Navigation Links
Do bacterial combinations result in enhanced cytokine production? No!
Date:3/18/2008

Probiotic bacteria, defined as living microorganisms that have beneficial effects on human health, have been used for the prevention and treatment of a diverse range of disorders. However, the ways in which probiotic bacteria elicit their health effects are not fully understood. One of the action mechanisms could be the ability to induce cytokines that further regulate innate and adaptive immune responses. At present there is only a limited amount of comparative data available on the ability of different probiotic strains to induce cytokine responses within the same experimental system. In addition, the effect of probiotic bacterial combinations on cytokine production in vitro is not well documented although bacterial combinations have been used in many clinical trials.

A recent study revealed that probiotic bacteria seem to direct immune responses to either a Th1 type or in anti-inflammatory way in a bacterial genera-specific manner in human leukocyte cell culture. Not all bacterial combinations resulted in enhanced cytokine production suggesting that different bacteria -- whether gram-positive or gram-negative -- compete with each other during host cell interactions. Results of this study can be exploited for designing new probiotic products that have specific health effects.

This study, performed by the groups of Dr Korpela and Professor Julkunen and to be published in February 28, 2008 in issue 8 of the World Journal of Gastroenterology. The work was carried out in collaboration with National Public Health Institute (Finland), Valio Research Centre (Finland) and University of Helsinki (Finland).

This is one of the few studies that have compared the cytokine patterns of probiotic bacteria and their combinations within the same experimental setting. It was found that probiotic bacteria induce differential cytokine responses dependent on the bacterial genera. In addition it was found that novel probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN- than the probiotic Lactobacillus strains presently in use in probiotic products. The use of bacterial combinations did not result in enhanced cytokine production.

More detailed information on the cytokine patterns elicited by probiotic bacteria may help in designing probiotics for specific preventative or therapeutic purposes.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Antibacterial Soap Claims Just Dont Wash
2. New viruses to treat bacterial diseases -- My enemies enemy is my friend
3. Early Bacterial Infection May Boost Asthma Risk
4. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
5. Antibacterial chemical disrupts hormone activities
6. Breath test can discriminate between a bacterial overgrowth and IBS
7. First look at an enzyme target for antibacterial and cancer drugs
8. Forsyth launches 1-of-a-kind core service to enable rapid identification of bacterial samples
9. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
10. Bacterial toxin closes gate on immune response, Penn researchers discover
11. Why recovery from flu may increase odds of bacterial infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Cut Pro X users can now reveal the media of their split screens ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: