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Do unruptured brain vessel malformations need preventative surgery?
Date:4/28/2010

red AVM will bleed or if it ever will."

Past research has suggested that the annual risk of hemorrhaging in the brain from unruptured AVMs may be as low as one percent per year especially among those for whom intervention appears feasible. But large and more complex AVMs have higher hemorrhage rates and pose greater technical challenges for intervention, and as a result treatment is deferred for many due to the risks. Age, deep brain location, associated aneurysms, and deep venous drainage add to hemorrhage risk factors.

"We hope that this study will provide high-quality, scientific evidence to guide the often times difficult decision on whether one ought to have preventative treatment," said Chen. "Currently, this decision is largely determined by anecdotal experiences, biases, hopes and fears."

Patients enrolled in the study will be randomly assigned to one of two groups those who will undergo an AVM elimination and those who will only be managed medically. Study participants will be followed for 5-8 years.

The ARUBA study has enrolled over 120 patients and plants to enroll 800 patients from 100 different institutions worldwide. Rush is one of only two Chicago area medical centers participating in the study.

About Brain Arteriovenous Malformations

Arteriovenous malformations of the brain (AVMs) are abnormal tangles of arteries and veins which usually date back to birth, but can also result from head injury. Brain AVMs can occur in any part of the brain and what causes them is not clear.

Normally, blood from the heart moves from the arteries to the veins through a fine network of small blood vessels called a capillary bed. In an individual with a brain AVM, the arteries and veins are connected directly without a capillary bed, exposing the thin-walled veins to high pressure that increase risk for rupturing and bleeding into the brain.

You may not know you have an AVM until you exp
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Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

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