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Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
Date:8/31/2007

the signal was just as strong. That means the location that we have identified on chromosome 5p does not appear to affect breast density through its influence on BMI, she said.

Only age, diagnosis of abnormal cells on a breast biopsy and inheritance of rare breast susceptibility genes, such as BRCA1 and BRCA2, are stronger risk predictors of breast cancer than is breast density, Vachon said.

At this point, we have not identified a gene or genes for breast density but a promising location to investigate further, Vachon said. Identification of genes for breast density will improve our understanding of how breast density influences breast cancer development in women.

In this study we focused on the genetics of a risk factor for cancer. This approach has not been tried before, said Thomas Sellers, Ph.D., a coauthor on this study and currently director of the Moffitt Research Institute in Tampa, Florida.


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Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

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