Navigation Links
Discovery to Facilitate Eradication of Polio Worldwide
Date:1/14/2014

Charlottesville, VA (PRWEB) January 14, 2014

Researchers at the University of Virginia School of Medicine and their collaborators have identified why oral vaccinations for polio and rotavirus are far less effective in the developing world than in the West. The culprits: malnutrition, diarrhea and abbreviated breastfeeding.

Polio vaccines given orally to children in the developing world are only about half as effective as in the United States. Until now, doctors were unsure why that was the case. The new research not only sheds light on the matter but points to simple strategies that could help overcome the problem, a major roadblock in the international effort to eradicate polio around the world.

Common Characteristics
The researchers followed children in an urban slum of Dhaka, Bangladesh, from birth to one year. Those children in which the vaccine proved ineffective tended to share certain characteristics.

“Children who had two or more episodes of diarrhea were twice as likely to fail polio vaccination. Malnourished children, and children who were weaned early from exclusive breastfeeding, were also more likely to have a poor response to vaccination,” explained William Petri Jr., MD, PhD, chief of UVA’s Division of Infectious Diseases and International Health. “While our observations need to be validated and extended at other regions of the developing world, they are encouraging to me as they suggest that very simple interventions, such as promoting exclusive breastfeeding, can improve vaccination and hasten eradication of polio.”

Critical Factors
The factors associated with oral vaccine ineffectiveness are common in developing countries, Petri noted. Up to 40 percent of children there are undernourished, diarrhea is a leading cause of death, and breastfeeding is often of shortened duration, he said. Notably, oral vaccines have a much higher failure rate than ones given by injection – suggesting another potential approach to surmounting the problem.

“It is remarkable to have the opportunity to discover the reasons why a vaccine that is one of the most commonly administered worldwide does not always work properly,” Petri said.

Published Online
The findings have been published online by the journal Vaccine and will appear in a forthcoming print edition. The article was authored by Rashidul Haque, of the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh; UVA’s Cynthia Snider, Yue Liu and Jennie Z. Ma; Lei Liu of Northwestern University; UVA’s Uma Nayak, Josyf C. Mychaleckyj and Poonum Korpe; Dinesh Mondal, Mamun Kabir and Masud Alam, of the International Centre; Mark Pallansch, M. Steven Oberste and William Weldon, of the Centers for Disease Control and Prevention; Beth D. Kirkpatrick, of the University of Vermont College of Medicine; and Petri.

Read the full story at http://www.prweb.com/releases/2014/01/prweb11487771.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Cell division discovery could offer fresh insight into cancer
2. Expert Project Manager Joins TERIS, a National Leader in eDiscovery, Information Governance, Computer Forensics and Relativity
3. Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order Pertaining to Discovery in Federal Boston Scientific Litigation
4. Judge Overseeing Federal Biomet Hip Lawsuits Won't Name Special Discovery Master, Bernstein Liebhard LLP Reports
5. Ovarian cancer discovery deepens knowledge of survival outcomes
6. Discovery of Partial Skeleton Suggests Ruggedly Built, Tree-climbing Human Ancestor
7. StyleSpotter Launches Powerful Fashion Discovery Experience for iPad
8. Macrocycles: Discovery and Development, Company Profiles, and Technologies
9. Discovery of brain activity in severely brain injured patients who wake up w/ sleep drug
10. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
11. New discovery on early immune system development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... Angeles, California (PRWEB) , ... February 13, 2016 , ... ... help landing a date for the big day. A great outfit, flawless hair, and ... ashtray, they might as well resign themselves to a night at home with Rover. ...
(Date:2/13/2016)... Viejo, CA (PRWEB) , ... February 13, 2016 , ... ... ember particle overlays to footage all within Final Cut Pro X. Each user can ... control over 3D rotation, angle of view, blur, focus offset, hue, saturation, value, contrast, ...
(Date:2/13/2016)... ... February 13, 2016 , ... Christie Medical ... in-kind gift of a VeinViewer® Vision vein finder for the nursing ... start an IV and draw blood, combining technology with traditional technique. , “VeinViewer ...
(Date:2/13/2016)... ... , ... DDi , a Makro company, makes it ... expertise in eClinical Solutions. DDi has built its solution competency with a unique ... clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains by ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & ... purpose of these scholarships is to encourage applicants to pursue a degree in their ... these two parishes. , “We have available jobs in St. Landry and Evangeline ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  Kindred Biosciences, Inc. (NASDAQ: KIN ), ... lives of pets, today announced the submission to FDA ... Drug Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  Positive ... Zimeta for the control of pyrexia (fever) in horses ... --> --> The Chemistry, Manufacturing, and ...
(Date:2/11/2016)... , Feb. 11, 2016   Health 2.0 ... of new health technologies, announced today " 10 Year ... in health tech over the past ten years.   ... nearly a decade, Health 2.0 has served as the ... and connected with thousands of technologies, companies, innovators, and ...
(Date:2/11/2016)... 11, 2016  MiMedx Group, Inc. (NASDAQ: MDXG ... membrane and other birth tissues, human skin and bone, ... market advanced products and therapies, announced today that it ... Healthcare Conference in New York , ... Michael J. Senken , Chief Financial Officer and ...
Breaking Medicine Technology: