Navigation Links
Discovery suggests new combination therapy strategy for basal-like breast cancers
Date:5/21/2012

CHAPEL HILL, N.C. Multiple research projects including a 2006 study conducted at the University of North Carolina at Chapel Hill have used DNA microarray analysis to identify several breast cancer subtypes, including luminal A, luminal B, basal-like and HER2-enriched. Simple tests are being developed to help doctors identify these subtypes and to treat their patients in a more biologically-based way. In turn, these tests have made several studies possible that indicate that basal-like, or triple negative breast cancer, is more prevalent in African Americans than their Caucasian counterparts.

A new study led by UNC Lineberger scientist Charles Perou, PhD, and Sean Egan, PhD, from The Hospital for Sick Children in Toronto, Ontario, demonstrates that deletion of a sugar transferase called LFNG (nicknamed "lunatic fringe"), promotes cell proliferation and tumor formation of basal-like breast cancers. The study was published last week in the journal Cancer Cell.

In a laboratory model, the deletion of LFNG not only caused tumors to form but also activated two cellular signaling pathways thought to be important in tumor formation. The team found increased activation of both notch signaling (a receptor found on the surface of cells that is involved in stem cell differentiation and development) and increased expression of the Met oncogene.

Taking the laboratory model a step further, the team examined these same genes and signaling pathways in basal-like tumors and found the same genetic signature.

"This is exciting because there are drugs in development that target each of these pathways. While targeting each pathway alone might work, our findings suggest that combination therapy could be a promising strategy for treating these basal-like tumors," says Dr. Perou, who is the May Goldman Shaw Distinguished Professor of Molecular Oncology and professor of genetics, and pathology and laboratory medicine at the UNC School of
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers make promising discovery in pursuit of effective lymphoma treatments
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. H1N1 discovery paves way for universal flu vaccine: UBC research
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. Discovery could help to develop drugs for organ transplant and cancer patients
6. Washingtons Life Sciences Discovery Fund awards commercialization grants
7. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
8. New discovery of proteins involved in positioning muscular nuclei
9. Cell signaling discovery provides new hope for blood disorders
10. Gene mutation discovery sparks hope for effective endometriosis screening
11. Discovery predicts patient sensitivity to important drug target in deadly brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Thompson HealthDay Reporter WEDNESDAY, ... mugged in a dark alley will likely never want to ... being attacked. But neuroscientists working with mice say they,ve ... with positive and negative emotions. And in rodent tests, they,ve ... memory. In essence, they made once-reluctant mice want to ...
(Date:8/27/2014)... Young adults who struggled with depression in adolescence appear ... reporting. The findings might improve understanding of depression ... and treat the illness, according to the University of ... scans on 30 volunteers, ages 18 to 23, who ... group of 23 young adults who never had depression. ...
(Date:8/27/2014)... Bottom Line: Photodynamic therapy (PDT, which uses topical agents ... actinic keratoses (AKs, a common skin lesion caused by ... (which uses liquid nitrogen to freeze lesions). ... of California Davis Medical Center, in Sacramento, and colleagues. ... on the skin typically found on individuals with fair ...
(Date:8/27/2014)... 27, 2014 Ticket Down is ... at Levi’s Stadium in Santa Clara. Levi’s Stadium ... California just opened in July and will host their first ... on Chile. These are two of the best teams that ... Cup and will look to continue their successes from the ...
(Date:8/27/2014)... 2014 BRIC Laparoscopes Market Outlook to ... key market data on the BRIC Laparoscopes market. The ... (in units) and average prices (in US dollars) within ... Flexible Tip Video Laparoscopes), Robotic Surgical Systems and Rigid ... advantages to the patient with laparoscopic surgery versus the ...
Breaking Medicine News(10 mins):Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Study: Young Adults Who Had Depression Have 'Hyper-Connected' Brain Networks 2Health News:Photodynamic therapy vs. cryotherapy for actinic keratoses 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 2Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 4
... tribal children have died of pneumonia in Orissa's Mayurbhanj district ... from the illness// , officials said Sunday. ,The children, ... village located 150 km from the district head quarter of ... the local government hospital at Jashipur by a medical team ...
... high-end laboratory and diagnostic testing! Indian labs offer a comprehensive ... , A number of hospitals in the US ... as it costs about 70 to 80 per cent less ... limited to highly-specialised tests but experts say outsourcing of laboratory ...
... Kolkata as here the disease has been contained said Dr ... Programme. // ,Speaking at an all-India seminar ... only person died of Malaria whereas in Bombay the number ... Bihar, Jharkhand Orissa, Assam and Pondichery participated in the seminar. ...
... YES Bank has signed an MoU with a leading the ... dollar health care fund catering to the Indian market within ... house will run the fund, for which YES Bank would ... foray for the fund-house, which is currently Europe-centric., ,"The ...
... first eventually Neemuch, a town in Madhya Pradesh, soon grew to ... 3,000 people in India have had their vision restored to them ... from Neemuch had pledged his eyes before he died because of ... the town has the highest per capita eye donation rate in ...
... According to a new study in Britain it is found ... // ,Hence the new 2006 Pregnancy Book comes ... information and prepares both the mother and father on the ... sickness. The book is published by the experts from the ...
Cached Medicine News:
(Date:8/27/2014)... VANCOUVER, British Columbia and MENLO ... DelMar Pharmaceuticals, Inc. , (OTCQB: DMPI), developer of ... presenting company at the 16th Annual Rodman & Renshaw ... & Co., LLC. The presentation will take place Tuesday, September ... Salon (4th floor) at the New York Palace Hotel ...
(Date:8/27/2014)... About 8 million Americans have peripheral arterial ... fatty plaque in the arteries, according to recent statistics. ... in incidences of diabetes and obesity, the Society ... Arterial RevascularizatioN (LEARN) meeting, Oct. 9–11 in ... residents and fellows will be able to gain state-of-the-art ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... "Global Pulse Oximeter Industry Report 2014" report ... Oximeter Industry Report 2014 is a professional and in-depth ... oximeter industry. The report provides a basic ... industry chain structure. The pulse oximeter market analysis is ...
Breaking Medicine Technology:DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 2DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 3DelMar Pharmaceuticals To Present At The 16th Annual Rodman & Renshaw Global Investment Conference 4LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3Global Pulse Oximeter Industry Report 2014 2
Cold light source single outlet....
Cold light source single outlet....
Cold light source triple outlet....
Cold light source triple outlet....
Medicine Products: