Navigation Links
Do patients at risk for B-cell malignancy need antiviral treatment?
Date:4/15/2009

Some studies have shown that a relationship of hepatitis C (HCV) infection with type II mixed cryoglobulinemia exists. However the precise mechanism remains unclear.

A research article to be published on April 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Fan from the Department of Infectious Disease of the People's Liberation Army 161 Hospital in Wuhan used IgH rearrangement and immunohistochemistry. Various research studies indicated a relationship between the B-cell clonality with non-Hodgkin lymphoma, and this article further investigates the risk for developing malignant lymphoproliferative disease in the HCV-infected patients with B-cell clonality in the liver.

Liver-infiltrating monoclonal B-cells were detected in the liver of 4 (10%) of 40 HCV-positive patients but were present in only 3 (0.37%) of 808 liver biopsy specimens with chronic HBV infection. Chi-square tesing showed the monoclonal B-cells infiltrating in the liver were more frequent in the HCV-infected patients (P=0.000).A clonal IgH rearrangement was detected in 5 (71.4%) of 7 liver biopsy specimens with monoclonal B-cells infiltration. In 2 of 5 patients with both a clonal B-cell expansion and monoclonal B-cells infiltration in the liver, a definite B-cell malignancy was finally diagnosed.

Recent reports have highlighted the importance of antiviral treatment in the HCV-infected patient with B-cell clonality in the liver. This is the first study to analyze the association of monoclonal B-cells infiltrating in the liver with the B-cell clonality. Furthermore, our follow up study showed that lymphoma developed more frequently in the patients who had monoclonal B-cells infiltration and B-cell proliferation in the liver. The presence of a B-cell clonality and monoclonal B-cells infiltrating in the liver may be useful for detecting patients at high risk for developing malignant lymphoproliferative disease. The study results suggest a strategy for antiviral treatment in patients at risk for B-cell malignancy.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Tourette syndrome misconceptions only one battle for patients
2. Study suggests that trouble sleeping leads to increased ratings of pain in cancer patients
3. Study Finds Discontinuation of Rosiglitazone Left Many Diabetes Patients Without Good Glycemic Control
4. Heart screening unnecessary in type 2 diabetes patients with no symptoms
5. Low Blood Sugar Events Increase Dementia Risk in Elderly Patients With Type 2 Diabetes, Kaiser Permanente Study Finds
6. Are Herbal Supplements Putting Aesthetic Surgery Patients at Risk?
7. Patients Beyond Borders Malaysia Edition to Launch in July
8. Six-Minute Surgical Instrument Sterilizer to Protect Patients and Save Hospitals $Billions
9. Improved Care for Kidney Patients Reduces Medicare Costs and Saves Taxpayers Money
10. Omega-3 fatty acids may benefit cancer patients undergoing major operations
11. A Decision Beyond Life and Death: Novel Examines Effects of Controversial Procedure on Patients, Their Families and Doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... Camas, WA (PRWEB) , ... ... ... Agencies, a full service insurance provider serving families of Camas and Vancouver, ... The current campaign fundraises for the National Breast Cancer Foundation and their ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... wellness and sleep disorder management, today announced it has secured $9 million in ... (WiL) and existing investors. The investment will be used by Somnoware to further ...
(Date:5/4/2016)... ... May 04, 2016 , ... Level 10 Head Over Heels Athletic ... to the University of Arizona for the fall of 2019. , After a ... Brovedani’s commitment to the GymCats came from her connection with the coaching staff and ...
(Date:5/4/2016)... York, NY (PRWEB) , ... May 04, 2016 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – is set to return to the esteemed Quaker Ridge Golf Club ...
(Date:5/4/2016)... Boston, MA (PRWEB) , ... May 04, 2016 ... ... to help fund Dr. Todd Rider's research and development of DRACO broad-spectrum antiviral ... experiments. In the campaign that starts on May 3, 2016 at http://igg.me/at/EndTheVirus ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016 According to a ... Computer Interface Market - Global Industry Analysis, Size, Share, ... computer interface (BCI) market  is expected to reach a ... estimated to expand at a CAGR of 14.9 % ... A BCI device provides collaboration between the brain ...
(Date:5/4/2016)... upgrade. There are many medical recorders on the market but none like this. Through ...  offers unparalleled connectivity and functionality.  Ampronix  is a renowned authorized reseller of the medical ... Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
(Date:5/4/2016)... ZIONA, Israel , May 4, 2016 /PRNewswire/ ... announced today that BiondVax,s CEO, Dr. Ron Babecoff , ... New York City . On ... at Pioneers 2016, a conference presented by Joseph Gunner ... Hotel. The BiondVax presentation that Dr. Babecoff will ...
Breaking Medicine Technology: