Navigation Links
Discovery to Facilitate Eradication of Polio Worldwide

Charlottesville, VA (PRWEB) January 14, 2014

Researchers at the University of Virginia School of Medicine and their collaborators have identified why oral vaccinations for polio and rotavirus are far less effective in the developing world than in the West. The culprits: malnutrition, diarrhea and abbreviated breastfeeding.

Polio vaccines given orally to children in the developing world are only about half as effective as in the United States. Until now, doctors were unsure why that was the case. The new research not only sheds light on the matter but points to simple strategies that could help overcome the problem, a major roadblock in the international effort to eradicate polio around the world.

Common Characteristics
The researchers followed children in an urban slum of Dhaka, Bangladesh, from birth to one year. Those children in which the vaccine proved ineffective tended to share certain characteristics.

“Children who had two or more episodes of diarrhea were twice as likely to fail polio vaccination. Malnourished children, and children who were weaned early from exclusive breastfeeding, were also more likely to have a poor response to vaccination,” explained William Petri Jr., MD, PhD, chief of UVA’s Division of Infectious Diseases and International Health. “While our observations need to be validated and extended at other regions of the developing world, they are encouraging to me as they suggest that very simple interventions, such as promoting exclusive breastfeeding, can improve vaccination and hasten eradication of polio.”

Critical Factors
The factors associated with oral vaccine ineffectiveness are common in developing countries, Petri noted. Up to 40 percent of children there are undernourished, diarrhea is a leading cause of death, and breastfeeding is often of shortened duration, he said. Notably, oral vaccines have a much higher failure rate than ones given by injection – suggesting another potential approach to surmounting the problem.

“It is remarkable to have the opportunity to discover the reasons why a vaccine that is one of the most commonly administered worldwide does not always work properly,” Petri said.

Published Online
The findings have been published online by the journal Vaccine and will appear in a forthcoming print edition. The article was authored by Rashidul Haque, of the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh; UVA’s Cynthia Snider, Yue Liu and Jennie Z. Ma; Lei Liu of Northwestern University; UVA’s Uma Nayak, Josyf C. Mychaleckyj and Poonum Korpe; Dinesh Mondal, Mamun Kabir and Masud Alam, of the International Centre; Mark Pallansch, M. Steven Oberste and William Weldon, of the Centers for Disease Control and Prevention; Beth D. Kirkpatrick, of the University of Vermont College of Medicine; and Petri.

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Cell division discovery could offer fresh insight into cancer
2. Expert Project Manager Joins TERIS, a National Leader in eDiscovery, Information Governance, Computer Forensics and Relativity
3. Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order Pertaining to Discovery in Federal Boston Scientific Litigation
4. Judge Overseeing Federal Biomet Hip Lawsuits Won't Name Special Discovery Master, Bernstein Liebhard LLP Reports
5. Ovarian cancer discovery deepens knowledge of survival outcomes
6. Discovery of Partial Skeleton Suggests Ruggedly Built, Tree-climbing Human Ancestor
7. StyleSpotter Launches Powerful Fashion Discovery Experience for iPad
8. Macrocycles: Discovery and Development, Company Profiles, and Technologies
9. Discovery of brain activity in severely brain injured patients who wake up w/ sleep drug
10. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
11. New discovery on early immune system development
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, the leading ... with Tennessee Counseling Association. This new relationship allows TherapySites to continue ... Association, adding exclusive benefits and promotional offers. , "TCA is extremely excited about ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: