Navigation Links
Diuretics Still Best Treatment for High Blood Pressure
Date:11/18/2009

Long-term comparison study finds chlorthalidone most likely to prevent heart failure, stroke

WEDNESDAY, Nov. 18 (HealthDay News) -- Tried-and-true diuretics maintain their status as the best first-line treatment in older men and women with high blood pressure, new research concludes.

The thiazide-type diuretic chlorthalidone outshone three other treatments -- a calcium channel blocker, an ACE inhibitor and an alpha-receptor blocker -- in most areas, especially in lowering the incidence of stroke and heart failure, according to the most current data from a large ongoing study known as ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).

"We believe thiazide-type diuretics should still be preferred," said study investigator Dr. William Cushman, professor and chief of preventive medicine at the Veterans Affairs Medical Center in Memphis, Tenn., at a news conference on the findings Wednesday at the annual meeting of the American Heart Association (AHA) in Orlando, Fla.

"The message is largely unchanged, and the main message is that treating hypertension [high blood pressure] is very necessary," added Dr. Clyde Yancy, president of the AHA. "Treating hypertension with chlorthalidone resulted in a significant reduction in heart failure and stroke."

The original trial, begun in 1994, involved more than 42,000 patients with hypertension and at least one other risk factor for cardiovascular disease. The participants were randomly assigned to take one of the following anti-hypertensive drugs: chlorthalidone (the diuretic), amlodipine besylate (the calcium channel blocker), doxazosin mesylate (the alpha blocker) or lisinopril (an ACE inhibitor).

The five-year follow-up, which ended in 2002, was intended to see if new differences emerged with long-term use of the medications, especially regarding coronary heart disease, total mortality, heart failure and aggregate cardiovascular disease.

"This is the largest hypertension trial to date," Cushman said.

Earlier results from ALLHAT had also found that diuretics were as good or better than other blood pressure-lowering drugs for treating hypertension in patients with metabolic syndrome (a collection of factors that put people at risk of heart disease), especially black patients.

"None of the newer drugs were superior to chlorthalidone for reducing death from cardiovascular disease or end-stage renal disease, although the calcium channel blocker was very similar," Cushman stated.

Strokes were much more common in black study participants taking the newer drugs, and patients on the calcium channel blocker had much higher rates of heart failure.

Cushman also presented some 10-year follow-up data, which were essentially the same as the five-year data. No new adverse events cropped up, he noted.

"Chlorthalidone treatment is superior to each in preventing one or more major cardiovascular events as long as participants continued taking the drug," he said.

More information

The American Heart Association has more on high blood pressure.



SOURCES: Nov. 18, 2009, news conference with William Cushman, M.D., professor and chief of preventive medicine, Veterans Affairs Medical Center, Memphis, Tenn.; Clyde Yancy, M.D., president, American Heart Association; Nov. 18, 2009, presentation, American Heart Association annual meeting, Orlando, Fla.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood Pressure Pill Combo More Effective Than Diuretics
2. Diuretics excel in drug comparison trial involving hypertension/metabolic syndrome
3. Diuretics Best for Hypertension and Metabolic Syndrome
4. Doc Fix NOT What The Doctor Ordered; National Physician Group OPPOSES Pay Raise in House; Failed in Senate, Still a Bad Idea in the House; Payoff to AMA? New Survey Shows Money is Not Primary Concern of Doctors
5. LTC Awareness Month Finds Americans Still in Dark about Long-Term Care
6. Father Norman Weslin and Four Pro-Lifers Still in Jail.
7. Life Saving Estill Medical Technologies Receives Prestigious Dallas 100(TM) Award
8. Practical Nursing Still a Growth Area in BC
9. Antibiotic Resistance Still a Major Public Health Threat
10. Lying Still Raises Artificial Insemination Success
11. Laying Still Raises Artificial Insemination Success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical ... in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the ... products in action, learn more about their chosen field and network with their colleagues. ...
(Date:2/12/2016)... Atlanta, GA (PRWEB) , ... February 12, 2016 ... ... and relationship-marketing firm announced that nominations have closed for the ISE Southeast Awards ... categories will be announced at the ISE® Southeast Executive Forum and Awards Gala ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... ... The Jones Agency, a family owned insurance company with offices serving Arlington, Dallas, ... with the Tarrant Area Food Bank in the hopes of alleviating hunger for nearby ... Tarrant County Food Bank offers hope and security to the one in six Texas ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a full ... of the latest charity campaign in their community enrichment program. Art Expression utilizes ... worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- The primary goal of this research is to ... usage of liquid biopsy. Key information the survey seeks ... of liquid biopsy adoption amidst future users - Predominantly ... - Sample inflow to conduct liquid biopsy tests - ... so on. - Correlation analysis of sample type and ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
(Date:2/11/2016)... Feb. 11, 2016 Potrero Medical, Inc., the developer ... announce the appointment of George M. Rapier, III , ... Antonio, TX , WellMed is one of the nation,s ... and HMO members in Texas and ... out of his own internal medicine practice, he has been ...
Breaking Medicine Technology: