Navigation Links
Do non-steroidal anti-inflammatory drugs cause kidney failure in children?
Date:1/24/2013

Cincinnati, OH, January 25, 2013 -- Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are commonly used to treat pain and reduce fever in children. However, the use of NSAIDs has been shown to cause acute kidney injury (AKI) in some children. A new study scheduled for publication in The Journal of Pediatrics reports the findings on the number of children diagnosed with AKI caused by NSAIDs in one hospital over an 11 year span.

Dr. Jason Misurac and colleagues from the Indiana University School of Medicine and Butler University retrospectively screened all patients hospitalized at Riley Hospital for Children at IU Health who were identified with AKI. Out of 1015 patients with AKI, 27 were identified to have NSAID-associated AKI. Seventy-eight percent of the 27 patients had been using NSAIDs for less than 7 days, and 75% took the medication at the correct dosage. In 67% of the cases, the family reported that the child had signs of dehydration. Most of the patients were teens; however, patients who were less than 5 years old were more seriously affected and more likely to need dialysis. Although the reasons for younger children having a more severe disease course are unknown, the authors speculate that it could be due to an increased susceptibility to the toxic effects of NSAIDs. None of the patients died or developed permanent kidney failure, but 30% of the children had evidence of mild chronic kidney damage persisting after recovery from the episode of AKI.

The costs of caring for children with NSAID-associated AKI are significant, especially considering that this is an avoidable condition. Adding to this cost burden is the long-term care needed, because studies show that these patients have an increased risk of progressive chronic kidney disease. In some cases, acetaminophen might be a more appropriate choice for treatment. "This study underscores the importance of understanding the natural history of NSAID-associated AKI, including the potential for development of chronic kidney disease," notes Dr. Misurac. "Providers should continue to provide careful NSAID education to parents and children."


'/>"/>
Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Multi-functional anti-inflammatory/anti-allergic developed by Hebrew University researcher
2. NIH launches trial to evaluate anti-inflammatory treatment for preventing heart attacks, strokes, and cardiovascular deaths
3. New anti-inflammatory drugs pinch off reactive oxygen species at the source
4. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
5. Research: Lupus drugs carry no significant cancer risk for patients
6. Hearing-loss-prevention drugs closer to reality thanks to new UF test
7. Scientists find a new way to boost common cancer drugs
8. UGA discovery promises to improve drugs used to fight cancer, other diseases
9. Which Hospital Patients Need Drugs to Prevent Gastrointestinal Bleeding?
10. Helping patients navigate new cancer drugs
11. 1/3 of Docs Often Prescribe Brand-Name Drugs Over Generics: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... KS (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com ... retailers of Eyeglasses . , Millions of individuals in the United States and ... have become a way to both correct vision and make a fashion statement. Even ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: