Navigation Links
Diving deeper into the gene pool
Date:9/27/2010

About ten years ago, the discovery of microRNAs ― tiny cellular molecules that regulate our genetic code ― unlocked a world of scientific possibilities, including a deeper understanding of human disease. One new analytical technology is "deep sequencing," which gives scientists the ability to discover invaluable information about human diseases at a genetic level. Now, Tel Aviv University researchers have developed the cutting-edge technology to better analyze these results.

The software, called miRNAkey, was developed by Roy Ronen as part of a team of researchers headed by Dr. Noam Shomron of the Sackler Faculty of Medicine. Dr. Shomron says that miRNAkey searches for microRNA patterns in both healthy and diseased tissues, improving scientists' understanding of the data collected from deep sequencing technology.

The software package was recently described in the journal Bioinformatics.

Making sense of microRNA patterns

Deep sequencing is used to determine the ultimate sequence and expression of cellular DNA or RNA. Once these molecules are extracted, scientists must be able to read the valuable information that the data supplies. Among these are the entire human genome sequence, the expression of the genes from the genome, and the molecules, such as microRNA, which regulate genetic expression. In short, it allows biologists to see further into human genetics and determine where and when genetic malfunctions might occur.

Until now there were very few unified codes that could interpret what information the microRNA held, and none that could run on a local computer or explain ambiguous microRNA behaviors. The solution is the miRNAkey program, says Dr. Shomron. It is designed to identify the relevant microRNA molecule, determine its level, then generate statistically valuable information from it.

"Such identification of microRNAs allows us to manipulate them," Dr. Shomron explains. One example of this potential manipulation is the alteration of malignant tumors. In one study Dr. Shomron and his team of researchers were able to identify the relevant microRNA molecules in an aggressive malignant form of cancer. They then inserted the healthy, non-aggressive form of these microRNAs into the diseased, aggressive molecule. In an animal model, this resulted in a significant slowing of tumor growth.

Results right to the computer screen

With his software, says Dr. Shomron, data obtained from deep sequencing can be quickly and correctly analyzed, allowing scientists to take a deeper look into disease behavior and potentially build specialized treatments with this knowledge. It may also encourage the creation of "smart drugs" which target individual damaged cells.

With a user-friendly interface, miRNAkey can be used on any local computer alongside the proper deep sequencing technology. Unique features such as data statistics and detailed reports provide valuable information about extracted microRNA, notes Dr. Shomron.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards luncheon ... editorial and design excellence across a range of sectors. This year’s program included the ...
(Date:10/12/2017)... Wesley Chapel, FL (PRWEB) , ... October 12, 2017 , ... ... Chapel is holding a treadmill relay – Miles by Moonlight to raise money for ... by donating $300 or more. , Teams will work together to keep their ...
(Date:10/12/2017)... ... , ... Health Literacy Innovations (HLI), creator of the Health ... Cancer Patient Education Network (CPEN), an independent professional organization that shares best practices ... , As CPEN’s strategic partner, HLI will help support CPEN members by ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated ... latest FDA requirements, which stipulates new criteria regarding medical device manufacture ... Medical ID jewelry such as Medical ID Bracelets, can rest assured ... of the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process ...
(Date:10/11/2017)... 11, 2017  Caris Life Sciences ® , a ... promise of precision medicine, today announced that St. Jude ... Oncology Alliance™ (POA) as its 17 th member. ... Jude Crosson Cancer Institute will help develop standards of ... tumor profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology: