous studies have shown that alterations in ribonucleotide reductase (RR) levels may significantly influence the biological properties of cells, including tumor promotion and tumor progression, suggesting that RR may be implicated in tumorigenesis. Recent findings have established that p53R2 suppresses the invasiveness of cancer cells, and its expression is associated with a better survival prognosis for CRC patients; however, the function of RRM2 in CRC is unclear. Here, we demonstrate that RRM2 may play an important role in the development of CRC and may contribute to the response to UV irradiation.

A research article to be published on September 14, 2012 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Lu from Shanghai Minimally Invasive Surgery Center (Ruijin Hospital, Shanghai Jiaotong University School of Medicine) from China investigated the roles of the hRRM2 subunit in colorectal cancer and UV-induced DNA damage repair.

The results showed that RRM2 overexpression was positively correlated with invasion depth, poorly differentiated type, and tumor, node, metastasis stage. The expression of RRM2 in HCT116 cells was down-regulated after transfection, and HCT116 cell proliferation was obviously suppressed. In the invasion test, the number of cells that passed through the chambers in the RRM2-siRNA group was lower than that in the negative control groups. The results suggest that RRM2 overexpression may be associated with colorectal cancer progression. RRM2 silencing by siRNA may inhibit the hyperplasia and invasiveness of colorectal cancer cells, suggesting that RRM2 may play an important role in the
'/>"/>

Contact: Ling-Ling Wen
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Many US schools are unprepared for another pandemic
2. Yet Another Tick-Borne Illness Emerges in U.S.
3. Enzymes implicated in disease processes attack one another instead of harming body proteins
4. NCH CIRP awarded CDC Injury Control Research Center designation, another 5 years
5. Daily Aspirin May Cut Cancer Deaths, Another Study Finds
6. CDC Warns of Another Emerging Tick-Borne Threat
7. Google Rolls Out Another Panda Algorithm Update – Small Businesses Plan for the Future of SEO
8. Another Drug Take-Back Day Scheduled for Saturday
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 Richard Carlson, Managing ... industry leader with over 25 years experience. Mr. ... in the areas related to EDI, B2B Commerce, RFID ... an Editorial Advisory Board member for Pharmaceutical Commerce Magazine ... Blue Fin Group is a management and technology consulting ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Two sisters in ... heart damage. Ilina and Medha Krishen use electronic ... sounds of trouble in breathing patterns or heartbeats. ... in Michigan, wanted to find a way to detect ... pollutants. Using an electronic stethoscope, Ilina recorded one breath ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, ... tightened guidelines for health workers treating Ebola patients, now requiring ... a respirator at all times. The U.S. Centers for ... after two Dallas nurses contracted Ebola while caring for the ... Thomas Eric Duncan. Nina Pham is currently being treated for ...
(Date:10/20/2014)... Pittsburgh, PA (PRWEB) October 20, 2014 ... new, minimally-invasive procedure that enables physicians to repair a ... , The MitraClip system, developed by ... regurgitation (MR), a progressive and life-threatening condition in which ... allowing blood to flow backward from the heart’s left ...
(Date:10/20/2014)... 20, 2014 T.E.N., a technology ... announced today that William H. Murray, renowned author ... ISE® Luminary Leadership Award winner. Presented annually, the ... an outstanding leader and industry practitioner for his ... advancing the information security industry. , Formerly with ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4
... from Boston University School of Medicine (BUSM) have ... share the majority of the same genes with ... dysregulate the expression of circadian genes and those ... ,The circadian factors, including the principal circadian hormone ...
... of the anti-malarial drug hydroxychloroquine may help reduce ... diabetes . ,Type 2 diabetes mellitus ... its prevalence has been increasing. ... inexpensive treatment for an autoimmune disease such as ...
... A Canadian researcher has unearthed the relationship between high ... of circumstances , including among individuals with heart disease. ... Montreal Heart Institute, currently affiliated with the Universite de ... typically suffer chest pain during exercise, and may be ...
... admitted that she fears that an innocent kiss will result in ... she has major trust issues, and that she doesn't just make ... a waste of her time and kisses. ,Clarkson added ... ,"I have major trust issues. I just don't make ...
... looming global shortage of phosphorus can be dealt with by ... of the Institute for Sustainable Futures at the University of ... may finish in about 50 years. She believes that if ... a year is recycled, the danger of running out of ...
... ash and smoke into the air, seen in the ... causing more than 8000 people to be evacuated amid ... ,Officials raised the alert to the highest level on Tuesday ... Maluku, started spitting out flaming material, indicating magma was approaching ...
Cached Medicine News:Health News:Cocaine Exposure can Alter Neuronal Development in Zebrafish 2Health News:Anti-malarial Drug may Help Reduce Risk of Diabetes in Rheumatoid Arthritis Patients 2Health News:Urine is a Rich Source of Phosphorus 2Health News:Envisat Captured Breath of Volcano 2
(Date:10/22/2014)... Oct. 21, 2014 Influenza will affect as many ... the United States as high as ... to spread is from person to person in respiratory droplets ... serve way of death, but kills much fewer people each ... done by human fluids including sweat, saliva, blood and other ...
(Date:10/22/2014)... and AUSTIN, Texas , Oct. ... LLC today announced they have entered into a ... immunotherapies designed to target cancers. PhosImmune ... displayed on the surfaces of tumor cells in ... (PTTs), derived from proteins that play a role ...
(Date:10/22/2014)... SHANGHAI , Oct. 22, 2014   ... and WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... comprehensive genomic profiling to biopharmaceutical companies conducting clinical trials ... Under the terms of the collaboration, Foundation Medicine will ... of Foundation Medicine,s FoundationOne® assay at the WuXi Genome ...
Breaking Medicine Technology:WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5
... Healthy Advice ® Networks, the nation,s ... programs at point-of-care, announces that their partner, MediaForce ... the Food and Drug Administration,s campaign, educating consumers ... relievers. Partnering with MediaForce PR, Healthy Advice ...
... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... meeting of shareholders held in Hong Kong on August 9, ... the re-election of incumbent Class A directors Xiaozhong Liu, Ying ... term. About WuXi PharmaTechWuXi PharmaTech is a ...
Cached Medicine Technology:Healthy Advice® Networks Partners With MediaForce PR to Deliver Public Service Announcements to Educate Consumers About Appropriate Use of Prescription Medications 2Healthy Advice® Networks Partners With MediaForce PR to Deliver Public Service Announcements to Educate Consumers About Appropriate Use of Prescription Medications 3
... is a versatile, low profile, titanium ... Minimal instrumentation needed for implantation. Reduction ... Monosegmental and multisegmental applications. Worldwide market ... implantations. Tested in accordance with AS ...
... The ISOLA/VSP Spine System is a comprehensive ... that can be used for both deformity ... understanding of the spine in 3-dimensions, the ... translation techniques to correctly align and stabilize ...
Transcranial and peripheral vascular doppler system....
One channel transcranial doppler with multigate, emboli detection, monitoring module and tests for hemodynamic evaluation. Looki 1TC is suitable as well for routine diagnosis as for monitoring in ope...
Medicine Products: