Navigation Links
Do probiotics help kids with stomach bugs?
Date:7/3/2014

Consumers worldwide spend billions of dollars each year on probiotic foods and supplements. But studies evaluating probiotics microorganisms believed to aid digestive health have been limited.

To better understand probiotics' capabilities, researchers at Washington University School of Medicine in St. Louis are leading a nationwide clinical trial to determine whether one of the most commonly used probiotics can safely and effectively treat infants and toddlers suffering from acute gastroenteritis, otherwise known as stomach virus or "stomach flu."

"Probiotics are very popular," said David Schnadower, MD, the trial's principal investigator and an associate professor of pediatrics at the School of Medicine. "People use them for everything, especially diarrhea, yet minimal data exist showing they really help. There is a real need to do a clear, definitive study of the use of probiotics in kids with gastroenteritis."

Probiotics are live microorganisms used to restore the balance of intestinal bacteria and increase resistance to harmful germs. They are added to yogurt, drinks and other foods and also are sold over the counter in pill and powder form.

While medical professionals sometimes give children with gastroenteritis medication to treat nausea and fluids to prevent dehydration, there are currently no treatments for the condition.

"We hope to provide evidence for or against the use of probiotics in children with stomach viruses," said Schnadower, who also treats patients at St. Louis Children's Hospital. "If the probiotic we are studying is helpful, safe and cost-effective, then I can foresee doctors prescribing it to children with diarrhea and other symptoms of gastroenteritis. But what we don't want is for the use of probiotics to become a practice that is not supported by evidence."

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH) is funding the trial with a five-year $3.6 million grant.

The trial will involve about 900 children, ages 3 months to 48 months, treated at St. Louis Children's and at eight other academic medical centers.

Participants may be eligible if they come to the emergency room with symptoms of gastroenteritis: watery stools, vomiting, dehydration or other signs of acute intestinal infection. They also must not have taken probiotics in the preceding two weeks and must meet other criteria.

Children will be randomly assigned to receive a probiotic or a placebo for five days. The probiotic, approved by the Food and Drug Administration, is Lactobacillus GG, or LGG, which is sold over the counter as Culturelle. Otherwise, children in the trial will receive standard clinical care.

Researchers will assess patients by tracking the severity of their gastroenteritis, taking into account the duration and frequency of diarrhea and vomiting, the duration and height of fever, and the use of health-care resources such as doctor or hospital visits and use of intravenous rehydration.

For the first five days after an emergency room visit and again at two weeks, researchers will monitor patients via symptom diaries and phone or Internet surveys. The researchers will follow up with parents at the one-, three-, six-, nine- and 12-month marks after the initial emergency room visit, to check on each child's health.

Evidence-based medicine can be an elusive goal," said co-investigator Phillip I. Tarr, MD, the Melvin E. Carnahan Professor of Pediatrics at the School of Medicine. "It is terrific that David and his emergency medicine collaborators are trying to gather high-quality data on which to base our treatment decisions."

Schnadower said investigators also will examine the impact, if any, that probiotics have on household transmission of diarrhea and a range of economic data involving missed work, missed day care and even the cost of diapers.

Collaborators in the trial are Columbia University in New York, Northwestern University in Chicago, Children's National Medical Center in Washington, Children's Hospital of Michigan in Detroit, Cincinnati Children's Hospital Medical Center, Brown University in Providence, R.I., University of Michigan in Ann Arbor and UC Davis Children's Hospital in Sacramento, Calif. The trial is conducted under the auspices of the Pediatric Emergency Care Applied Research Network, and the data center is at the University of Utah.

A similar trial in Canada examining the safety and efficacy of another common probiotic Lacidofil will coincide with the U.S. study. That trial, funded by the Canadian Institutes of Health Research, also will involve young children with gastroenteritis.

"Not only will we be able to know whether one probiotic is effective versus placebo, we also likely will be able to combine our data and learn whether one probiotic is more effective," Schnadower said.


'/>"/>

Contact: Elizabethe Holland Durando
elizabethe.durando@wustl.edu
314-286-0119
Washington University School of Medicine
Source:Eurekalert  

Related medicine news :

1. Certain probiotics could help women lose weight
2. Proactive Use of Florastor Probiotics Make for Happy, Healthy Holidays
3. International Probiotics Association Opens Registration for 2014 World Congress in Athen's Greece
4. Probiotics reduce piglet pathogens
5. Are probiotics a promising treatment strategy for depression?
6. Probiotics Market (Functional Foods, Dietary Supplements, Specialty Nutrients, Animal Feed) Worth $23.93 Billion by 2017 - New Report by MarketsandMarkets
7. Probiotics Reduce Severity and Duration of Common Cold by 27% - Article and Video Published by Health News Wires
8. Probiotics Market (Functional Foods, Dietary Supplements, Specialty Nutrients, Animal Feed) Worth $23.93 Billion by 2017 - New Report by MarketsandMarkets
9. International Probiotics Association Objects to Media Depiction of AAD/CDD Study, Provides Further Insight to Study Results
10. Probiotics do not prevent relapse in Crohns disease patients
11. Probiotics and Exercise for Anxiety and Stress Reduction Article and Video Released by Health News Wires
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Do probiotics help kids with stomach bugs?
(Date:3/28/2017)... ... March 28, 2017 , ... ... by the American Association of Integrative Medicine and available for application on Saturday, ... the AutismOne 2017 Conference in Colorado Springs. , Ed Arranga, president of AutismOne, ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Lice Treatment Center® ... March 13-16, was a busy spot this year. Liz Solovay and Adrian Picheny, ... preventing outbreaks among camp communities during the upcoming 2017 camping season. “Lice infestations ...
(Date:3/28/2017)... ... March 28, 2017 , ... Oily skin is a common and unwelcomed occurrence in people ... has a lot to offer to the discussion of dealing with excess skin oil. “Oily ... are many home remedies that can help remove the oily shine while keeping the skin ...
(Date:3/28/2017)... ... ... adventure that reveals the mystery of Kevin’s purpose. “A Prophets Bones” is the creation of ... of him that he had neglected to do, but this was from God and there ... who would have felt themselves to be special and better than others due to the ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... for clear braces. People who want straight teeth without the extensive time commitment ... in Clearwater, FL, without acquiring a referral. A custom-designed series of virtually invisible ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... YORK , March 28, 2017 ... investors, attention to these four stocks: The Medicines ... Pacira Pharmaceuticals Inc. (NASDAQ: PCRX), and Supernus Pharmaceuticals ... operate in the Generic Drugs space which is ... drugs. The key growth drivers for the industry are ...
(Date:3/28/2017)... ROCKVILLE, Md. , March 28, 2017 /PRNewswire/ ... dedicated to innovative therapeutics addressing cancer and other ... at the American Association for Cancer Research annual ... April 3 is entitled "Evaluation of ENMD-2076 ... and the second poster to be presented ...
(Date:3/28/2017)... , March 28, 2017  Medeon Biodesign, Inc., ... company, is pleased to announce that the Company ... of Panther Orthopedics, Inc., a San ... fixation solutions for orthopedic extremity applications.  ... expand rapidly, primarily due to procedure volume growth, ...
Breaking Medicine Technology: