Navigation Links
Do you want to know another role of ribonucleotide reductase M2?
Date:9/18/2012

Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. In addition, the incidence and mortality rates of colorectal cancer are on the rise. Recently, metabolic genes have received increasing and specific attention due to their potential role in carcinogenesis.

Previous studies have shown that alterations in ribonucleotide reductase (RR) levels may significantly influence the biological properties of cells, including tumor promotion and tumor progression, suggesting that RR may be implicated in tumorigenesis. Recent findings have established that p53R2 suppresses the invasiveness of cancer cells, and its expression is associated with a better survival prognosis for CRC patients; however, the function of RRM2 in CRC is unclear. Here, we demonstrate that RRM2 may play an important role in the development of CRC and may contribute to the response to UV irradiation.

A research article to be published on September 14, 2012 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Lu from Shanghai Minimally Invasive Surgery Center (Ruijin Hospital, Shanghai Jiaotong University School of Medicine) from China investigated the roles of the hRRM2 subunit in colorectal cancer and UV-induced DNA damage repair.

The results showed that RRM2 overexpression was positively correlated with invasion depth, poorly differentiated type, and tumor, node, metastasis stage. The expression of RRM2 in HCT116 cells was down-regulated after transfection, and HCT116 cell proliferation was obviously suppressed. In the invasion test, the number of cells that passed through the chambers in the RRM2-siRNA group was lower than that in the negative control groups. The results suggest that RRM2 overexpression may be associated with colorectal cancer progression. RRM2 silencing by siRNA may inhibit the hyperplasia and invasiveness of colorectal cancer cells, suggesting that RRM2 may play an important role in the infiltration and metastasis of colorectal cancer, which is a potential therapeutic strategy in colorectal cancer. In addition, RRM2 depletion increased UV sensitivity.

The researchers drew a conclusion that RRM2 may be a facilitating factor in colorectal tumorigenesis and UV-induced DNA damage repair.

Their study suggests that RRM2 silencing may inhibit the hyperplasia and invasiveness of colorectal cancer cells. RRM2 may play an important role in the infiltration and metastasis of colorectal cancer and that suppression of its function could be a potential therapeutic strategy in colorectal cancer.


'/>"/>

Contact: Ling-Ling Wen
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Many US schools are unprepared for another pandemic
2. Yet Another Tick-Borne Illness Emerges in U.S.
3. Enzymes implicated in disease processes attack one another instead of harming body proteins
4. NCH CIRP awarded CDC Injury Control Research Center designation, another 5 years
5. Daily Aspirin May Cut Cancer Deaths, Another Study Finds
6. CDC Warns of Another Emerging Tick-Borne Threat
7. Google Rolls Out Another Panda Algorithm Update – Small Businesses Plan for the Future of SEO
8. Another Drug Take-Back Day Scheduled for Saturday
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 ... ... over 5,100 hot meals to needy individuals and families from eight different sites ... Florida on Thanksgiving Day. Over 1,000 volunteers worked very hard on Thanksgiving morning ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ‘Tis the ... winners of $1,000 each from the National Family Partnership and the Drug Enforcement Administration ... who decorated their homes and the 10 winning schools who decorated their campuses with ...
(Date:11/30/2016)... ... ... "I hate when the mixture of saliva and toothpaste runs down my toothbrush ... N.J. "I thought that there had to be a way to prevent this mess, ... to prevent saliva and toothpaste from running down the brush handle onto the hand ...
(Date:11/30/2016)... CA (PRWEB) , ... November 30, 2016 , ... ... disorder and mental health treatment has announced the opening of a new residential ... treatment for girls with mental health issues such as severe anxiety, depression, bi-polar ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... community that the FDA Binding Guidance goes into effect next month. Sponsors whose ... in the FDA Data Standards Catalog. The current FDA Data Standards Catalog specifies ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- Allergan plc (NYSE: AGN ), a leading ... announced Accelerated Share Repurchase (ASR) Program. Logo - ... , ... announced, the Company entered into a variable tenor ASR arrangement ... $10 billion of its ordinary shares. Approximately 40.5 million shares ...
(Date:11/30/2016)... , Nov 30, 2016 ... "US Market Overview for Neuromodulation, Neurovascular, Neurosurgical and Monitoring Devices ... ... The full report suite on the ... fluid external drainage systems, intracranial pressure monitoring devices, detachable coils, ...
(Date:11/30/2016)... Nov. 30, 2016 Varian Medical Systems (NYSE: ... America,s Most JUST Company in the Healthcare Equipment and ... magazine,s inaugural "JUST 100 List." The rankings are ... surveys ever conducted on attitudes towards corporate behavior, involving ... list ranks U.S companies against their peers within 32 ...
Breaking Medicine Technology: