Navigation Links
Diverse gut bacteria associated with favorable ratio of estrogen metabolites
Date:9/11/2014

Washington, DCPostmenopausal women with diverse gut bacteria exhibit a more favorable ratio of estrogen metabolites, which is associated with reduced risk for breast cancer, compared to women with less microbial variation, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Since the 1970s, it has been known that in addition to supporting digestion, the intestinal bacteria that make up the gut microbiome influence how women's bodies process estrogen, the primary female sex hormone. The colonies of bacteria determine whether estrogen and the fragments left behind after the hormone is processed continue circulating through the body or are expelled through urine and feces. Previous studies have shown that levels of estrogen and estrogen metabolites circulating in the body are associated with risk of developing postmenopausal breast cancer.

"In women who had more diverse communities of gut bacteria, higher levels of estrogen fragments were left after the body metabolized the hormone, compared to women with less diverse intestinal bacteria," said one of the study's authors, James Goedert, MD, of the National Institutes of Health's National Cancer Institute (NCI) in Bethesda, MD. "This pattern suggests that these women may have a lower risk of developing breast cancer."

As part of the cross-sectional study, researchers analyzed fecal and urine samples from 60 postmenopausal women enrolled in Kaiser Permanente Colorado. The women were between the ages of 55 and 69, and all participants had a mammogram with normal results in the previous six to eight weeks. The samples were analyzed for bacterial diversity and the ratio of estrogen fragments to estrogen, a predictor of breast cancer risk.

"Our findings suggest a relationship between the diversity of the bacterial community in the gut, which theoretically can be altered with changes in diet or some medications, and future risk of developing breast cancer," Goedert said. "Findings from this proof-of-principle study need to be replicated in larger groups of women. But we are hopeful that because the microbiome can change the way the body processes estrogens, it may one day offer a target for breast cancer prevention."


'/>"/>

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society
@EndoMedia
Source:Eurekalert

Related medicine news :

1. The Fenway Institute study finds that diverse group of patients willing to answer questions about sexual orientation and gender identity in health care settings
2. New Hindu Chaplain Complements Oakwood’s Diverse Embrace of All Major Faiths - Ambassadors of Peace to Host Interfaith Prayer Service on Aug. 14
3. Who should be saved? Study gets diverse MD community views on healthcare disaster planning
4. National Alliance For Hispanic Health Leads Diverse “Friends of the Court” in Support of NYC Policy to Reduce Sugary Drink Portion Size
5. Clinical sequencing technology identifies new targets in diverse cancers
6. Diva Diverse: New Dance Studio in Scarborough
7. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
8. $2.8M grant gives diverse students a healing opportunity
9. New research uncovers diverse metabolic roles for PML tumor suppressor gene
10. Antibacterial Drugs Market: News and Analysis by Transparency Market Research
11. UTHealth researchers find up to 3,000 times the bacterial growth on hollow-head toothbrushes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2018)... ... November 15, 2018 , ... ... four more skilled medical professionals to join their team at Waldman, ... its skin clinic, Skin Chic, and is expanding its staff to meet patient ...
(Date:11/15/2018)... ... 2018 , ... The National Cancer Institute estimates that 1.7 million new cases ... factor for cancer and we typically associate the disease with old age, about 9 ... aggressive treatment and advanced therapies, increasing numbers of these patients survive their disease and ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... ... has been designated as a UroLift® Center of Excellence. The designation recognizes that ... UroLift System and demonstrated a commitment to exemplary care for men suffering from ...
(Date:11/14/2018)... ... November 14, 2018 , ... Acti-Kare of Beebe, AR , ... Ward and Romance, is celebrating its official grand opening with a ribbon cutting ceremony ... to like and follow the Acti-Kare Facebook page to participate in all ...
(Date:11/14/2018)... ... 14, 2018 , ... Contrary to what most people think, ... batteries hold the honor at a whopping 99.3 percent, according to the Environmental ... 15, the lead battery industry is proudly sharing the impressive sustainability story of ...
Breaking Medicine News(10 mins):
(Date:11/15/2018)... ... November 15, 2018 , ... ... health records (EHR) technology for acute care, post-acute care, and long-term care facilities ... innovative strategies to help healthcare professionals provide more efficient and effective patient care. ...
(Date:11/15/2018)... ... November 15, 2018 , ... PhyMed Healthcare ... completed a transaction with Grand Canyon Anesthesia (“GCA”), a Phoenix-based anesthesiology practice organization. ... in the Phoenix area,” says Marty Bonick, chief executive officer of PhyMed. “Fueled ...
(Date:11/15/2018)... ... November 15, 2018 , ... Joint Implant Surgeons (JIS) , ... Midwest, is one of only nine group practice centers in the nation to be ... common surgeries Americans undergo each year—knee and hip replacement—will be transformed by the Zimmer ...
Breaking Medicine Technology: