Navigation Links
Disorderly enzyme is key for antibody diversity
Date:6/27/2011

sequences comprising three bases found along the DNA.

Unlike most enzymes that are exquisitely efficient in targeting favored motifs, they found that AID was extremely inefficient. AID initiated chemical reactions in favored motifs only about 3 percent of the time. By mutating the motifs so haphazardly, the researchers suggest that AID produces antibody diversity.

The study also sheds light on a little-studied group of enzymes. Enzymes such as AID that scan single-stranded DNA have been studied far less extensively than enzymes that scan double-stranded DNA.

"This is the first really clear picture of what AID is doing during the scanning process," Goodman said.

To identify and describe AID's complex process during scanning, the team used a genetic assay to measure the distribution of AID-induced mutations on individual DNA molecules and then analyzed the mutational data computationally using a random walk model, developed for the study by USC Dornsife researcher Peter Calabrese. By combining the genetic and computational analyses, they were able to calculate the distribution of mutations that occurred with a remarkable fit to their experimental data. The fit entailed matching theory to experiment for the patterns of closely spaced mutations and separately for the distances between mutated and non-mutated target motifs.


'/>"/>

Contact: Michelle Salzman
msalzman@dornsife.usc.edu
213-821-9311
University of Southern California
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada
2. Enzyme may drive breast cancer growth
3. Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
4. The TET1 enzyme steers us through fetal development and fights cancer
5. Investigators discover enzyme essential for healthy lung development
6. Newly discovered role for enzyme in neurodegenerative diseases
7. Enzyme helps prepare lung tissue for metastatic development
8. Heart Enzymes May Predict Outcome After Bypass Surgery
9. Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
10. Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
11. Chaperone enzyme provides new target for cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... medical-testing device is being prepped to enter the ... diagnosis of certain diseases in remote areas, thanks ... of investigations aboard the International Space Station on ... space-tested concept of capillary flow to diagnose infectious ... Kelso, Ph.D., a researcher at Northwestern University in ...
(Date:4/18/2014)... What,s one of your worst memories? How did it ... felt during a negative personal experience, such as how ... lead to emotional distress, especially when you can,t stop ... creep up, thinking about the context of the memories, ... and effective way to alleviate the negative effects of ...
(Date:4/18/2014)... in French . ... and regenerative medicine. A team led by Ludwik Leibler ... Tech) and Didier Letourneur from the Laboratoire Recherche Vasculaire ... demonstrated that the principle of adhesion by aqueous solutions ... soft-tissue organs and tissues. This easy-to-use gluing method has ...
(Date:4/17/2014)... genetic variant specifically associated with the risk of ... per cent of all breast cancer cases. , ... sub-type, called invasive lobular carcinoma, gives researchers important ... kind of breast cancer, which can be missed ... in the journal PloS Genetics , was ...
(Date:4/17/2014)... In the April issue of Experimental Biology ... by Drs. Rex Gaskins and Paul Kenis in ... campus of the University of Illinois Urbana-Champaign describe ... reduction-oxidation reactions underlie a variety of cell functions ... to these crucial roles in regulating normal cellular ...
Breaking Medicine News(10 mins):Health News:Space-tested fluid flow concept advances infectious disease diagnoses 2Health News:Space-tested fluid flow concept advances infectious disease diagnoses 3Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2
... Solta Medical, Inc. (Nasdaq: SLTM ), ... announced that it has received regulatory clearance to market ... excited about the opportunity to market the premier non-invasive ... Republic of China," said Stephen J. Fanning, Chairman of ...
... ProMetic Life Sciences Inc. (TSX: PLI ... announces that it has retained the services of ... subsidiaries of Sumitomo Corporation ("Sumitomo") to advise ProMetic in ... Japanese market.In the course of ProMetic,s partnering activities several ...
... that can cause anal and cervical cancers, is associated with ... men who have sex with men (MSM), according to new ... journal AIDS , the findings are available now. ... , In previous studies, other sexually transmitted infections have been ...
... Wolff today assured Pennsylvanians that the 2009 H1N1 influenza strain ... anywhere in either the U.S. or Mexico, and that pork ... as the ,swine flu, many misconceptions relating to pigs have ... and living near or working on a hog farm is ...
... 30 The Alzheimer,s Association Minnesota-North Dakota in collaboration ... segment of The Alzheimer,s Project on May 12 at ... screening will be followed by a question-and-answer panel of ... for the disease, The Alzheimer,s Project shows there is ...
... Exforge HCT combines a proven calcium channel blocker, ... in one pill - In a clinical trial, ... and diastolic BP, compared to all dual combinations ... patients may need multiple medications to help control ...
Cached Medicine News:Health News:Solta Medical Receives Regulatory Approval to Market Thermage Systems in China 2Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 2Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 3Health News:Sumitomo to Act As Advisor to ProMetic for Japanese Market 4Health News:Cancer-causing virus associated with higher risk of new HIV infection 2Health News:Pennsylvania Pork Products Safe During H1N1 Flu Outbreak, Says Ag Secretary 2Health News:The Alzheimer's Project HBO Documentary Puts Spotlight On Alzheimer's Disease; Premiere Screening at the Hennepin County Library in Downtown Minneapolis 2Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 2Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 3Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 4Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 5Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 6Health News:Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill 7
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
(Date:1/15/2014)... , Jan. 15, 2014  In an unprecedented effort to curb the ... ambulances and other transport vehicles, an advanced and portable UV germicidal ... for the first time. In order to prevent ... deadly pathogens, West Palm Beach Fire Rescue ...
(Date:1/15/2014)... 2014  According to Millennium Research Group (MRG), the ... the United States and European ... expand moderately through 2022, with embolization particles representing ... interest in drug-eluting beads (DEBs) and radioembolization spheres ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
Iso-Electric Determination Kit; contains 1 bottle of 40 nm Naked Gold Iso-Electric Determination Kit to optimize gold conjugation of antibodies...
Colloidal Gold Conjugated, Goat anti-rabbit IgG (H&L) - 12 OD...
Colloidal Gold Conjugated, Goat anti-human IgM (Mu Chain) - 50 OD...
Colloidal Gold Conjugated, Rabbit anti-goat IgG (H&L) - 12 OD...
Medicine Products: