Navigation Links
Disorderly enzyme is key for antibody diversity
Date:6/27/2011

sequences comprising three bases found along the DNA.

Unlike most enzymes that are exquisitely efficient in targeting favored motifs, they found that AID was extremely inefficient. AID initiated chemical reactions in favored motifs only about 3 percent of the time. By mutating the motifs so haphazardly, the researchers suggest that AID produces antibody diversity.

The study also sheds light on a little-studied group of enzymes. Enzymes such as AID that scan single-stranded DNA have been studied far less extensively than enzymes that scan double-stranded DNA.

"This is the first really clear picture of what AID is doing during the scanning process," Goodman said.

To identify and describe AID's complex process during scanning, the team used a genetic assay to measure the distribution of AID-induced mutations on individual DNA molecules and then analyzed the mutational data computationally using a random walk model, developed for the study by USC Dornsife researcher Peter Calabrese. By combining the genetic and computational analyses, they were able to calculate the distribution of mutations that occurred with a remarkable fit to their experimental data. The fit entailed matching theory to experiment for the patterns of closely spaced mutations and separately for the distances between mutated and non-mutated target motifs.


'/>"/>

Contact: Michelle Salzman
msalzman@dornsife.usc.edu
213-821-9311
University of Southern California
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada
2. Enzyme may drive breast cancer growth
3. Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
4. The TET1 enzyme steers us through fetal development and fights cancer
5. Investigators discover enzyme essential for healthy lung development
6. Newly discovered role for enzyme in neurodegenerative diseases
7. Enzyme helps prepare lung tissue for metastatic development
8. Heart Enzymes May Predict Outcome After Bypass Surgery
9. Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
10. Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
11. Chaperone enzyme provides new target for cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... Raleigh, NC (PRWEB) April 18, 2015 ... the risk of developing mesothelioma later in life, but ... ways from mesothelioma that is unrelated to radiation. Surviving ... study on its website. Click here to read ... and Australia compared the cases of 45 patients who ...
(Date:4/18/2015)... than 2000 styles of newly designed prom dresses are ... carrying celebrity inspired special occasion dresses. With the prom ... for their prom. For those who are still looking ... be an ideal choice. , "We have by ... the most loved styles seen at this years major ...
(Date:4/18/2015)... April 18, 2015 “ ArcAngel ” was ... takes a look at the latest and coolest ... Troohey, the host of AppWatch and technology expert, conducted the ... personal safety app. , In a turbulent world, people ... Calling 911 should always be their first move, but some ...
(Date:4/17/2015)... Illinois (PRWEB) April 18, 2015 Heritage ... will begin its Supportive Living Week Celebration on April ... on having a healthy mind, body and soul. , ... in McLeansboro, Illinois, serves older adults of all incomes, ... maintain their independence. , Supportive Living Week is observed ...
(Date:4/17/2015)... 2015 ERGO-Pedic Products, LLC, which produces ... new products to help a broader range of people ... are the second most common visitors to doctors. , ... specifically to help relieve sitting pain. Then, only a ... of happy customers later, we began getting questions from ...
Breaking Medicine News(10 mins):Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Seat Cushion Company Credits Customer Driven Design For Two New Products 2
... , WICHITA, Kan., Aug. 10 Operation Rescue ... aimed at stopping abortionist LeRoy Carhart from opening an international late-term ... considered an urgent priority in a larger c a ... in any state. , , In order for Carhart ...
... Chairman ... , ... (PRWEB) August 10, 2009 -- This year,s National Association of Chain Drug Stores ... focused extensively on the healthcare reform debate. During the 52nd annual Conference, experts ...
... , , NEW YORK, Aug. 10 ... leading global information and media company and the CLIO Awards, one of the ... the online entry system, currently open at www.CLIOHealthcare.com for first-ever CLIO ... has been extended. For all work appearing between January 1, 2008 and June ...
... , PITTSBURGH, Aug. 10 ... of diagnostic imaging professional services and Vital Images (Nasdaq: ... analysis software, have partnered to bring Vital Images, advanced visualization ... full suite of software exclusively with its customer base of ...
... idiopathic chronic cholestatic inflammatory liver disease characterized by diffuse ... in bile duct obliteration, biliary cirrhosis, and eventually hepatic ... time of presentation of PSC is mild to severe ... the mechanisms responsible for the abdominal pain in PSC ...
... or ,borrowed, drugs, study found , MONDAY, Aug. 10 (HealthDay ... drugs such as antibiotics and allergy medications with friends, a ... new study. , For example, a teen who,s taking the ... defects -- may give some to a friend who is ...
Cached Medicine News:Health News:Urgent Petition Launched to Block Plans for New International Late-Term Abortion Clinic 2Health News:NACDS Pharmacy and Technology Conference Focuses on Reform 2Health News:NACDS Pharmacy and Technology Conference Focuses on Reform 3Health News:NACDS Pharmacy and Technology Conference Focuses on Reform 4Health News:Nielsen Announces Entry Deadline Extension for the First-Ever CLIO Healthcare Awards 2Health News:Foundation Radiology Group and Vital Images' Partnership Brings Advanced Visualization to Small Medical Communities Nationwide 2Health News:Gallbladder emptying in primary sclerosing cholangitis patients 2Health News:Sharing Prescription Meds Common Among U.S. Teens 2
(Date:4/16/2015)... China , April 16, 2015 ... leading developer, manufacturer, and marketer of medical devices ... the Securities and Exchange Commission an Annual Report on ... the year ended December 31, 2014. An electronic version ... available on Mindray,s investor relations website at  http://ir.mindray.com ...
(Date:4/16/2015)... OAKS, Calif. , April 16, 2015  Amgen ... report its first quarter financial results on Tuesday, April ... markets. The announcement will be followed by a conference ... Participating in the call from Amgen will be ... and other members of Amgen,s senior management team. ...
(Date:4/16/2015)... 16, 2015  Rosewind Corporation (OTCMKTS: RSWN) announced ... with a newly formed specialty healthcare company focused ... addressing urological disorders. The merged company, which is ... commenced operations and incorporates the pipeline assets of ... strategy is to build a late-stage and commercial ...
Breaking Medicine Technology:Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 2Rosewind Corporation Shifts Focus to Develop Late-Stage Therapeutics for Urological and Related Conditions 3
... Chicago-Area Community Hospital to Offer New Clinical Study to Breast ... ... 29 Little Company of Mary,Hospital and Health Care Centers in ... a new clinical study by Xoft using electronic brachytherapy for the,treatment ...
... Data Posted Online Shows Improvements Across Care Center,Network, ... Fibrosis,Foundation reported today that key indicators of health ... and nutritional status -- are,rising nationwide across its ... outlook for people with CF continues to improve ...
Cached Medicine Technology:Breast Cancer Treatment Is Reduced to One Week 2Cystic Fibrosis Foundation Reports Upward Trend for Key Health Outcomes 2
... a number of assay steps for ... simple to use benchtop device. The ... stand-alone device but also provides easy ... and standard add-on modules provide maximum ...
... The AVOXimeter 4000 provides a fast, ... bedside. The AVOXimeters patented,state-of-the-art optics yield ... as well as total hemoglobin. When,used ... analyzer, the AVOXimeter,4000 gives a comprehensive ...
The Stat Profile pHOx CO-Oximeter is intended for use in those situations where a more comprehensive profile beyond the measured hematocrit, hemoglobin, and SO2% offered by the Stat Profile pHOx ...
The IL 682 is the Gold Standard for CO-Oximetry analysis....
Medicine Products: